Dr David Talavera
Lecturer in Genetics/Genomics
Research interests
My main research interest is in understanding why some variation (either quantitative or qualitative) is tolerated whereas other variation is deleterious.
Identification and interpretation of genetic variants linked to cardiovascular diseases
Cardiovascular diseases encompass many diverse conditions with very dissimilar origins; e.g., congenital, environmental, or as a complication of diseases such as kidney failure or diabetes mellitus. Therefore the comprehension of the pathophysiology of diseases not only relies on the identification of the genetic causes and the influence of external factors, but also on the understanding of the molecular consequences caused by any anomaly. This highlights the necessity for approaches that permit modelling the systemic changes (from transcriptional variation to protein degradation) undergoing within the cell.
Transcriptional and translational response to stress
Yeast is a very useful model organism for studying basic global processes such as translational control and stress response. We have been collaborating extensively with the Pavitt, Grant, O'Keefe, Ashe, and Hubbard labs in the study of some of these processes.
Projects
Research and projects
No current projects are available for public display