Prof David Thornton BSc, PhD

Professor of Biochemistry

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Publications

  1. 2020
  2. Published

    Trickle infection and immunity to Trichuris muris

    Glover, M., Colombo, S., Thornton, D. & Grencis, R., 2020, In: PL o S Pathogens. 15, 11, p. 1-27 27 p., e1007926.

    Research output: Contribution to journalArticlepeer-review

  3. 2019
  4. Published

    The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function

    Bancroft, A., Levy, C., Jowitt, T., Hayes, K., Thompson, S., Mckenzie, E., Ball, M., Dubaissi, E., France, A., Bellina, B., Sharpe, C., Mironov, A., Brown, S., Cook, P., MacDonald, A., Thornton, D. & Grencis, R., 28 May 2019, In: Nature Communications. 10, 1, p. 0 2344.

    Research output: Contribution to journalArticlepeer-review

  5. Published

    A novel glycopolymer improves abnormal cystic fibrosis mucus

    Fernanadez-Petty, C. M., Hughes, G., Bowers, H. L., Watson, J. D., Rosen, B. H., Townsend, S. M., Santos, C., Ridley, C., Chu, K. K., Birket, S. E., Li, Y., Leung, H. M., Mazur, M., Garcia, B. A., Apak Evans, T. I., Falk Libby, E., Hathorne, H., Hanes, J., Tearney, G. J., Clancy, J. P. & 6 others, Engelhardt, J. F., Swords, W. E., Thornton, D., Wiesmann, W. P., Baker, S. M. & Rowe, S. M., 18 Apr 2019, In: Journal of Clinical Investigation Insight. 4, 8, e125954.

    Research output: Contribution to journalArticlepeer-review

  6. Published

    The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

    Svedberg, F. R., Brown, S. L., Krauss, M. Z., Campbell, L., Sharpe, C., Clausen, M., Howell, G. J., Clark, H., Madsen, J., Evans, C. M., Sutherland, T. E., Ivens, A. C., Thornton, D. J., Grencis, R. K., Hussell, T., Cunoosamy, D. M., Cook, P. C. & MacDonald, A. S., 1 Apr 2019, In: Nature Immunology. 20, 5, p. 571-580 10 p.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites

    Campbell, L., Hepworth, M., Whittingham-Dowd, J., Thompson, S., Bancroft, A., Hayes, K., Shaw, T., Dickey, B. F., Flammar, A-L., Artis, D., Schwartz, D. A., Evans, C. M., Roberts, I., Thornton, D. & Grencis, R., 2019, In: Journal of Experimental Medicine. 216, 12, p. 2714–2723

    Research output: Contribution to journalArticlepeer-review

  8. Published

    The C-terminal dimerization domain of the respiratory mucin MUC5B functions in mucin stability and intracellular packaging before secretion

    Ridley, C., Lockhart-cairns, M. P., Collins, R. F., Jowitt, T. A., Subramani, D. B., Kesimer, M., Baldock, C. & Thornton, D. J., 2019, In: Journal of Biological Chemistry. p. jbc.RA119.010771

    Research output: Contribution to journalArticlepeer-review

  9. Published

    The MUC5B mucin polymer is dominated by repeating structural motifs and its topology is regulated by calcium and pH

    Hughes, G., Ridley, C., Collins, R., Roseman, A., Ford, R. & Thornton, D., 2019, In: Scientific Reports. 9, p. 1-13 13 p., 17350.

    Research output: Contribution to journalArticlepeer-review

  10. 2018
  11. Published

    Dropping acid: why is cystic fibrosis mucus abnormal?

    Rubin, B. K. & Thornton, D. J., Dec 2018, In: European Respiratory Journal. 52, 6, 1802057.

    Research output: Contribution to journalEditorialpeer-review

  12. Published

    Mucins: the frontline defence of the lung

    Ridley, C. & Thornton, D., Oct 2018, In: Biochemical Society Transactions. 46, 5, p. 1099-1106

    Research output: Contribution to journalArticlepeer-review

  13. Published

    Extracellular vesicles induce protective immunity against Trichuris muris

    Shears, R., Bancroft, A., Hughes, G., Grencis, R. & Thornton, D., 27 Jun 2018, In: Parasite Immunology. 40, 7

    Research output: Contribution to journalArticlepeer-review

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