Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

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Publications

  1. 2014
  2. Published

    An investigation of the middle and late behavioural phenotypes of Mucopolysaccharidosis Type-III.

    Cross, E. M., Grant, S., Jones, S., Bigger, B. W., Wraith, J. E., Mahon, L. V., Lomax, M. & Hare, D. J., 2014, In: Journal of neurodevelopmental disorders. 6, 1

    Research output: Contribution to journalArticlepeer-review

  3. Published

    Novel approaches and mechanisms in hematopoietic stem cell gene therapy

    Bigger, B. W. & Wynn, R. F., 2014, In: Discovery Medicine. 17, 94

    Research output: Contribution to journalArticlepeer-review

  4. 2013
  5. Published

    Signal One and Two Blockade Are Both Critical for Non-Myeloablative Murine HSCT across a Major Histocompatibility Complex Barrier

    Langford-Smith, K. J., Sandiford, Z., Langford-Smith, A., Wilkinson, F. L., Jones, S. A., Wraith, J. E., Wynn, R. F. & Bigger, B. W., 17 Oct 2013, In: PLoS ONE. 8, 10, e77632.

    Research output: Contribution to journalArticlepeer-review

  6. Published

    Myeloid/Microglial driven autologous hematopoietic stem cell gene therapy corrects a neuronopathic lysosomal disease

    Sergijenko, A., Langford-Smith, A., Liao, A. Y., Pickford, C. E., McDermott, J., Nowinski, G., Langford-Smith, K. J., Merry, C. L., Jones, S. A., Wraith, J. E., Wynn, R. F., Wilkinson, F. L. & Bigger, B. W., Oct 2013, In: Molecular Therapy. 21, 10, p. 1938-1949 11 p.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice

    Denes, A., Wilkinson, F., Bigger, B., Chu, M., Rothwell, N. J. & Allan, S. M., Jul 2013, In: DMM Disease Models and Mechanisms. 6, 4, p. 1043-1048 5 p.

    Research output: Contribution to journalArticlepeer-review

  8. Published

    Analytical strategies for characterization of oxysterol lipidomes: Liver X receptor ligands in plasma

    Griffiths, W. J., Crick, P. J., Wang, Y., Ogundare, M., Tuschl, K., Morris, A. A., Bigger, B. W., Clayton, P. T. & Wang, Y., Jun 2013, In: Free Radical Biology and Medicine. 59, p. 69-84 15 p.

    Research output: Contribution to journalArticlepeer-review

  9. Published

    Busulfan conditioning enhances engraftment of hematopoietic donor-derived cells in the brain compared with irradiation

    Wilkinson, F. L., Sergijenko, A., Langford-Smith, K. J., Malinowska, M., Wynn, R. F. & Bigger, B. W., Apr 2013, In: Molecular Therapy. 21, 4, p. 868-876 8 p.

    Research output: Contribution to journalArticlepeer-review

  10. Published

    Characterisation of the T cell and dendritic cell repertoire in a murine model of mucopolysaccharidosis i (MPS I)

    Archer, L. D., Langford-Smith, K. J., Critchley, W. R., Bigger, B. W. & Fildes, J. E., Mar 2013, In: Journal of Inherited Metabolic Disease. 36, 2, p. 257-262 5 p.

    Research output: Contribution to journalArticlepeer-review

  11. Published

    Parental social support, coping strategies, resilience factors, stress, anxiety and depression levels in parents of children with MPS III (Sanfilippo syndrome) or children with intellectual disabilities (ID)

    Grant, S., Cross, E., Wraith, J. E., Jones, S., Mahon, L., Lomax, M., Bigger, B. & Hare, D., Mar 2013, In: Journal of Inherited Metabolic Disease. 36, 2, p. 281-291 10 p.

    Research output: Contribution to journalArticlepeer-review

  12. Published

    Plasma and urinary levels of dermatan sulfate and heparan sulfate derived disaccharides after long-term enzyme replacement therapy (ERT) in MPS I: correlation with the timing of ERT and with total urinary excretion of glycosaminoglycans

    De Ru, M. H., Van Der Tol, L., Van Vlies, N., Bigger, B. W., Hollak, C. E. M., Ijlst, L., Kulik, W., Van Lenthe, H., Saif, M., Wagemans, T., Van Der Wal, W. M., Wanders, R. J. & Wijburg, F. A., Mar 2013, In: Journal of inherited metabolic disorders. 36, 2, p. 247-255 8 p.

    Research output: Contribution to journalArticlepeer-review

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