Prof David Leys PhD

Professor of Structural Biology

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Publications

  1. 2020
  2. E-pub ahead of print

    Heterologous expression of cobalamin dependent class-III enzymes

    Halliwell, T., Fisher, K., Payne, K., Rigby, S. E. J. & Leys, D., 29 Aug 2020, In : Protein Expression and Purification. p. 105743

    Research output: Contribution to journalArticle

  3. Accepted/In press

    Catabolic reductive dehalogenase substrate complex structures underpin rational repurposing of substrate scope

    Halliwell, T., Fisher, K., Payne, K., Rigby, S. & Leys, D., 28 Aug 2020, (Accepted/In press) In : Microorganisms.

    Research output: Contribution to journalArticle

  4. Accepted/In press

    Ferulic acid decarboxylase (Fdc1) controls oxidative maturation of the prFMN cofactor

    Balaikaite, A., Chisanga, M., Fisher, K., Heyes, D., Spiess, R. & Leys, D., 25 Aug 2020, (Accepted/In press) In : ACS chemical biology.

    Research output: Contribution to journalArticle

  5. Accepted/In press

    Biocatalytic reduction of α,β-unsaturated carboxylic acids to allylic alcohols

    Aleku, G., Roberts, G. & Leys, D., 24 Apr 2020, (Accepted/In press) In : Green Chemistry.

    Research output: Contribution to journalArticle

  6. Published

    Flavin doesn’t put all oxygens in one basket

    Leys, D. & Scrutton, N. S., 22 Apr 2020, In : Nature chemical biology. 16, 5, p. 485-486

    Research output: Contribution to journalArticle

  7. 2019
  8. Published

    The UbiX flavin prenyltransferase reaction mechanism resembles Class I terpene cyclase chemistry

    Marshall, S., Payne, K., Fisher, K., White, M., Ni Cheallaigh, A., Balaikaite, A., Rigby, S. & Leys, D., 29 May 2019, In : Nature Communications.

    Research output: Contribution to journalArticle

  9. Published

    A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

    Zhang, S., Sakuma, M., Deora, G. S., Levy, C., Klausing, A., Breda, C., Read, K. D., Ross, B. P., Wright Muelas, M., Day, P., O'Hagan, S., Kell, D., Schwarcz, R., Leys, D., Heyes, D., Giorgini, F. & Scrutton, N., 2019, In : Communications Biology.

    Research output: Contribution to journalArticle

  10. Published

    Enzymatic Carboxylation of 2-Furoic Acid Yields 2,5-Furandicarboxylic Acid (FDCA)

    Payne, K. A. P., Marshall, S., Fisher, K., Cliff, M. J., Cannas, D., Yan, C., Heyes, D. J., Parker, D., Larrosa, I. & Leys, D., 2019, In : ACS Catalysis.

    Research output: Contribution to journalArticle

  11. Published

    Enzymatic control of cycloadduct conformation ensures reversible 1,3 dipolar cycloaddition in a prFMN dependent decarboxylase

    Bailey, S., Payne, K., Saaret, A., Marshall, S., Gostimskaya, I., Kosov, I., Fisher, K., Hay, S. & Leys, D., 2019, In : Nature Chemistry.

    Research output: Contribution to journalArticle

  12. Published

    Heterologous production, reconstitution and EPR spectroscopic analysis of prFMN dependent enzymes

    Marshall, S. A., Payne, K. A. P., Fisher, K., Gahloth, D., Bailey, S. S., Balaikaite, A., Saaret, A., Gostimskaya, I., Aleku, G., Huang, H., Rigby, S. E. J., Procter, D. & Leys, D., 2019, Methods in Enzymology. Vol. 620. p. 489-508 20 p. (Methods in Enzymology).

    Research output: Chapter in Book/Report/Conference proceedingChapter

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