Prof Catharine WestPhD

Professor of Radiation Biology

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Phone: +44 (0) 161 446 8275
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ORCID: 0000-0002-0839-3449
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Publications

1 - 10 out of 193Page size: 10
  1. 2019
  2. Published

    Dynamics of circulating vascular endothelial growth factor-A predict benefit from antiangiogenic cediranib in metastatic or recurrent cervical cancer patients.

    Zhou, C., Taylor, S., Tugwood, J., Simpson, K., Jayson, G., Symonds, P., Paul, J., Davidson, S., Carty, K., McCartney, E., Rai, D., Dive, C. & West, C., 1 Aug 2019, In : British Journal of Clinical Pharmacology.

    Research output: Contribution to journal › Article

    DOI: 10.1111/bcp.13965
  3. Published

    Radiogenomic predictors of adverse effects following charged particle therapy

    Morton, L. M., Ricks-Santi, L., West, C. M. L. & Rosenstein, B. S., 1 Jun 2019, In : International Journal of Particle Therapy. 5, 1, p. 103-113 11 p.

    Research output: Contribution to journal › Article

    DOI: 10.14338/IJPT-18-00009.1
  4. Published

    RAPPER — A Success Story for Collaborative Translational Radiotherapy Research

    Burnet, N. G., Barnett, G. C., Summersgill, H. R., Dunning, A. M. & West, C. M. L., 15 May 2019, In : Clinical Oncology.

    Research output: Contribution to journal › Editorial

    DOI: 10.1016/j.clon.2019.04.013
  5. E-pub ahead of print

    Association analyses identify 31 new risk loci for colorectal cancer susceptibility

    The PRACTICAL Consortium, 14 May 2019, In : Nature Communications. 10, 1, 2154.

    Research output: Contribution to journal › Article

    DOI: 10.1038/s41467-019-09775-w
  6. Published

    Radiogenomics in the Era of Advanced Radiotherapy

    Brothwell, M. R. S., West, C. M., Dunning, A. M., Burnet, N. G. & Barnett, G. C., 1 May 2019, In : Clinical Oncology. 31, 5, p. 319-325 7 p.

    Research output: Contribution to journal › Article

    DOI: 10.1016/j.clon.2019.02.006
  7. Accepted/In press

    Radiogenomics Consortium Genome-Wide Association Study Meta-analysis of Late Toxicity after Prostate Cancer Radiotherapy

    Radiogenomics Consortium, Elliott, R., Burnet, N., West, C. & et al., 29 Apr 2019, (Accepted/In press) In : Journal National Cancer Institute.

