Dr Bruno M SimõesPhD

Research Fellow

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Publications

  1. Published

    A Role for Notch Signalling in Breast Cancer and Endocrine Resistance.

    Acar, A., Simões, B. M., Clarke, R. B. & Brennan, K., 2016, In : Stem cells international. 2016

    Research output: Contribution to journalArticle

  2. Published

    Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells.

    Aires, A., Ocampo, S. M., Simões, B. M., Josefa Rodríguez, M., Couleaud, P., Spence, K., Latorre, A., Miranda, R., Somoza, Á., Clarke, R., Carrascosa, J. L. & Cortajarena, A. L., 12 Feb 2016, In : Nanotechnology. 27, 6, p. 065103

    Research output: Contribution to journalArticle

  3. Published

    The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells

    Alferez-Castro, D., M Simoes, B., Howell, S. & Clarke, R., 2018, In : Current Stem Cell Reports.

    Research output: Contribution to journalArticle

  4. Published

    Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer

    Bacci, M., Lorito, N., Ippolito, L., Ramazzotti, M., Luti, S., Romagnoli, S., Parri, M., Bianchini, F., Cappellesso, F., Virga, F., Gao, Q., M Simoes, B., Marangoni, E., Martin, L-A., Comito, G., Ferracin, M., Giannoni, E., Mazzone, M., Chiarugi, P. & Morandi, A., 2 Jul 2019, In : Cell Reports. 28, 1, p. 104-118

    Research output: Contribution to journalArticle

  5. Published

    A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells

    Domenici, G., Aurrekoetxea-Rodríguez, I., Simões, B. M., Rábano, M., Lee, S. Y., Millán, J. S., Comaills, V., Oliemuller, E., López-Ruiz, J. A., Zabalza, I., Howard, B. A., Kypta, R. M. & Vivanco, M. DM., 2019, In : Oncogene.

    Research output: Contribution to journalArticle

  6. Published

    Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis

    Eyre, R., Alférez, D. G., Spence, K., Kamal, M., Shaw, F. L., Simões, B. M., Santiago-Gómez, A., Sarmiento-Castro, A., Bramley, M., Absar, M., Saad, Z., Chatterjee, S., Kirwan, C., Gandhi, A., Armstrong, A. C., Wardley, A. M., O'Brien, C. S., Farnie, G., Howell, S. J. & Clarke, R. B., 28 Sep 2016, In : Journal of Mammary Gland Biology and Neoplasia.

    Research output: Contribution to journalArticle

  7. Published

    Targeting IL-1 beta-Wnt signalling to prevent breast cancer colonisation in the bone microenvironment

    Eyre, R., Alferez, D., Santiago-Gomez, A., Spence, K., McConnell, J., Simoes, B., Hart, C., Lefley, D., Tulotta, C., Gurney, A., Howell, S., Brown, M., Sims, A., Farnie, G., Ottewell, P. & Clarke, R., Dec 2017, In : Clinical and Experimental Metastasis. 34, 8, p. 493-493

    Research output: Contribution to journalMeeting Abstract

  8. Published

    Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

    Eyre, R., Alferez-Castro, D., Santiago-Gómez, A., Spence, K., Mcconnell, J., Hart, C., M Simoes, B., Lefley, D., Tulotta, C., Storer, J., Gurney, A., Clarke, N., Brown, M., Howell, S., Sims, A. H., Farnie, G., Ottewell, P. D. & Clarke, R. B., 1 Nov 2019, In : Nature Communications. 10, 1, p. 5016 15 p.

    Research output: Contribution to journalArticle

  9. Published

    Leptin as a mediator of tumor-stromal interactions promotes breast cancer stem cell activity.

    Giordano, C., Chemi, F., Panza, S., Bonofiglio, D., Lanzino, M., Cordella, A., Campana, A., Hashim, A., Rizza, P., Győrffy, B., Simões, B. M., Clarke, R., Weisz, A., Catalano, S. & Andò, S., 12 Jan 2016, In : Oncotarget. 7, 2, p. 1262-1275 13 p.

    Research output: Contribution to journalArticle

  10. Published

    Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling

    Harrison, H., Simões, B. M., Rogerson, L., Howell, S. J., Landberg, G. & Clarke, R. B., 8 Mar 2013, In : Breast Cancer Research. 15, 2, R21.

