Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

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Publications

  1. 2006
  2. Published

    The Bone Marrow Functionally Contributes to Liver Fibrosis

    Russo, F. P., Alison, M. R., Bigger, B. W., Amofah, E., Florou, A., Amin, F., Bou-Gharios, G., Jeffery, R., Iredale, J. P. & Forbes, S. J., Jun 2006, In: Gastroenterology. 130, 6, p. 1807-1821 14 p.

    Research output: Contribution to journalArticlepeer-review

  3. Published

    RecET driven chromosomal gene targeting to generate a RecA deficient Escherichia coli strain for Cre mediated production of minicircle DNA

    Tolmachov, O., Palaszewski, I., Bigger, B. & Coutelle, C., 10 Mar 2006, In: BMC Biotechnology. 6, 17.

    Research output: Contribution to journalArticlepeer-review

  4. Published

    Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX

    Bigger, B., Siapati, E. K., Mistry, A., Waddington, S. N., Nivsarkar, M. S., Jacobs, L., Perrett, R., Holder, M. V., Ridler, C., Kemball-Cook, G., Ali, R. R., Forbes, S. J., Coutelle, C., Wright, N., Alison, M., Thrasher, A. J., Bonnet, D. & Themis, M., Jan 2006, In: Gene Therapy. 13, 2, p. 117-126 9 p.

    Research output: Contribution to journalArticlepeer-review

  5. 2005
  6. Published

    Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice

    Themis, M., Waddington, S. N., Schmidt, M., von Kalle, C., Wang, Y., Al-Allaf, F., Gregory, L. G., Nivsarkar, M., Themis, M., Holder, M. V., Buckley, S. M. K., Dighe, N., Ruthe, A. T., Mistry, A., Bigger, B., Rahim, A., Nguyen, T. H., Trono, D., Thrasher, A. J. & Coutelle, C., Oct 2005, In: Molecular Therapy. 12, 4, p. 763-771 8 p.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Comparison of HIV- and EIAV-based vectors on their efficiency in transducing murine and human hematopoietic repopulating cells

    Siapati, E. K., Bigger, B. W., Miskin, J., Chipchase, D., Parsley, K. L., Mitrophanous, K., Themis, M., Thrasher, A. J. & Bonnet, D., Sep 2005, In: Molecular Therapy. 12, 3, p. 537-546 9 p.

    Research output: Contribution to journalArticlepeer-review

  8. Published

    Minimised, CpG-depleted and methylated DNA vectors: Towards perfection in non-viral gene therapy

    Bigger, B. W., Tolmachov, O., Harbottle, R., Coutelle, C. & Schleef, M. (ed.), 2005, DNA-Pharmaceuticals: Formulation and delivery in gene therapy, DNA vaccination and immunotherapy. Cambridge, UK: John Wiley & Sons Ltd

    Research output: Chapter in Book/Report/Conference proceedingChapter

  9. 2004
  10. Published

    Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy

    Waddington, S. N., Nivsarkar, M. S., Mistry, A. R., Buckley, S. M. K., Kemball-Cook, G., Mosley, K. L., Mitrophanous, K., Radcliffe, P., Holder, M. V., Brittan, M., Georgiadis, A., Al-Allaf, F., Bigger, B. W., Gregory, L. G., Terence Cook, H., Ali, R. R., Thrasher, A., Tuddenham, E. G. D., Themis, M. & Coutelle, C., 1 Nov 2004, In: Blood. 104, 9, p. 2714-2721 7 p.

    Research output: Contribution to journalArticlepeer-review

  11. Published

    Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy

    Bigger, B., Gregory, L. G., Waddington, S. N., Holder, M. V., Mitrophanous, K. A., Buckley, S. M. K., Mosley, K. L., Bigger, B. W., Ellard, F. M., Walmsley, L. E., Lawrence, L., Al-Allaf, F., Kingsman, S., Coutelle, C. & Themis, M., Jul 2004, In: Gene Therapy. 11, 14, p. 1117-1125 8 p.

    Research output: Contribution to journalArticlepeer-review

  12. Published

    Development of a Self-assembling Nuclear Targeting Vector System Based on the Tetracycline Repressor Protein

    Vaysse, L., Harbottle, R., Bigger, B., Bergau, A., Tolmachov, O. & Coutelle, C., 13 Feb 2004, In: Journal of Biological Chemistry. 279, 7, p. 5555-5564 9 p.

    Research output: Contribution to journalArticlepeer-review

  13. Published

    Hepatic stem cells: From inside and outside the liver?

    Alison, M. R., Vig, P., Russo, F., Bigger, B. W., Amofah, E., Themis, M. & Forbes, S., Feb 2004, In: Cell Proliferation. 37, 1, p. 1-21 20 p.

    Research output: Contribution to journalArticlepeer-review

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