    Research output: Contribution to journal › Article

  8. Published

    Shared heritability and functional enrichment across six solid cancers

    Jiang, X., Finucane, H. K., Schumacher, F. R., Schmit, S. L., Tyrer, J. P., Han, Y., Michailidou, K., Lesseur, C., Kuchenbaecker, K. B., Dennis, J., Conti, D. V., Casey, G., Gaudet, M. M., Huyghe, J. R., Albanes, D., Aldrich, M. C., Andrew, A. S., Andrulis, I. L., Anton-Culver, H., Antoniou, A. C. & 313 othersAntonenkova, N. N., Arnold, S. M., Aronson, K. J., Arun, B. K., Bandera, E. V., Barkardottir, R. B., Barnes, D. R., Batra, J., Beckmann, M. W., Benitez, J., Benlloch, S., Berchuck, A., Berndt, S. I., Bickeböller, H., Bien, S. A., Blomqvist, C., Boccia, S., Bogdanova, N. V., Bojesen, S. E., Bolla, M. K., Brauch, H., Brenner, H., Brenton, J. D., Brook, M. N., Brunet, J., Brunnström, H., Buchanan, D. D., Burwinkel, B., Butzow, R., Cadoni, G., Caldés, T., Caligo, M. A., Campbell, I., Campbell, P. T., Cancel-Tassin, G., Cannon-Albright, L., Campa, D., Caporaso, N., Carvalho, A. L., Chan, A. T., Chang-Claude, J., Chanock, S. J., Chen, C., Christiani, D. C., Claes, K. B. M., Claessens, F., Clements, J., Collée, J. M., Correa, M. C., Couch, F. J., Cox, A., Cunningham, J. M., Cybulski, C., Czene, K., Daly, M. B., deFazio, A., Devilee, P., Diez, O., Gago-Dominguez, M., Donovan, J. L., Dörk, T., Duell, E. J., Dunning, A. M., Dwek, M., Eccles, D. M., Edlund, C. K., Edwards, D. R. V., Ellberg, C., Evans, D. G., Fasching, P. A., Ferris, R. L., Liloglou, T., Figueiredo, J. C., Fletcher, O., Fortner, R. T., Fostira, F., Franceschi, S., Friedman, E., Gallinger, S. J., Ganz, P. A., Garber, J., García-Sáenz, J. A., Gayther, S. A., Giles, G. G., Godwin, A. K., Goldberg, M. S., Goldgar, D. E., Goode, E. L., Goodman, M. T., Goodman, G., Grankvist, K., Greene, M. H., Gronberg, H., Gronwald, J., Guénel, P., Håkansson, N., Hall, P., Hamann, U., Hamdy, F. C., Hamilton, R. J., Hampe, J., Haugen, A., Heitz, F., Herrero, R., Hillemanns, P., Hoffmeister, M., Høgdall, E., Hong, Y-C., Hopper, J. L., Houlston, R., Hulick, P. J., Hunter, D. J., Huntsman, D. G., Idos, G., Imyanitov, E. N., Ingles, S. A., Isaacs, C., Jakubowska, A., James, P., Jenkins, M. A., Johansson, M., Johansson, M., John, E. M., Joshi, A. D., Kaneva, R., Karlan, B. Y., Kelemen, L. E., Kühl, T., Khaw, K-T., Khusnutdinova, E., Kibel, A. S., Kiemeney, L. A., Kim, J., Kjaer, S. K., Knight, J. A., Kogevinas, M., Kote-Jarai, Z., Koutros, S., Kristensen, V. N., Kupryjanczyk, J., Lacko, M., Lam, S., Lambrechts, D., Landi, M. T., Lazarus, P., Le, N. D., Lee, E., Lejbkowicz, F., Lenz, H-J., Leslie, G., Lessel, D., Lester, J., Levine, D. A., Li, L., Li, C. I., Lindblom, A., Lindor, N. M., Liu, G., Loupakis, F., Lubiński, J., Maehle, L., Maier, C., Mannermaa, A., Marchand, L. L., Margolin, S., May, T., McGuffog, L., Meindl, A., Middha, P., Miller, A., Milne, R. L., MacInnis, R. J., Modugno, F., Montagna, M., Moreno, V., Moysich, K. B., Mucci, L., Muir, K., Mulligan, A. M., Nathanson, K. L., Neal, D. E., Ness, A. R., Neuhausen, S. L., Nevanlinna, H., Newcomb, P. A., Newcomb, L. F., Nielsen, F. C., Nikitina-Zake, L., Nordestgaard, B. G., Nussbaum, R. L., Offit, K., Olah, E., Olama, A. A. A., Olopade, O. I., Olshan, A. F., Olsson, H., Osorio, A., Pandha, H., Park, J. Y., Pashayan, N., Parsons, M. T., Pejovic, T., Penney, K. L., Peters, W. H. M., Phelan, C. M., Phipps, A. I., Plaseska-Karanfilska, D., Pring, M., Prokofyeva, D., Radice, P., Stefansson, K., Ramus, S. J., Raskin, L., Rennert, G., Rennert, H. S., van Rensburg, E. J., Riggan, M. J., Risch, H. A., Risch, A., Roobol, M. J., Rosenstein, B. S., Rossing, M. A., De Ruyck, K., Saloustros, E., Sandler, D. P., Sawyer, E. J., Schabath, M. B., Schleutker, J., Schmidt, M. K., Setiawan, V. W., Shen, H., Siegel, E. M., Sieh, W., Singer, C. F., Slattery, M. L., Sorensen, K. D., Southey, M. C., Spurdle, A. B., Stanford, J. L., Stevens, V. L., Stintzing, S., Stone, J., Sundfeldt, K., Sutphen, R., Swerdlow, A. J., Tajara, E. H., Tangen, C. M., Tardon, A., Taylor, J. A., Teare, M. D., Teixeira, M. R., Terry, M. B., Terry, K. L., Thibodeau, S. N., Thomassen, M., Bjørge, L., Tischkowitz, M., Toland, A. E., Torres, D., Townsend, P. A., Travis, R. C., Tung, N., Tworoger, S. S., Ulrich, C. M., Usmani, N., Vachon, C. M., Van Nieuwenhuysen, E., Vega, A., Aguado-Barrera, M. E., Wang, Q., Webb, P. M., Weinberg, C. R., Weinstein, S., Weissler, M. C., Weitzel, J. N., West, C. M. L., White, E., Whittemore, A. S., Wichmann, H-E., Wiklund, F., Winqvist, R., Wolk, A., Woll, P., Woods, M., Wu, A. H., Wu, X., Yannoukakos, D., Zheng, W., Zienolddiny, S., Ziogas, A., Zorn, K. K., Lane, J. M., Saxena, R., Thomas, D., Hung, R. J., Diergaarde, B., McKay, J., Peters, U., Hsu, L., García-Closas, M., Eeles, R. A., Chenevix-Trench, G., Brennan, P. J., Haiman, C. A., Simard, J., Easton, D. F., Gruber, S. B., Pharoah, P. D. P., Price, A. L., Pasaniuc, B., Amos, C. I., Kraft, P. & Lindström, S., 25 Jan 2019, In : Nature Communications. 10, 1, p. 431

