Dr Bruno M SimõesPhD

Research Fellow

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Publications

  1. 2011
  2. Published

    Cancer stem cells in the human mammary gland and regulation of their differentiation by estrogen

    Simões, B. M. & Vivanco, M. D., Aug 2011, In : Future Oncology. 7, 8, p. 995-1006 11 p.

    Research output: Contribution to journalArticle

  3. Published

    Effects of estrogen on the proportion of stem cells in the breast

    Simões, B. M., Piva, M., Iriondo, O., Comaills, V., López-Ruiz, J. A., Zabalza, I., Mieza, J. A., Acinas, O. & Vivanco, M. D. M., Aug 2011, In : Breast Cancer Research and Treatment. 129, 1, p. 23-35 12 p.

    Research output: Contribution to journalArticle

  4. 2012
  5. Published

    A detailed mammosphere assay protocol for the quantification of breast stem cell activity

    Shaw, F. L., Harrison, H., Spence, K., Ablett, M. P., Simões, B. M., Farnie, G. & Clarke, R. B., Jun 2012, In : Journal of Mammary Gland Biology and Neoplasia. 17, 2, p. 111-117 6 p.

    Research output: Contribution to journalArticle

  6. 2013
  7. Published

    Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms.

    Singh, J. K., Farnie, G., Bundred, N. J., Simões, B. M., Shergill, A., Landberg, G., Howell, S. J. & Clarke, R. B., 1 Feb 2013, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 19, 3, p. 643-656 13 p.

    Research output: Contribution to journalArticle

  8. Published

    Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling

    Harrison, H., Simões, B. M., Rogerson, L., Howell, S. J., Landberg, G. & Clarke, R. B., 8 Mar 2013, In : Breast Cancer Research. 15, 2, R21.

    Research output: Contribution to journalArticle

  9. Published

    Recent Advances Reveal IL-8 Signalling as a Potential Key to Targeting Breast Cancer Stem Cells

    Singh, J., Simões, B. M., Howell, S., Farnie, G. & Clarke, RB., 30 Aug 2013, In : Breast Cancer Research. 15, 4, p. 210 210.

    Research output: Contribution to journalArticle

  10. Published

    Targeting IL-8 signalling to inhibit breast cancer stem cell activity

    Singh, J. K., Simões, B. M., Clarke, R. B. & Bundred, N. J., Nov 2013, In : Expert Opinion on Therapeutic Targets. 17, 11, p. 1235-1241 6 p.

    Research output: Contribution to journalArticle

  11. Published

    Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity

    Yu, L., Liu, S., Zhang, C., Zhang, B., Simões, B. M., Eyre, R., Liang, Y., Yan, H., Wu, Z., Guo, W. & Clarke, R., Dec 2013, In : Oncotarget. 4, 12, p. 2326-2338 12 p.

    Research output: Contribution to journalArticle

  12. 2014
  13. Published

    Sox2 promotes tamoxifen resistance in breast cancer cells

    Piva, M., Domenici, G., Iriondo, O., Rábano, M., Simões, B. M., Comaills, V., Barredo, I., López-Ruiz, J. A., Zabalza, I., Kypta, R. & Vivanco, M. D. M., Jan 2014, In : EMBO Molecular Medicine . 6, 1, p. 66-79 13 p.

    Research output: Contribution to journalArticle

  14. Published

    Breast cancer stem-like cell activity correlates with tumour progression to metastasis but not with clinical or tumour characteristics

    Howell, SJ., Alferez, D., Spence, K., Eyre, R., Shaw, F., Simões, B. M., Santiago-Gomez, A., Bramley, M., Absar, M., Saad, Z., Chatterjee, S., Kirwan, C., Gandhi, A., Armstrong, AC., Wardley, AM., Farnie, G. & Clarke, R., Dec 2014.

    Research output: Contribution to conferencePoster

  15. 2015
  16. Published

    The role of steroid hormones in breast cancer stem cells

    Simões, B. M., Alferez, D., Howell, S. & Clarke, R., 17 Sep 2015, In : Endocrine-related cancer. 22 (6):T177-86, 6, p. 177-186 9 p., ERC-15-0350.

