My main research interest is in the epidemiology of inflammatory musculoskeletal conditions – in particular, risk factors for the development and outcome of rheumatoid arthritis. I am a Principal Investigator for the Norfolk Arthritis Register and the BSR Biologics Register. I have a major interest in drug safety and pharmacoepidemiology. I was the Director of the NIHR Manchester Musculoskeletal BRU until April 2014, and remain the Lead for the Prevention of Co-Morbidity Research theme. I was the Director of the Arthritis Research UK Centre for Epidemiology until August 2014 and remain involved in the Norfolk Arthritis Register and BSR Biologics Register-RA programmes.