    Research output: Contribution to journal › Article

    DOI: 10.1038/s41467-018-08054-4
  9. Published

    Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study

    PRACTICAL Consortium, Jan 2019, In : Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 28, 1, p. 208-216 9 p.

    Research output: Contribution to journal › Article

    DOI: 10.1158/1055-9965.EPI-18-0079
  10. Published

    Guidelines for using sigQC for systematic evaluation of gene signatures

    Dhawan, A., Barberis, A., Cheng, W. C., Domingo, E., West, C., Maughan, T., Scott, J. G., Harris, A. L. & Buffa, F. M., 2019, In : Nature protocols.

    Research output: Contribution to journal › Article

    DOI: 10.1038/s41596-019-0136-8
  11. Published

    MRE11 as a predictive biomarker of outcome following radiotherapy in bladder cancer

    Walker, A. K., Karaszi, K., Valentine, H., Strauss, V. Y., Choudhury, A., McGill, S., Wen, K., Brown, M. D., Ramani, V., Bhattarai, S., Teo, M. T., Yang, L., Myers, K. A., Deshmukh, N., Denley, H., Browning, L., Love, S. B., Iyer, G., Clarke, N. W., Hall, E. & 5 othersHuddart, R., James, N. D., Hoskin, P. J., West, C. M. & Kiltie, A. E., 2019, In : International journal of radiation oncology, biology, physics.

    Research output: Contribution to journal › Article

    DOI: 10.1016/j.ijrobp.2019.03.015
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Publications highlights

Radiogenomics in the Era of Advanced Radiotherapy

Research output: Contribution to journal › Article

Shared heritability and functional enrichment across six solid cancers

Research output: Contribution to journal › Article

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study

Research output: Contribution to journal › Article

MRE11 as a predictive biomarker of outcome following radiotherapy in bladder cancer

Research output: Contribution to journal › Article

Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters

Research output: Contribution to journal › Article

Acute Epithelial Toxicity Is Prognostic for Improved Prostate Cancer Response to Radiation Therapy: A Retrospective, Multicenter, Cohort Study

Research output: Contribution to journal › Article

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Research output: Contribution to journal › Article

Precision Oncology and Genomically Guided Radiation Therapy: A Report From the American Society for Radiation Oncology/American Association of Physicists in Medicine/National Cancer Institute Precision Medicine Conference.

Research output: Contribution to journal › Article

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.

Research output: Contribution to journal › Article

Pre-treatment tumour perfusion parameters and initial RECIST response do not predict long-term survival outcomes for patients with head and neck squamous cell carcinoma treated with induction chemotherapy

Research output: Contribution to journal › Article

A new approach for modeling patient overall radiosensitivity and predicting multiple toxicity endpoints for breast cancer patients

Research output: Contribution to journal › Article

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Research output: Contribution to journal › Article

Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia

Research output: Contribution to journal › Article

Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Research output: Contribution to journal › Article

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

Research output: Contribution to journal › Article

Mapping Hypoxia in Renal Carcinoma with Oxygen-enhanced MRI: Comparison with Intrinsic Susceptibility MRI and Pathology

Research output: Contribution to journal › Article

Prospective evaluation of relationships between radiotherapy dose to masticatory apparatus and trismus

Research output: Contribution to journal › Article

Technical and biological validation of hypoxia PET imaging using [18F]fluroazomycin (FAZA) in NSCLC

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Use of a novel atlas for muscles of mastication to reduce inter observer variability in head and neck radiotherapy contouring

Research output: Contribution to journal › Article

Validation of a hypoxia related gene signature in multiple soft tissue sarcoma cohorts

Research output: Contribution to journal › Article

Radiogenomics and radiotherapy response modeling.