    Research output: Contribution to journalArticle

  17. Published

    Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.

    M Simoes, B., O'Brien, C., Eyre, R., Silva, A., Yu, L., Sarmiento Castro, A., Alferez-Castro, D., Spence, K., Santiago-Gomez, A., Chemi, F., Acar, A., Gandhi, A., Howell, A., Brennan, K., Rydén, L., Catalano, S., Andó, S., Gee, J., Ucar, A., Sims, A. H. & 5 others, Marangoni, E., Farnie, G., Landberg, G., Howell, S. & Clarke, R. B., 29 Sep 2015, In : Cell Reports. 12, 12, p. 1968-1977 9 p.

    Research output: Contribution to journalArticle

  18. 2016
  19. Published

    A Role for Notch Signalling in Breast Cancer and Endocrine Resistance.

    Acar, A., Simões, B. M., Clarke, R. B. & Brennan, K., 2016, In : Stem cells international. 2016

    Research output: Contribution to journalArticle

  20. Published

    Leptin as a mediator of tumor-stromal interactions promotes breast cancer stem cell activity.

    Giordano, C., Chemi, F., Panza, S., Bonofiglio, D., Lanzino, M., Cordella, A., Campana, A., Hashim, A., Rizza, P., Győrffy, B., Simões, B. M., Clarke, R., Weisz, A., Catalano, S. & Andò, S., 12 Jan 2016, In : Oncotarget. 7, 2, p. 1262-1275 13 p.

    Research output: Contribution to journalArticle

  21. Published

    Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells.

    Aires, A., Ocampo, S. M., Simões, B. M., Josefa Rodríguez, M., Couleaud, P., Spence, K., Latorre, A., Miranda, R., Somoza, Á., Clarke, R., Carrascosa, J. L. & Cortajarena, A. L., 12 Feb 2016, In : Nanotechnology. 27, 6, p. 065103

    Research output: Contribution to journalArticle

  22. Published

    Cisplatin selects for stem-like cells in osteosarcoma by activating notch signaling

    Yu, L., Fan, Z., Fang, S., Yang, J., Gao, T., Simões, B. M., Eyre, R., Guo, W. & Clarke, R. B., 20 Apr 2016, In : Oncotarget.

    Research output: Contribution to journalArticle

  23. Published

    Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis

    Eyre, R., Alférez, D. G., Spence, K., Kamal, M., Shaw, F. L., Simões, B. M., Santiago-Gómez, A., Sarmiento-Castro, A., Bramley, M., Absar, M., Saad, Z., Chatterjee, S., Kirwan, C., Gandhi, A., Armstrong, A. C., Wardley, A. M., O'Brien, C. S., Farnie, G., Howell, S. J. & Clarke, R. B., 28 Sep 2016, In : Journal of Mammary Gland Biology and Neoplasia.

    Research output: Contribution to journalArticle

  24. 2017
  25. Published

    Targeting IL-1 beta-Wnt signalling to prevent breast cancer colonisation in the bone microenvironment

    Eyre, R., Alferez, D., Santiago-Gomez, A., Spence, K., McConnell, J., Simoes, B., Hart, C., Lefley, D., Tulotta, C., Gurney, A., Howell, S., Brown, M., Sims, A., Farnie, G., Ottewell, P. & Clarke, R., Dec 2017, In : Clinical and Experimental Metastasis. 34, 8, p. 493-493

    Research output: Contribution to journalMeeting Abstract

  26. 2018
  27. Published

    Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors

    M Simoes, B., Kohler, B., Clarke, R. B., Stringer, J., Novak Frazer, L., Young, K., Richardson, R., Zucchini, G., Armstrong, A. & Howell, S., 2018, In : Therapeutic Advances in Medical Oncology. 10

    Research output: Contribution to journalArticle

  28. Published

    The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells

    Alferez-Castro, D., M Simoes, B., Howell, S. & Clarke, R., 2018, In : Current Stem Cell Reports.

    Research output: Contribution to journalArticle

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Research output: Contribution to journalArticle