Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

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Phone: +44 (0) 161 306 0516
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ORCID: 0000-0002-9708-1112
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Publications

61 - 70 out of 87Page size: 10
  1. 2010
  2. Published

    Circadian rhythm and suprachiasmatic nucleus alterations in the mouse model of mucopolysaccharidosis IIIB

    Canal, M. M., Wilkinson, F. L., Cooper, J. D., Ed Wraith, J., Wynn, R. & Bigger, B. W., 19 Jun 2010, In: Behavioural brain research. 209, 2, p. 212-220 8 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.bbr.2010.01.045
  3. Published

    Evaluation of heparin cofactor II-thrombin complex as a biomarker on blood spots from mucopolysaccharidosis I, IIIA and IIIB mice

    Langford-Smith, K., Arasaradnam, M., Wraith, J. E., Wynn, R. & Bigger, B. W., Mar 2010, In: Molecular genetics and metabolism. 99, 3, p. 269-274 5 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.ymgme.2009.10.175
  4. Published

    Immune activation or immunomodulation in the brains of MPS IIIB mice? Commentary on "innate and adaptive immune activation in the brain of MPS IIIB mouse model"

    Archer, L. D., Langford, K., Bigger, B. & Fildes, J. E., 1 Feb 2010, In: Journal of Neuroscience Research. 88, 2, p. 233

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1002/jnr.22211
  5. Published

    Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease

    Malinowska, M., Wilkinson, F. L., Langford-Smith, K. J., Langford-Smith, A., Brown, J. R., Crawford, B. E., Vanier, M. T., Grynkiewicz, G., Wynn, R. F., Ed Wraith, J., Wegrzyn, G. & Bigger, B. W., 2010, In: PLoS ONE. 5, 12, e14192.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1371/journal.pone.0014192
  6. Published

    Successful allogeneic bone marrow transplant for Niemann-Pick disease type C2 is likely to be associated with a severe 'graft versus substrate' effect

    Bonney, D. K., O'Meara, A., Shabani, A., Imrie, J., Bigger, B. W., Jones, S., Wraith, J. E. & Wynn, R. F., 2010, In: Journal of Inherited Metabolic Disease. 33, 3, p. S171-S173

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1007/s10545-010-9060-3
  7. 2009
  8. Published

    Genistein reduces lysosomal storage in peripheral tissues of mucopolysaccharide IIIB mice

    Malinowska, M., Wilkinson, F. L., Bennett, W., Langford-Smith, K. J., O'Leary, H. A., Jakobkiewicz-Banecka, J., Wynn, R., Wraith, J. E., Wegrzyn, G. & Bigger, B. W., Nov 2009, In: Molecular genetics and metabolism. 98, 3, p. 235-242 7 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.ymgme.2009.06.013
  9. Published

    Cellular therapy of lysosomal storage disorders: Current status and future prospects

    Wynn, R. F., Stubbs, M., Ozyilmaz, N., Wraith, J. E. & Bigger, B., Aug 2009, In: Current Pediatric Reviews. 5, 3, p. 147-159 12 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.2174/157339609789007187
  10. Published

    Improved Metabolic Correction in Patients with Lysosomal Storage Disease Treated with Hematopoietic Stem Cell Transplant Compared with Enzyme Replacement Therapy

    Wynn, R. F., Wraith, J. E., Mercer, J., O'Meara, A., Tylee, K., Thornley, M., Church, H. J. & Bigger, B. W., Apr 2009, In: Journal Of Pediatrics. 154, 4, p. 609-611 2 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.jpeds.2008.11.005
  11. 2007
  12. Published

    Xenogenic transfer of isolated murine mitochondria into human ρ0 cells can improve respiratory function

    Katrangi, E., D'Souza, G., Boddapati, S. V., Kulawiec, M., Singh, K. K., Bigger, B. & Weissig, V., 1 Dec 2007, In: Rejuvenation Research. 10, 4, p. 561-570 9 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1089/rej.2007.0575
  13. Published

    Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells

    Siapati, E. K., Bigger, B. W., Kashofer, K., Themis, M., Thrasher, A. J. & Bonnet, D., Apr 2007, In: European journal of haematology. 78, 4, p. 303-313 10 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1111/j.1600-0609.2006.00813.x
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Research Explorer downloads

106
Recommendations on clinical trial design for treatment of Mucopolysaccharidosis Type III

Research output: Contribution to journal › Article › peer-review

45
Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease

Research output: Contribution to journal › Article › peer-review

18
Delivering Hematopoietic Stem Cell Gene Therapy Treatments for Neurological Lysosomal Diseases.

Research output: Contribution to journal › Review article › peer-review