Research output: Contribution to journal › Article

Data-Based Radiation Oncology: Design of Clinical Trials in the Toxicity Biomarkers Era.

Research output: Contribution to journal › Article

A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High Risk Bladder Cancer Patients

Research output: Contribution to journal › Article

Distinct patterns of infiltrating CD8+ T cells in HPV+ and CD68 macrophages in HPV- oropharyngeal squamous cell carcinomas are associated with better clinical outcome but PD-L1 expression is not prognostic

Research output: Contribution to journal › Article

Ionizing radiation biomarkers in epidemiological studies - An update.

Research output: Contribution to journal › Article

Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility

Research output: Contribution to journal › Article

Taxane, platinum and 5-FU prior to chemoradiotherapy benefits patients with stage IV neck node-positive head and neck cancer and a good performance status

Research output: Contribution to journal › Article

The predictive and prognostic value of tumour necrosis in muscle invasive bladder cancer patients receiving radiotherapy with or without chemotherapy in the BC2001 trial (CRUK/01/004)

Research output: Contribution to journal › Article

The prognostic value of dynamic contrast-enhanced MRI contrast agent transfer constant Ktrans in cervical cancer is explained by plasma flow rather than vessel permeability

Research output: Contribution to journal › Article

Optimal design and patient selection for interventional trials using radiogenomic biomarkers: A REQUITE and Radiogenomics consortium statement

Research output: Contribution to journal › Review article

Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

Research output: Contribution to journal › Article

HPV-related oropharynx cancer in the United Kingdom: An evolution in the understanding of disease etiology

Research output: Contribution to journal › Article

Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas

Research output: Contribution to journal › Article

Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer

Research output: Contribution to journal › Article

Common genetic variation associated with increased susceptibility to prostate cancer does not increase risk of radiotherapy toxicity.

Research output: Contribution to journal › Article

Patients with a High Polygenic Risk of Breast Cancer do not have An Increased Risk of Radiotherapy Toxicity

Research output: Contribution to journal › Article

Pre-treatment lymphocytopaenia is an adverse prognostic biomarker in muscle-invasive and advanced bladder cancer

Research output: Contribution to journal › Article

Expression of miR-210 in relation to other measures of hypoxia and prediction of benefit from hypoxia modification in patients with bladder cancer

Research output: Contribution to journal › Article

FOXM1 and polo-like kinase 1 are co-ordinately overexpressed in patients with gastric adenocarcinomas

Research output: Contribution to journal › Article

Cediranib combined with carboplatin and paclitaxel in patients with metastatic or recurrent cervical cancer (CIRCCa): a randomised, double-blind, placebo-controlled phase 2 trial

Research output: Contribution to journal › Article

Improved accuracy and precision of tracer kinetic parameters by joint fitting to variable flip angle and dynamic contrast enhanced MRI data

Research output: Contribution to journal › Article

Biomarkers and Imaging for Precision Radiotherapy.

Research output: Contribution to journal › Article

XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients

Research output: Contribution to journal › Article

Incorporating Genetic Biomarkers into Predictive Models of Normal Tissue Toxicity

Research output: Contribution to journal › Article

Exploiting biological and physical determinants of radiotherapy toxicity to individualize treatment

Research output: Contribution to journal › Review article

Tumor plasma flow determined by dynamic contrast-enhanced MRI predicts response to induction chemotherapy in head and neck cancer

Research output: Contribution to journal › Article

Prognostic value of hypoxia-associated markers in advanced larynx and hypopharynx squamous cell carcinoma.

