Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

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Publications

  1. 2003
  2. Published

    Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice

    Waddington, S. N., Mitrophanous, K. A., Ellard, F. M., Buckley, S. M. K., Nivsarkar, M., Lawrence, L., Cook, H. T., Al-Allaf, F., Bigger, B., Kingsman, S. M., Coutelle, C. & Themis, M., Aug 2003, In: Gene Therapy. 10, 15, p. 1234-1240 6 p.

    Research output: Contribution to journalArticlepeer-review

  3. Published

    Gene Therapy for Mitochondrial DNA Disorders

    Bigger, B., Lightowlers, R. N., Taylor, R. W., Turnbull, D. & Holt, IJ. (ed.), 2003, Genetics of Mitochondrial Diseases. Oxford: Oxford University Press

    Research output: Chapter in Book/Report/Conference proceedingChapter

  4. 2001
  5. Published

    An araC-controlled Bacterial cre Expression System to Produce DNA Minicircle Vectors for Nuclear and Mitochondrial Gene Therapy

    Bigger, B. W., Tolmachov, O., Collombet, J. M., Fragkos, M., Palaszewski, I. & Coutelle, C., 22 Jun 2001, In: Journal of Biological Chemistry. 276, 25, p. 23018-23027 9 p.

    Research output: Contribution to journalArticlepeer-review

  6. Published

    Gentherapie der zystischen fibrose: Eine analyse der bisherigen klinischen studien

    Coutelle, C. & Bigger, B., 2001, In: Internist. 42, 10, p. 1346-1356 10 p.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Perspectives on gene therapy for cystic fibrosis airway disease

    Bigger, B. & Coutelle, C., 2001, In: BioDrugs. 15, 9, p. 615-634 19 p.

    Research output: Contribution to journalArticlepeer-review

  8. 2000
  9. Published

    Introduction of chloramphenicol resistance into the modified mouse mitochondrial genome: Cloning of unstable sequences by passage through yeast

    Bigger, B., Tolmachov, O., Collombet, J. M. & Coutelle, C., 15 Jan 2000, In: Analytical Biochemistry. 277, 2, p. 236-242 6 p.

    Research output: Contribution to journalArticlepeer-review

  10. 1999
  11. Published

    Tipping the scales in favour of mitochondrial gene therapy

    Bigger, B., Collombet, J. M. & Coutelle, C., Dec 1999, In: Gene Therapy. 6, 12, p. 1909-1910 1 p.

    Research output: Contribution to journalArticlepeer-review

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