    Research output: Contribution to journalArticle

  11. Published

    Breast cancer stem-like cell activity correlates with tumour progression to metastasis but not with clinical or tumour characteristics

    Howell, SJ., Alferez, D., Spence, K., Eyre, R., Shaw, F., Simões, B. M., Santiago-Gomez, A., Bramley, M., Absar, M., Saad, Z., Chatterjee, S., Kirwan, C., Gandhi, A., Armstrong, AC., Wardley, AM., Farnie, G. & Clarke, R., Dec 2014.

    Research output: Contribution to conferencePoster

  12. Published

    Ethnicity influences breast cancer stem cells' drug resistance

    Kamal, M., Nafie, E. H. O., Elsers, S., Alanwar, S., Ibrahim, R., Farag, F., Mlees, M., Simões, B. M., Spence, K., Santiago-Gómez, A., Salem, M. L. & Clarke, R. B., Jul 2018, In : Breast Journal. 24, 4, p. 701-703 3 p.

    Research output: Contribution to journalArticle

  13. Published

    Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.

    M Simoes, B., O'Brien, C., Eyre, R., Silva, A., Yu, L., Sarmiento Castro, A., Alferez-Castro, D., Spence, K., Santiago-Gomez, A., Chemi, F., Acar, A., Gandhi, A., Howell, A., Brennan, K., Rydén, L., Catalano, S., Andó, S., Gee, J., Ucar, A., Sims, A. H. & 5 others, Marangoni, E., Farnie, G., Landberg, G., Howell, S. & Clarke, R. B., 29 Sep 2015, In : Cell Reports. 12, 12, p. 1968-1977 9 p.

    Research output: Contribution to journalArticle

  14. Published

    Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors

    M Simoes, B., Kohler, B., Clarke, R. B., Stringer, J., Novak Frazer, L., Young, K., Richardson, R., Zucchini, G., Armstrong, A. & Howell, S., 2018, In : Therapeutic Advances in Medical Oncology. 10

    Research output: Contribution to journalArticle

  15. Published

    FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4

    McClements, L., Annett, S., Yakkundi, A., O'Rourke, M., Valentine, A., Moustafa, N., Alqudah, A., Simões, B. M., Furlong, F., Short, A., McIntosh, S. A., McCarthy, H. O., Clarke, R. B. & Robson, T., 2019, In : BMC Cancer. 19, 1, 351.

    Research output: Contribution to journalArticle

  16. Published

    Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP

    Piggott, L., Silva, A., Robinson, T., Santiago-Gómez, A., Simões, B. M., Becker, M., Fichtner, I., Andera, L., Young, P., Morris, C., Barrett-Lee, P., Alchami, F., Piva, M., Vivanco, M. DM., Clarke, R. B., Gee, J. & Clarkson, R., 15 May 2018, In : Clinical Cancer Research. 24, 10, p. 2452-2463 12 p.

    Research output: Contribution to journalArticle

  17. Published

    Sox2 promotes tamoxifen resistance in breast cancer cells

    Piva, M., Domenici, G., Iriondo, O., Rábano, M., Simões, B. M., Comaills, V., Barredo, I., López-Ruiz, J. A., Zabalza, I., Kypta, R. & Vivanco, M. D. M., Jan 2014, In : EMBO Molecular Medicine . 6, 1, p. 66-79 13 p.

    Research output: Contribution to journalArticle

  18. Published

    PAK4 regulates stemness and progression in endocrine resistant ERpositive metastatic breast cancer

    Santiago-Gómez, A., Kedward, T., M Simoes, B., Dragoni, I., NicAmhlaoibh, R., Trivier, E., Sabin, V., Gee, J. M., Sims, A. H., Howell, S. J. & Clarke, R. B., 28 Aug 2019, In : Cancer Letters. 11 p., 10.1016/j.canlet.2019.05.014.

    Research output: Contribution to journalArticle

  19. Published

    A detailed mammosphere assay protocol for the quantification of breast stem cell activity

    Shaw, F. L., Harrison, H., Spence, K., Ablett, M. P., Simões, B. M., Farnie, G. & Clarke, R. B., Jun 2012, In : Journal of Mammary Gland Biology and Neoplasia. 17, 2, p. 111-117 6 p.

    Research output: Contribution to journalArticle

  20. Published

    The role of steroid hormones in breast cancer stem cells

    Simões, B. M., Alferez, D., Howell, S. & Clarke, R., 17 Sep 2015, In : Endocrine-related cancer. 22 (6):T177-86, 6, p. 177-186 9 p., ERC-15-0350.

    Research output: Contribution to journalArticle

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