Research output: Contribution to journal › Article

Imaging tumour hypoxia with positron emission tomography

Research output: Contribution to journal › Article

Radiogenomics: the search for genetic predictors of radiotherapy response

Research output: Contribution to journal › Article

The REQUITE Project: Validating Predictive Models and Biomarkers of Radiotherapy Toxicity to Reduce Side-effects and Improve Quality of Life in Cancer Survivors

Research output: Contribution to journal › Editorial

Dynamic contrast-enhanced magnetic resonance imaging biomarkers in head and neck cancer: Potential to guide treatment? A systematic review

Research output: Contribution to journal › Article

Radiogenomics: radiobiology enters the era of big data and team science

Research output: Contribution to journal › Article

Expression of hypoxia-inducible factor-1α predicts benefit from hypoxia modification in invasive bladder cancer

Research output: Contribution to journal › Article

FGFR2, HER2 and cMet in gastric adenocarcinoma: Detection, prognostic significance and assessment of downstream pathway activation

Research output: Contribution to journal › Article

Investigation of radiosensitivity gene signatures in cancer cell lines

Research output: Contribution to journal › Article

A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity

Research output: Contribution to journal › Article

A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1

Research output: Contribution to journal › Article

Investigation of the epithelial to mesenchymal transition markers S100A4, vimentin and Snail1 in gastroesophageal junction tumors

Research output: Contribution to journal › Article

Loss of expression of the tumour suppressor gene AIMP3 predicts survival following radiotherapy in muscle-invasive bladder cancer

Research output: Contribution to journal › Article

NIMRAD – A Phase III Trial to Investigate the Use of Nimorazole Hypoxia Modification with Intensity-modulated Radiotherapy in Head and Neck Cancer

Research output: Contribution to journal › Article

Phase II Trial of Cetuximab and Conformal Radiotherapy Only in Locally Advanced Pancreatic Cancer with Concurrent Tissue Sampling Feasibility Study

Research output: Contribution to journal › Article

STROGAR - STrengthening the Reporting of Genetic Association studies in Radiogenomics

Research output: Contribution to journal › Article

Molecular and cellular processes underlying the hallmarks of head and neck cancer

Research output: Contribution to journal › Article

The case for including bowel urgency in toxicity reporting after pelvic cancer treatment

Research output: Contribution to journal › Article

Necrosis predicts benefit from hypoxia-modifying therapy in patients with high risk bladder cancer enrolled in a phase III randomised trial

Research output: Contribution to journal › Article

RAPPER: the radiogenomics of radiation toxicity

Research output: Contribution to journal › Article

Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivity

Research output: Contribution to journal › Article

FTIR microspectroscopy of selected rare diverse sub-variants of carcinoma of the urinary bladder.

Research output: Contribution to journal › Article

Lack of Prognostic Effect of Carbonic Anhydrase-9, Hypoxia Inducible Factor-1α and Bcl-2 in 286 Patients with Early Squamous Cell Carcinoma of the Glottic Larynx Treated with Radiotherapy

Research output: Contribution to journal › Article

A pilot study to investigate the role of thymidylate synthase as a marker of prognosis for neoadjuvant chemotherapy in gastric and gastro-oesophageal junction adenocarcinoma

Research output: Contribution to journal › Article

The prognostic significance of the biomarker p16 in oropharyngeal squamous cell carcinoma.

Research output: Contribution to journal › Article

Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity

Research output: Contribution to journal › Article

Will SNPs be useful predictors of normal tissue radiosensitivity in the future?

Research output: Contribution to journal › Article

The FOXM1-PLK1 axis is commonly upregulated in oesophageal adenocarcinoma

Research output: Contribution to journal › Article

Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population

Research output: Contribution to journal › Article

Assessment of Histopathological Response in Gastric and Gastro-Oesophageal Junction Adenocarcinoma following Neoadjuvant Chemotherapy: Which Scoring System to Use?

Research output: Contribution to journal › Article

A replicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy

Research output: Contribution to journal › Article

Enhanced stability of microRNA expression facilitates classification of FFPE tumour samples exhibiting near total mRNA degradation

Research output: Contribution to journal › Article

Lack of Prognostic Effect of Carbonic Anhydrase-9, Hypoxia Inducible Factor-1α and Bcl-2 in 286 Patients with Early Squamous Cell Carcinoma of the Glottic Larynx Treated with Radiotherapy

Research output: Contribution to journal › Article

Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery.

