Prof Brian Bigger PhD

Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders

Griffiths, W. J., Yutuc, E., Abdel-Khalik, J., Crick, P. J., Hearn, T., Dickson, A., Bigger, B. W., Hoi-Yee Wu, T., Goenka, A., Ghosh, A., Jones, S. A., Covey, D. F., Ory, D. S. & Wang, Y., 2019, In: Free Radical Biology and Medicine.

Research output: Contribution to journal › Article › peer-review

Non-myeloablative busulfan chimeric mouse models are less pro-inflammatory than head-shielded irradiation for studying immune cell interactions in brain tumours

Youshani, A. S., Rowlston, S., O'Leary, C., Forte, G., Parker, H., Liao, A., Telfer, B., Williams, K., Kamaly-Asl, I. D. & Bigger, B. W., 2019, In: Journal of Neuroinflammation. 16, 1, 25.

Research output: Contribution to journal › Article › peer-review

Substrate accumulation and extracellular matrix remodelling promote persistent upper airway disease in mucopolysaccharidosis patients on enzyme replacement therapy

Pal, A. R., Mercer, J., Jones, S. A., Bruce, I. A., Bigger, B. W. & Dardis, A. (ed.), 18 Sep 2018, In: PLoS ONE. 13, 9, p. e0203216

Research output: Contribution to journal › Article › peer-review

Brain‐targeted stem cell gene therapy corrects mucopolysaccharidosis type II via multiple mechanisms

Gleitz, H. F., Liao, A. Y., Cook, J. R., Rowlston, S. F., Forte, G. M., D'souza, Z., O'leary, C., Holley, R. J. & Bigger, B. W., 1 Jul 2018, In: EMBO Molecular Medicine . 10, 7, p. e8730

Research output: Contribution to journal › Article › peer-review

A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency

Tordo, J., O'Leary, C., Antunes, A. S. L. M., Palomar, N., Aldrin-Kirk, P., Basche, M., Bennett, A., D'Souza, Z., Gleitz, H., Godwin, A., Holley, R., Parker, H., Liao, A., Rouse, P., Youshani, A., Dridi, L., Martins, C., Levade, T., Stacey, K., Davis, D. M. & 11 others, Dyer, A., Clement, N., Bjorklund, T., Ali, R. R., Agbandje-McKenna, M., Rahim, A., Pshezhetsky, A. V., Waddington, S. N., Linden, R. M., Bigger, B. & Henckaerts, E., 16 May 2018, In: Brain. 141, 7, p. 2014-2031 18 p.

Research output: Contribution to journal › Article › peer-review

High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma

Yu, K. K. H., Taylor, J. T., Pathmanaban, O. N., Youshani, A. S., Beyit, D., Dutko-Gwozdz, J., Benson, R., Griffiths, G., Peers, I., Cueppens, P., Telfer, B. A., Williams, K. J., McBain, C., Kamaly-Asl, I. D. & Bigger, B. W., 2 Mar 2018, In: PLoS ONE. 13, 3, e0193694.

Research output: Contribution to journal › Article › peer-review

Interleukin-1 plays a central role in behaviour abnormalities in mucopolysaccharidosis type III (MPS HI)

Bigger, B. W., Holley, R., Ellison, S., O'Leary, C., Pinteaux, E., Boutin, H. & Parker, H., Feb 2018, In: Molecular genetics and metabolism. 123, 2, p. S24-S25

Research output: Contribution to journal › Meeting Abstract › peer-review

Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy

Holley, R. J., Ellison, S. M., Fil, D., O'Leary, C., McDermott, J., Senthivel, N., Langford-Smith, A. W. W., Wilkinson, F. L., D'Souza, Z., Parker, H., Liao, A., Rowlston, S., Gleitz, H. F. E., Kan, S. H., Dickson, P. I. & Bigger, B. W., 1 Jan 2018, In: Brain. 141, 1, p. 99-116 18 p.

Research output: Contribution to journal › Article › peer-review

Anatomical changes and pathophysiology of the brain in mucopolysaccharidosis disorders

Bigger, B. W., Begley, D. J., Virgintino, D. & Pshezhetsky, A. V., 2018, In: Molecular genetics and metabolism.

Research output: Contribution to journal › Article › peer-review

Delivering Hematopoietic Stem Cell Gene Therapy Treatments for Neurological Lysosomal Diseases.

Holley, R., Wood, S. & Bigger, B., 2018, In: ACS Chemical Neuroscience.

Research output: Contribution to journal › Review article › peer-review