Dr David Hallifax PhD CBiol CChem FRSB MRSC

(Former)

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ORCID: 0000-0002-3848-689X
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Publications

1 - 10 out of 53Page size: 10
  1. 2020
  2. Accepted/In press

    Impact of plasma protein binding in drug clearance prediction: a database analysis of published studies and implications for in vitro in vivo extrapolation

    Francis, L., Houston, J. & Hallifax, D., 5 Dec 2020, (Accepted/In press) In: Drug Metabolism and Disposition.

    Research output: Contribution to journal › Article › peer-review

  3. Published

    Utilising magnetically isolated lysosomes for direct quantification of intralysosomal drug concentrations by LC MS/MS analysis: An investigatory study with imipramine

    Francis, L., Harrell, A., Hallifax, D. & Galetin, A., 1 Sep 2020, In: Journal of Pharmaceutical Sciences. 109, 9, p. 2891-2901

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.xphs.2020.05.026
  4. 2019
  5. Published

    Use of segregated hepatocyte scaling factors and cross-species relationships to resolve clearance dependence in the prediction of human hepatic clearance

    Hallifax, D. & Houston, J., 1 Mar 2019, In: Drug Metabolism and Disposition -Bethesda-. 47, 3, p. 320-327 8 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1124/dmd.118.085191
  6. 2018
  7. Published

    Importance of the unstirred water layer and hepatocyte membrane integrity in vitro for quantification of intrinsic metabolic clearance

    Wood, F., Houston, J. & Hallifax, D., 1 Jan 2018, In: Drug Metabolism and Disposition. 46, 1

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1124/dmd.117.078949
  8. Published

    The impact of lysosomal sequestration on desipramine cellular disposition and metabolic drug-drug interactions in rat and human hepatocytes

    Ufuk, A., Matsunaga, N., Hallifax, D. & Galetin, A., Jan 2018, In: Drug Metabolism and Pharmacokinetics.

    Research output: Contribution to journal › Article

    DOI: 10.1016/j.dmpk.2017.11.162
  9. 2017
  10. Published

    Clearance prediction methodology needs fundamental improvement: Trends common to rat and human hepatocytes/microsomes and implications for experimental methodology

    Wood, F. L., Houston, J. B. & Hallifax, D., 1 Nov 2017, In: Drug Metabolism and Disposition. 45, 11, p. 1178-1188 11 p.

    Research output: Contribution to journal › Comment/debate › peer-review

    DOI: 10.1124/dmd.117.077040
  11. Published

    Novel Methodology for the Isolation of Lysosomes and Measurement of Intralysosomal Drug Accumulation

    Francis, L., Ufuk, A., Harrell, A., Hallifax, D. & Galetin, A., 2017.

    Research output: Contribution to conference › Poster

  12. Published

    Revisiting human tissue drug distribution: Limitations of current prediction models and potential impact of lipid contributions in fraction unbound

    Musther, H., Ghosh, A., Gardner, I., Rostami-Hodjegan, A. & Hallifax, D., 2017.

    Research output: Contribution to conference › Poster

  13. 2015
  14. Published

    Assessing metabolic competence in isolated hepatocytes: Exploring the relationship between enzyme function and plasma membrane integrity via Saponin treatment

    Wood, F., Hallifax, D. & Houston, B., Jun 2015, host publication. Vol. P10.

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  15. Published

    Characterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins

    Rowland, A., Hallifax, D., Nussio, M., Shapter, J., Mackenzie, P., Houston, J. B., Knights, K. M. & Miners, J. O., 24 Mar 2015, In: Xenobiotica. 45, 10, p. 847-857 10 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.3109/00498254.2015.1021403
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Research Explorer downloads

78
Use of segregated hepatocyte scaling factors and cross-species relationships to resolve clearance dependence in the prediction of human hepatic clearance

Research output: Contribution to journal › Article › peer-review

11
Utilising magnetically isolated lysosomes for direct quantification of intralysosomal drug concentrations by LC MS/MS analysis: An investigatory study with imipramine

Research output: Contribution to journal › Article › peer-review