Research output: Contribution to journal › Article

Osteoradionecrosis in head-and-neck cancer has a distinct genotype-dependent cause.

Research output: Contribution to journal › Article

Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: A prospective analysis study

Research output: Contribution to journal › Article

Perfusion estimated with rapid dynamic contrast-enhanced magnetic resonance imaging correlates inversely with vascular endothelial growth factor expression and pimonidazole staining in head-and-neck cancer: A pilot study

Research output: Contribution to journal › Article

Genetics and genomics of radiotherapy toxicity: Towards prediction

Research output: Contribution to journal › Article

Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: A cohort study based on 994 patients

Research output: Contribution to journal › Article

The STAT Score: A cumulative score of radiation toxicity for use in radiogenomics studies.

Research output: Contribution to journal › Article

Mitochondrial DNA mutations in head and neck cancer are infrequent and lack prognostic utility.

Research output: Contribution to journal › Article

The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis

Research output: Contribution to journal › Article

Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples

Research output: Contribution to journal › Article

Molecular targeting for improving the outcome of radiotherapy

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Development of a patient-reported questionnaire for collecting toxicity data following prostate brachytherapy

Research output: Contribution to journal › Article

Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene

Research output: Contribution to journal › Comment/debate

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

Research output: Contribution to journal › Article

Radiation and the genome: From risks to opportunities for therapeutic exploitation

Research output: Contribution to journal › Article

Spectral clustering of microarray data elucidates the roles of microenvironment remodeling and immune responses in survival of head and neck squamous cell carcinoma

Research output: Contribution to journal › Article

Tumour budding and a low host inflammatory response are associated with a poor prognosis in oesophageal and gastro-oesophageal junction cancers.

Research output: Contribution to journal › Article

Use of multiple biological markers in radiotherapy-treated head and neck cancer.

Research output: Contribution to journal › Article

hsa-mir-210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer.

Research output: Contribution to journal › Article

Computed tomography overestimation of esophageal tumor length: Implications for radiotherapy planning.

Research output: Contribution to journal › Article

Establishment of a Radiogenomics Consortium

Research output: Contribution to journal › Editorial

A comparison of tracer kinetic models for T1-weighted dynamic contrast-enhanced MRI: application in carcinoma of the cervix.

Research output: Contribution to journal › Article

Expression of hypoxia-inducible factor 1α in thyroid carcinomas

Research output: Contribution to journal › Article

No association between SNPs regulating TGF-beta1 secretion and late radiotherapy toxicity to the breast: Results from the RAPPER study.

Research output: Contribution to journal › Article

Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix

Research output: Contribution to journal › Article

Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene

Research output: Contribution to journal › Article

Head and neck cancer--Part 1: Epidemiology, presentation, and prevention.

Research output: Contribution to journal › Article

Head and neck cancer--Part 2: Treatment and prognostic factors.

Research output: Contribution to journal › Article

Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors

Research output: Contribution to journal › Article

The degree of circumferential tumour involvement as a prognostic factor in oesophageal cancer

Research output: Contribution to journal › Article

Point: Why choose pulsed-dose-rate brachytherapy for treating gynecologic cancers?

Research output: Contribution to journal › Article

21st L H Gray Conference: The radiobiology/radiation protection interface

Research output: Contribution to journal › Article

Clinical impact of tomour involvement of the anastomotic doughnut in oesophagogastric cancer surgery

Research output: Contribution to journal › Article

Measurement tools for gastrointestinal symptoms in radiation oncology

Research output: Contribution to journal › Article

Blood flow and vd (water): Both biomarkers required for interpreting the effects of vascular targeting agents on tumor and normal tissue

Research output: Contribution to journal › Article

Normal tissue reactions to radiotherapy: Towards tailoring treatment dose by genotype

Research output: Contribution to journal › Article

Comparison of predicted and clinical response to radiotherapy: A radiobiology modelling study

Research output: Contribution to journal › Article

Prognostic Significance of Tumor Hypoxia Inducible Factor-1α Expression for Outcome After Radiotherapy in Oropharyngeal Cancer

Research output: Contribution to journal › Article

Epidermal growth factor receptor-targeted therapy

Research output: Contribution to journal › Article

No relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma

Research output: Contribution to journal › Article

Hypoxia-associated markers in gastric carcinogenesis and HIF-2α in gastric and gastro-oesophageal cancer prognosis

Research output: Contribution to journal › Article

Exploiting sample variability to enhance multivariate analysis of microarray data

Research output: Contribution to journal › Article

Clinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: A review

Research output: Contribution to journal › Article

Tumor Epression of Major Vault Protein is an Adverse Prognostic Factor for Radiotherapy Outcome in Oropharyngeal Carcinoma

Research output: Contribution to journal › Article

The Genomics Revolution and Radiotherapy

Research output: Contribution to journal › Article

Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence.

