Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

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Publications

  1. 2020
  2. Published

    Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer

    Green, D., Eyre, H., Singh, A., Taylor, J., Chu, J., Jeys, L., Sumathi, V. P., Coonar, A., Rassl, D., Babur, M., Forster, D., Alzabin, S., Ponthan, F., McMahon, A., Bigger, B., Reekie, T., Kassiou, M., Williams, K., Dalmay, T., Fraser, W. D. & 1 others, Finegan, K., 13 Jul 2020, In: Oncogene. 39, p. 5553–5569

    Research output: Contribution to journalArticlepeer-review

  3. Published

    Actinomycin D Downregulates Sox2 and Improves Survival in Preclinical Models of Recurrent Glioblastoma

    Taylor, J. T., Ellison, S., Pandele, A., Wood, S., Nathan, E., Forte, G., Parker, H., Zindy, E., Elvin, M., Dickson, A., Williams, K. J., Karabatsou, K., McCabe, M., McBain, C. & Bigger, B. W., 30 Mar 2020, In: Neuro-Oncology. 22, 9, p. 1289-1301 13 p.

    Research output: Contribution to journalArticlepeer-review

  4. Published

    Haematopoietic stem cell gene therapy with IL-1Ra rescues cognitive loss in mucopolysaccharidosis IIIA

    Parker, H., Ellison, S. M., Holley, R. J., O'Leary, C., Liao, A., Asadi, J., Glover, E., Ghosh, A., Jones, S., Wilkinson, F. L., Brough, D., Pinteaux, E., Boutin, H. & Bigger, B. W., 6 Mar 2020, In: EMBO Molecular Medicine. 12, 3, e11185.

    Research output: Contribution to journalArticlepeer-review

  5. 2019
  6. Published

    Post-transplant laronidase augmentation for children with Hurler syndrome: biochemical outcomes

    Lund, T. C., Miller, W. P., Liao, A. Y., Tolar, J., Shanley, R., Pasquali, M., Sando, N., Bigger, B. W., Polgreen, L. E. & Orchard, P. J., 1 Dec 2019, In: Scientific Reports. 9, 1, 14105.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Hampering brain tumor proliferation and migration using peptide nanofiber:siPLK1/MMP2 complexes

    Mazza, M., Ahmad, H., Hadjidemetriou, M., Agliardi, G., Pathmanaban, O. N., King, A. T., Bigger, B. W., Vranic, S. & Kostarelos, K., Dec 2019, In: nanomedicine. 14, 24, p. 3127-3142 16 p.

    Research output: Contribution to journalArticlepeer-review

  8. Published

    An Improved Adeno-Associated Virus Vector for Neurological Correction of the Mouse Model of Mucopolysaccharidosis IIIA

    Gray, A. L., O'Leary, C., Liao, A., Agúndez, L., Youshani, A. S., Gleitz, H. F., Parker, H., Taylor, J. T., Danos, O., Hocquemiller, M., Palomar, N., Linden, R. M., Henckaerts, E., Holley, R. J. & Bigger, B. W., 17 Sep 2019, In: Human Gene Therapy. 30, 9, p. 1052-1066 15 p.

    Research output: Contribution to journalArticlepeer-review

  9. Published

    Pre-clinical Safety and Efficacy of Lentiviral Vector-Mediated Ex Vivo Stem Cell Gene Therapy for the Treatment of Mucopolysaccharidosis IIIA

    Ellison, S. M., Liao, A., Wood, S., Taylor, J., Youshani, A. S., Rowlston, S., Parker, H., Armant, M., Biffi, A., Chan, L., Farzaneh, F., Wynn, R., Jones, S. A., Heal, P., Gaspar, H. B. & Bigger, B. W., 14 Jun 2019, In: Molecular Therapy - Methods and Clinical Development. 13, p. 399-413 15 p.

    Research output: Contribution to journalArticlepeer-review

  10. Published

    Strategies for the Induction of Immune Tolerance to Enzyme Replacement Therapy in Mucopolysaccharidosis Type I

    Ghosh, A., Liao, A., O'Leary, C., Mercer, J., Tylee, K., Goenka, A., Holley, R., Jones, S. A. & Bigger, B. W., 14 Jun 2019, In: Molecular Therapy - Methods and Clinical Development. 13, p. 321-333 13 p.

    Research output: Contribution to journalArticlepeer-review

  11. Published

    Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia

    Al-Allaf, F. A., Abduljaleel, Z., Athar, M., Taher, M. M., Khan, W., Mehmet, H., Colakogullari, M., Apostolidou, S., Bigger, B., Waddington, S., Coutelle, C., Themis, M., Al-Ahdal, M. N., Al-Mohanna, F. A., Al-Hassnan, Z. N. & Bouazzaoui, A., Mar 2019, In: Non-coding RNA research. 4, 1, p. 1-14 14 p.

