Dr Christine Schmidt

BBSRC David Phillips Fellow and Dean's Prize Early Career Researcher

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Postdoctoral researchers

María José Cabello (since August 2017)

mariajose.cabellolobato@manchester.ac.uk

María José received her PhD in 2016 at the Andalusian Centre of Molecular Biology and Regenerative Biomedice (Seville, Spain). She joined Christine’s lab in August 2017 as a postdoctoral researcher to work on the role of ubiquitin/SUMO modifications in the DNA damage response.

 

Elsa Irving (since February 2019)

elsa.irving1@astrazeneca.com

Elsa received her PhD from the UCL Great Ormond Street Institute of Child Health in 2019. She is now a postdoctoral fellow in collaboration with Josep Forment at AstraZeneca based in the DNA damage response group within oncology. She is working on targeting ubiquitylation factors in tumour cells, in particular in those with homologous repair deficiencies.

 

PhD students

Siyue Wang (since September 2017)

siyue.wang-2@postgrad.manchester.ac.uk

Siyue Wang obtained her Master’s degree in Applied Biomolecular Technology in 2013 from the University of Nottingham. From 2015 to 2017, she worked in Prof. Stephen Jackson’s lab at the Wellcome Trust/CRUK Gurdon Institute as a Senior Research Technician. She joined Christine’s lab in September 2017 as a PhD student to work on the function of ubiquitylation in the DNA damage response.

 

Hugh Osborne (since October 2018)

Hugh.Osborne@postgrad.manchester.ac.uk

Hugh Osborne obtained a Master’s degree in Pharmacy (MPharm) in 2016 from the University of East Anglia (UEA), with a focus on medicinal chemistry. He went on to complete his pre-registration year at the Norfolk & Norwich University Hospital, qualifying as a pharmacist in August 2017. He then worked as a locum pharmacist and as a Blue Book Trainee for the European Commission (Grange, Ireland) before joining Christine’s and Igor Larrosa's labs in September 2018 as a PhD student to work on the development of ubiquitylation inhibitors in the context of the DNA damage response and certain cancer types.

 

Isabelle Cristine Da Costa (since October 2018)

isabellecristine.dacosta@postgrad.manchester.ac.uk

Isabelle Cristine has a conjoined BSc in Biotechnology from the Federal University of Goias (Brazil) and Michigan State University (USA) and an industrial internship on lung cancer at Abbot/AbbVie Laboratories (USA). She obtained her Master's degree in Biological Sciences in 2018 from the University of Manchester where she worked with haematopoietic stem cells (Dr Valerie Kouskoff's lab) and creation of yeast hybrids with biotechnological applications (Prof. Daniela Delneri's lab). Her current research in Dr Schmidt's lab focuses on understanding the function and molecular pathways of ubiquitylation factors in the DNA damage response and how those factors are related to the prostate cancer setting. 

 

Konstancja Urbaniak (since September 2018)

konstancja.urbaniak@postgrad.manchester.ac.uk

Konstancja Urbaniak obtained her Master’s by Research (MRes) in Molecular and Cellular Medicine in 2017 from the University of Bristol where she worked on the correlation between posttranslational modifications and dynamics of microtubules and DNA damage response signalling. In September 2018, she started an A*STAR PhD programme in Dr Christine Schmidt’s, Dr Jim Warwicker’s and Dr Frank Eisenhaber’s labs. Her research is focused on the systematic identification of ubiquitin binding proteins in relation to the DNA damage response.

 

Zac Sandy (since October 2019)

zac.sandy@postgrad.manchester.ac.uk

Zac Sandy obtained his Master’s degree (MRes) in Cancer Science in 2019 from the University of Birmingham. There he worked in Dr Clare Davies’ lab investigating the roles of arginine modifications in the DNA damage response. In October 2019 he joined Christine’s lab as part of a BBSRC CTP studentship in collaboration with Dr Josep Forment’s group at AstraZeneca. His current research focuses on exploring the roles of ubiquitin-like modifiers in the DNA damage response. 

 

Melanie Seaton (since October 2019)

melanie.seaton@postgrad.manchester.ac.uk

Melanie Seaton obtained an integrated Master’s degree in Pharmacology from The University of Manchester in 2019. For her final year project she worked in Prof. Stuart Allan’s lab on the mechanisms of inflammation in vascular dementia. She joined Christine’s lab in 2019 as a PhD student to work on the development of cellular micromotors for improved management of ovarian cancer.

 

Alumni

Stephenie Purvis (October 2018 - July 2019)

Stephenie gained her Bachelor's degree in Biomedical Science from the University of Kent in 2018. She joined the Genome Stability Lab for her research project as part of her MRes Oncology Master's degree. Since leaving, she has been accepted onto the highly competitive NHS Scientific Training Programme in Cambridge where she will not only be specialising in Cancer Genomics but also gaining another Master's degree in Clinicial Science.

 

Mariam Nasr (September 2017 - May 2018)

Mariam joined the Genome Stability Lab and Richard Edmondson's group as an undergraduate student in her final year of her MSci Genetics degree, looking into defects in homologous recombination in ovarian cancer cells.

Collaborators and affiliated staff

Ongoing external collaborations

  • Dr Petra Beli (Institute of Molecular Biology, Mainz, Germany)
  • Prof. Stephen P. Jackson (The Gurdon Institute, University of Cambridge, UK)
  • Prof. Oliver G. Schmidt and Dr Mariana Medina Sanchez (Institute for Integrative Nanosciences, IFW, Dresden, Germany)