Research output: Contribution to journal › Article

Hypoxia-inducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas.

Research output: Contribution to journal › Article

Expression of vascular endothelial growth factor (VEGF) in locally invasive prostate cancer is prognostic for radiotherapy outcome

Research output: Contribution to journal › Article

Radiotherapy predictive assays

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Early change in glucose metabolic rate measured using FDG-PET in patients with high-grade glioma predicts response to temozolomide but not temozolomide plus radiotherapy

Research output: Contribution to journal › Article

Hypoxia in head and neck cancer

Research output: Contribution to journal › Article

Radiosensitivity, Radiogenomics and RAPPER

Research output: Contribution to journal › Article

Translational research in radiotherapy trials

Research output: Contribution to journal › Article

The prognostic value of pimonidazole and tumour pO 2 in human cervix carcinomas after radiation therapy: A prospective international multi-center study

Research output: Contribution to journal › Article

Imaging vascular physiology to monitor cancer treatment

Research output: Contribution to journal › Article

No relationship between thymidine phosphorylase (TP, PD-ECGF) expression and hypoxia in carcinoma of the cervix

Research output: Contribution to journal › Article

Thoracic radiotherapy for limited-stage small-cell lung cancer: Controversies and future developments

Research output: Contribution to journal › Article

Molecular markers predicting radiotherapy response: Report and recommendations from an International Atomic Energy Agency technical meeting

Research output: Contribution to journal › Article

Thoracic radiation therapy for limited-stage small-cell lung cancer: Unanswered questions

Research output: Contribution to journal › Article

Hypoxia-regulated glucose transporter Glut-1 may influence chemosensitivity to some alkylating agents: results of EORTC (First Translational Award) study of the relevance of tumour hypoxia to the outcome of chemotherapy in human tumour-derived xenografts.

Research output: Contribution to journal › Article

Expression of the proapoptotic protein Bid is an adverse prognostic factor for radiotherapy outcome in carcinoma of the cervix

Research output: Contribution to journal › Article

The potential of PET to increase understanding of the biological basis of tumour and normal tissue response to radiotherapy

Research output: Contribution to journal › Article

Measuring tumor pharmacodynamic response using PET proliferation probes: the case for 2-[(11)C]-thymidine.

Research output: Contribution to journal › Article

Hypoxia-inducible factor 1α expression as an intrinsic marker of hypoxia: Correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix

Research output: Contribution to journal › Article

The potential of positron-emission tomography to study anticancer-drug resistance

Research output: Contribution to journal › Article

Combretastatin A4 phosphate.

Research output: Contribution to journal › Article

Cytotoxicity of the bioreductive agent RH1 and its lack of interaction with radiation

Research output: Contribution to journal › Article

Positron Emission Tomography (PET) and anticancer drug development

Research output: Contribution to journal › Article

Assessment of morbidity in carcinoma of the cervix: A comparison of the LENT SOMA scales and the Franco-Italian glossary

Research output: Contribution to journal › Article

Glucose transporter-1 (GLUT-1): A potential marker of prognosis in rectal carcinoma?

Research output: Contribution to journal › Article

Evaluation of the LENT-SOMA scales for the prospective assessment of treatment morbidity in cervical carcinoma

Research output: Contribution to journal › Article

Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas

Research output: Contribution to journal › Article

Glut-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding

Research output: Contribution to journal › Article

Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients

Research output: Contribution to journal › Article

Late radiation morbidity in a patient with carcinoma of the cervix

Research output: Contribution to journal › Article

Short report: A morbidity scoring system for clinical oncology practice: Questionaires produced from the LENT SOMA scoring system

Research output: Contribution to journal › Article

Chromosomal radiosensitivity in young cancer patients: Possible evidence of genetic predisposition

