Dr Bruno M SimõesPhD

Research Fellow

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Publications

  1. 2018
  2. Published

    Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP

    Piggott, L., Silva, A., Robinson, T., Santiago-Gómez, A., Simões, B. M., Becker, M., Fichtner, I., Andera, L., Young, P., Morris, C., Barrett-Lee, P., Alchami, F., Piva, M., Vivanco, M. DM., Clarke, R. B., Gee, J. & Clarkson, R., 15 May 2018, In : Clinical Cancer Research. 24, 10, p. 2452-2463 12 p.

    Research output: Contribution to journalArticle

  3. Published

    Ethnicity influences breast cancer stem cells' drug resistance

    Kamal, M., Nafie, E. H. O., Elsers, S., Alanwar, S., Ibrahim, R., Farag, F., Mlees, M., Simões, B. M., Spence, K., Santiago-Gómez, A., Salem, M. L. & Clarke, R. B., Jul 2018, In : Breast Journal. 24, 4, p. 701-703 3 p.

    Research output: Contribution to journalArticle

  4. 2019
  5. Published

    A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells

    Domenici, G., Aurrekoetxea-Rodríguez, I., Simões, B. M., Rábano, M., Lee, S. Y., Millán, J. S., Comaills, V., Oliemuller, E., López-Ruiz, J. A., Zabalza, I., Howard, B. A., Kypta, R. M. & Vivanco, M. DM., 2019, In : Oncogene.

    Research output: Contribution to journalArticle

  6. Published

    FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4

    McClements, L., Annett, S., Yakkundi, A., O'Rourke, M., Valentine, A., Moustafa, N., Alqudah, A., Simões, B. M., Furlong, F., Short, A., McIntosh, S. A., McCarthy, H. O., Clarke, R. B. & Robson, T., 2019, In : BMC Cancer. 19, 1, 351.

    Research output: Contribution to journalArticle

  7. Published

    Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer

    Bacci, M., Lorito, N., Ippolito, L., Ramazzotti, M., Luti, S., Romagnoli, S., Parri, M., Bianchini, F., Cappellesso, F., Virga, F., Gao, Q., M Simoes, B., Marangoni, E., Martin, L-A., Comito, G., Ferracin, M., Giannoni, E., Mazzone, M., Chiarugi, P. & Morandi, A., 2 Jul 2019, In : Cell Reports. 28, 1, p. 104-118

    Research output: Contribution to journalArticle

  8. Published

    PAK4 regulates stemness and progression in endocrine resistant ERpositive metastatic breast cancer

    Santiago-Gómez, A., Kedward, T., M Simoes, B., Dragoni, I., NicAmhlaoibh, R., Trivier, E., Sabin, V., Gee, J. M., Sims, A. H., Howell, S. J. & Clarke, R. B., 28 Aug 2019, In : Cancer Letters. 11 p., 10.1016/j.canlet.2019.05.014.

    Research output: Contribution to journalArticle

  9. Published

    Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

    Eyre, R., Alferez-Castro, D., Santiago-Gómez, A., Spence, K., Mcconnell, J., Hart, C., M Simoes, B., Lefley, D., Tulotta, C., Storer, J., Gurney, A., Clarke, N., Brown, M., Howell, S., Sims, A. H., Farnie, G., Ottewell, P. D. & Clarke, R. B., 1 Nov 2019, In : Nature Communications. 10, 1, p. 5016 15 p.

    Research output: Contribution to journalArticle

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