Prof Brian Bigger PhD

RecET driven chromosomal gene targeting to generate a RecA deficient Escherichia coli strain for Cre mediated production of minicircle DNA

Tolmachov, O., Palaszewski, I., Bigger, B. & Coutelle, C., 10 Mar 2006, In: BMC Biotechnology. 6, 17.

Research output: Contribution to journal › Article › peer-review

Recommendations on clinical trial design for treatment of Mucopolysaccharidosis Type III

Ghosh, A., Shapiro, E., Rust, S., Delaney, K., Parker, S., Shaywitz, A. J., Morte, A., Bubb, G., Cleary, M., Bo, T., Lavery, C., Bigger, B. & Jones, S., 2017, In: Orphanet Journal of Rare Diseases.

Research output: Contribution to journal › Article › peer-review

Signal One and Two Blockade Are Both Critical for Non-Myeloablative Murine HSCT across a Major Histocompatibility Complex Barrier

Langford-Smith, K. J., Sandiford, Z., Langford-Smith, A., Wilkinson, F. L., Jones, S. A., Wraith, J. E., Wynn, R. F. & Bigger, B. W., 17 Oct 2013, In: PLoS ONE. 8, 10, e77632.

Research output: Contribution to journal › Article › peer-review

Sleep disordered breathing in mucopolysaccharidosis I: a multivariate analysis of patient, therapeutic and metabolic correlators modifying long term clinical outcome.

Pal, A. R., Langereis, E. J., Saif, M. A., Mercer, J., Church, H. J., Tylee, K. L., Wynn, R. F., Wijburg, F. A., Jones, S. A., Bruce, I. A. & Bigger, B. W., 2015, In: Orphanet Journal of Rare Diseases. 10

Research output: Contribution to journal › Article › peer-review

Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients

Griffiths, W. J., Abdel-Khalik, J., Crick, P. J., Ogundare, M., Shackleton, C. H., Tuschl, K., Kwok, M. K., Bigger, B. W., Morris, A. A., Honda, A., Xu, L., Porter, N. A., Björkhem, I., Clayton, P. T. & Wang, Y., 1 May 2017, In: Journal of Steroid Biochemistry and Molecular Biology.

Research output: Contribution to journal › Article › peer-review

Strategies for the Induction of Immune Tolerance to Enzyme Replacement Therapy in Mucopolysaccharidosis Type I

Ghosh, A., Liao, A., O'Leary, C., Mercer, J., Tylee, K., Goenka, A., Holley, R., Jones, S. A. & Bigger, B. W., 14 Jun 2019, In: Molecular Therapy - Methods and Clinical Development. 13, p. 321-333 13 p.

Research output: Contribution to journal › Article › peer-review

Substrate accumulation and extracellular matrix remodelling promote persistent upper airway disease in mucopolysaccharidosis patients on enzyme replacement therapy

Pal, A. R., Mercer, J., Jones, S. A., Bruce, I. A., Bigger, B. W. & Dardis, A. (ed.), 18 Sep 2018, In: PLoS ONE. 13, 9, p. e0203216

Research output: Contribution to journal › Article › peer-review

Successful allogeneic bone marrow transplant for Niemann-Pick disease type C2 is likely to be associated with a severe 'graft versus substrate' effect

Bonney, D. K., O'Meara, A., Shabani, A., Imrie, J., Bigger, B. W., Jones, S., Wraith, J. E. & Wynn, R. F., 2010, In: Journal of Inherited Metabolic Disease. 33, 3, p. S171-S173

Research output: Contribution to journal › Article › peer-review

Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer

Green, D., Eyre, H., Singh, A., Taylor, J., Chu, J., Jeys, L., Sumathi, V. P., Coonar, A., Rassl, D., Babur, M., Forster, D., Alzabin, S., Ponthan, F., McMahon, A., Bigger, B., Reekie, T., Kassiou, M., Williams, K., Dalmay, T., Fraser, W. D. & 1 others, Finegan, K., 13 Jul 2020, In: Oncogene. 39, p. 5553–5569

Research output: Contribution to journal › Article › peer-review

The Bone Marrow Functionally Contributes to Liver Fibrosis

Russo, F. P., Alison, M. R., Bigger, B. W., Amofah, E., Florou, A., Amin, F., Bou-Gharios, G., Jeffery, R., Iredale, J. P. & Forbes, S. J., Jun 2006, In: Gastroenterology. 130, 6, p. 1807-1821 14 p.

Research output: Contribution to journal › Article › peer-review