Research output: Contribution to journal › Article

Differential expression of cytokine genes in fibroblasts derived from skin biopsies of patients who developed minimal or severe normal tissue damage after radiotherapy

Research output: Contribution to journal › Article

Relationship between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiation reactions: A comparison of training and validation cohorts of breast cancer patients

Research output: Contribution to journal › Article

Correspondence re: A. Rothfuss et al., Induced micronucleus frequencies in peripheral blood lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer res., 60: 390-394, 2000 [1]

Research output: Contribution to journal › Article

Incorporating biologic measurements (SF2, CFE) into a tumor control probability model increases their prognostic significance: A study in cervical carcinoma treated with radiation therapy

Research output: Contribution to journal › Article

Ability to undergo apoptosis does not correlate with the intrinsic radiosensitivity (SF2) of human cervix tumor cell lines

Research output: Contribution to journal › Article

Chromosomal radiosensitivity as a marker of predisposition to common cancers?

Research output: Contribution to journal › Article

Tumor vascularity: A histological measure of angiogenesis and hypoxia

Research output: Contribution to journal › Article

Radiation response and cure rate of human colon adenocarcinoma spheroids of different size: The significance of hypoxia on tumor control modelling

Research output: Contribution to journal › Article

Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma

Research output: Contribution to journal › Article

Prediction of clinical outcome for cancer of the cervix using dynamic contrast enhanced MR imaging

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Relationships between clonogenic cell survival, DNA damage and chromosomal radiosensitivity in nine human cervix carcinoma cell lines

Research output: Contribution to journal › Article

Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix

Research output: Contribution to journal › Article

Detection of individual differences in radiation-induced apoptosis of peripheral blood lymphocytes in normal individuals, ataxia telangiectasia homozygotes and heterozygotes, and breast cancer patients after radiotherapy

Research output: Contribution to journal › Article

Tumor radiosensitivity (SF2) is a prognostic factor for local control in head and neck cancers

Research output: Contribution to journal › Article

Expression of Ku70 correlates with survival in carcinoma of the cervix

Research output: Contribution to journal › Article

Pretreatment plasma TGFb1 levels are prognostic for survival but not morbidity following radiation therapy of carcinoma of the cervix

Research output: Contribution to journal › Article

Vascular endothelial growth factor (VEGF) expression is a prognostic factor for radiotherapy outcome in advanced carcinoma of the cervix.

Research output: Contribution to journal › Article

The immunohistochemical expression of DNA-PKcs and Ku (p70/p80) in head and neck cancers: relationships with radiosensitivity

Research output: Contribution to journal › Article

Changes in oxygenation during radiotherapy in carcinoma of the cervix

Research output: Contribution to journal › Article

A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinoma

Research output: Contribution to journal › Article

A correlation between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiotherapy reactions in breast cancer patients

Research output: Contribution to journal › Article

Lack of correlation between residual radiation-induced DNA damage, in keratinocytes assayed directly from skin, and late radiotherapy reactions in breast cancer patients

Research output: Contribution to journal › Article

Fibroblast radiosensitivity measured using the comet DNA-damage assay correlates with clonogenic survival parameters

Research output: Contribution to journal › Article

Prognostic significance of c-erbB-2 protein expression in carcinoma of the cervix treated with radiotherapy

Research output: Contribution to journal › Article

The lack of correlation between proliferation (Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancers

Research output: Contribution to journal › Article

The potential benefit from individualised radiotherapy scheduling for head and neck tumours on the basis of both histological grade and kinetics

Research output: Contribution to journal › Article

Tumour reoxygenation during radiotherapy in carcinoma of the cervix

Research output: Contribution to journal › Article

Tumour vascularity is a significant prognostic factor for cervix carcinoma treated with radiotherapy: Independence from tumour radiosensitivity

Research output: Contribution to journal › Article

Research Explorer downloads

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FTIR microspectroscopy of selected rare diverse sub-variants of carcinoma of the urinary bladder.

Research output: Contribution to journal › Article

114
A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High Risk Bladder Cancer Patients

Research output: Contribution to journal › Article

78
HPV-related oropharynx cancer in the United Kingdom: An evolution in the understanding of disease etiology

Research output: Contribution to journal › Article

71
Investigation of radiosensitivity gene signatures in cancer cell lines

Research output: Contribution to journal › Article

55
Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

Research output: Contribution to journal › Article