Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

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Phone: +44 (0) 161 306 0516
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ORCID: 0000-0002-9708-1112
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Publications

21 - 30 out of 87Page size: 10
  1. 2018
  2. Published

    Identification Of Unusual Oxysterols And Bile acids With 7-Oxo Or 3β,5α,6β-Trihydroxy Functions In Human Plasma By Charge-Tagging Mass Spectrometry With Multistage Fragmentation

    Griffiths, W. J., Gilmore, I., Yutuc, E., Abdel-Khalik, J., Crick, P. J., Hearn, T., Dickson, A., Bigger, B. W., Goenka, A., Ghosh, A., Jones, S. A. & Wang, Y., 2018, In: Journal of Lipid Research. 59

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1194/jlr.D083246
  3. Published

    The role of innate immunity in mucopolysaccharide diseases

    Parker, H. & Bigger, B. W., 2018, In: Journal of neurochemistry.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1111/jnc.14632
  4. 2017
  5. Published

    Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients

    Griffiths, W. J., Abdel-Khalik, J., Crick, P. J., Ogundare, M., Shackleton, C. H., Tuschl, K., Kwok, M. K., Bigger, B. W., Morris, A. A., Honda, A., Xu, L., Porter, N. A., Björkhem, I., Clayton, P. T. & Wang, Y., 1 May 2017, In: Journal of Steroid Biochemistry and Molecular Biology.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.jsbmb.2016.03.018
  6. Published

    Identification of Age-Dependent Motor and Neuropsychological Behavioural Abnormalities in a Mouse Model of Mucopolysaccharidosis Type II

    Gleitz, H., O'Leary, C., Holley, R. & Bigger, B., 16 Feb 2017, In: PLoS ONE.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1371/journal.pone.0172435
  7. Published

    Mucopolysaccharidosis type IIIA storage substrate drives an innate immune neuro-inflammatory response

    Bigger, B., Boutin, H., Wilkinson, F., Holley, R., Brough, D., Pinteaux, E. & Parker, H., 2017, p. S27-S28.

    Research output: Contribution to conference › Abstract › peer-review

    DOI: 10.1016/j.ymgme.2016.11.042
  8. Published

    Recommendations on clinical trial design for treatment of Mucopolysaccharidosis Type III

    Ghosh, A., Shapiro, E., Rust, S., Delaney, K., Parker, S., Shaywitz, A. J., Morte, A., Bubb, G., Cleary, M., Bo, T., Lavery, C., Bigger, B. & Jones, S., 2017, In: Orphanet Journal of Rare Diseases.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1186/s13023-017-0675-4
  9. 2016
  10. Published

    Enzyme replacement therapy prior to haematopoietic stem cell transplantation in Mucopolysaccharidosis Type I: 10 year combined experience of 2 centres

    Ghosh, A., Miller, W., Orchard, P. J., Jones, S. A., Mercer, J., Church, H. J., Tylee, K., Lund, T., Bigger, B. W., Tolar, J. & Wynn, R. F., 1 Mar 2016, In: Molecular genetics and metabolism. 117, 3, p. 373-377 5 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.ymgme.2016.01.011
  11. Published

    Hematopoietic stem cell transplant for the mucopolysaccharidoses

    Lum, S. H., Jones, S. A., Ghosh, A., Bigger, B. W. & Wynn, R. F., 24 Feb 2016, In: Expert Opinion on Orphan Drugs. 4, 4, p. 379-393 15 p.

    Research output: Contribution to journal › Review article › peer-review

    DOI: 10.1517/21678707.2016.1147948
  12. Published

    The impact of the immune system on the safety and efficiency of enzyme replacement therapy in lysosomal storage disorders

    Broomfield, A., Jones, S. A., Hughes, S. M. & Bigger, B. W., 16 Feb 2016, In: Journal of Inherited Metabolic Disease. 39, 4, p. 499-512 14 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1007/s10545-016-9917-1
  13. 2015
  14. Published

    In vivo T-cell depletion using alemtuzumab in family and unrelated donor transplantation for pediatric non-malignant disease achieves engraftment with low incidence of graft vs. host disease.

    Saif, M. A., Borrill, R., Bigger, B. W., Lee, H., Logan, A., Poulton, K., Hughes, S., Turner, A. J., Bonney, D. K. & Wynn, R. F., Mar 2015, In: Pediatric transplantation. 19, 2

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1111/petr.12416
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Research Explorer downloads

106
Recommendations on clinical trial design for treatment of Mucopolysaccharidosis Type III

Research output: Contribution to journal › Article › peer-review

45
Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease

Research output: Contribution to journal › Article › peer-review

18
Delivering Hematopoietic Stem Cell Gene Therapy Treatments for Neurological Lysosomal Diseases.

Research output: Contribution to journal › Review article › peer-review