    Research output: Contribution to journalArticlepeer-review

  12. Published

    A nonmyeloablative chimeric mouse model accurately defines microglia and macrophage contribution in glioma

    Yu, K., Youshani, A. S., Wilkinson, F. L., O'Leary, C., Cook, P., Laaniste, L., Liao, A., Mosses, D., Waugh, C., Shorrock, H., Pathmanaban, O., Macdonald, A., Kamaly-Asl, I., Roncaroli, F. & Bigger, B. W., 1 Feb 2019, In: Neuropathology and Applied Neurobiology. 45, 2, p. 119-140 22 p.

    Research output: Contribution to journalArticlepeer-review

  13. Published

    Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders

    Griffiths, W. J., Yutuc, E., Abdel-Khalik, J., Crick, P. J., Hearn, T., Dickson, A., Bigger, B. W., Hoi-Yee Wu, T., Goenka, A., Ghosh, A., Jones, S. A., Covey, D. F., Ory, D. S. & Wang, Y., 2019, In: Free Radical Biology and Medicine.

    Research output: Contribution to journalArticlepeer-review

  14. Published

    Non-myeloablative busulfan chimeric mouse models are less pro-inflammatory than head-shielded irradiation for studying immune cell interactions in brain tumours

    Youshani, A. S., Rowlston, S., O'Leary, C., Forte, G., Parker, H., Liao, A., Telfer, B., Williams, K., Kamaly-Asl, I. D. & Bigger, B. W., 2019, In: Journal of Neuroinflammation. 16, 1, 25.

    Research output: Contribution to journalArticlepeer-review

  15. 2018
  16. Published

    Substrate accumulation and extracellular matrix remodelling promote persistent upper airway disease in mucopolysaccharidosis patients on enzyme replacement therapy

    Pal, A. R., Mercer, J., Jones, S. A., Bruce, I. A., Bigger, B. W. & Dardis, A. (ed.), 18 Sep 2018, In: PLoS ONE. 13, 9, p. e0203216

    Research output: Contribution to journalArticlepeer-review

  17. Published

    Brain‐targeted stem cell gene therapy corrects mucopolysaccharidosis type II via multiple mechanisms

    Gleitz, H. F., Liao, A. Y., Cook, J. R., Rowlston, S. F., Forte, G. M., D'souza, Z., O'leary, C., Holley, R. J. & Bigger, B. W., 1 Jul 2018, In: EMBO Molecular Medicine . 10, 7, p. e8730

    Research output: Contribution to journalArticlepeer-review

  18. Published

    A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency

    Tordo, J., O'Leary, C., Antunes, A. S. L. M., Palomar, N., Aldrin-Kirk, P., Basche, M., Bennett, A., D'Souza, Z., Gleitz, H., Godwin, A., Holley, R., Parker, H., Liao, A., Rouse, P., Youshani, A., Dridi, L., Martins, C., Levade, T., Stacey, K., Davis, D. M. & 11 others, Dyer, A., Clement, N., Bjorklund, T., Ali, R. R., Agbandje-McKenna, M., Rahim, A., Pshezhetsky, A. V., Waddington, S. N., Linden, R. M., Bigger, B. & Henckaerts, E., 16 May 2018, In: Brain. 141, 7, p. 2014-2031 18 p.

    Research output: Contribution to journalArticlepeer-review

  19. Published

    High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma

    Yu, K. K. H., Taylor, J. T., Pathmanaban, O. N., Youshani, A. S., Beyit, D., Dutko-Gwozdz, J., Benson, R., Griffiths, G., Peers, I., Cueppens, P., Telfer, B. A., Williams, K. J., McBain, C., Kamaly-Asl, I. D. & Bigger, B. W., 2 Mar 2018, In: PLoS ONE. 13, 3, e0193694.

    Research output: Contribution to journalArticlepeer-review

  20. Published

    Interleukin-1 plays a central role in behaviour abnormalities in mucopolysaccharidosis type III (MPS HI)

    Bigger, B. W., Holley, R., Ellison, S., O'Leary, C., Pinteaux, E., Boutin, H. & Parker, H., Feb 2018, In: Molecular genetics and metabolism. 123, 2, p. S24-S25

    Research output: Contribution to journalMeeting Abstractpeer-review

  21. Published

    Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy

    Holley, R. J., Ellison, S. M., Fil, D., O'Leary, C., McDermott, J., Senthivel, N., Langford-Smith, A. W. W., Wilkinson, F. L., D'Souza, Z., Parker, H., Liao, A., Rowlston, S., Gleitz, H. F. E., Kan, S. H., Dickson, P. I. & Bigger, B. W., 1 Jan 2018, In: Brain. 141, 1, p. 99-116 18 p.

    Research output: Contribution to journalArticlepeer-review

  22. Published

    Anatomical changes and pathophysiology of the brain in mucopolysaccharidosis disorders

    Bigger, B. W., Begley, D. J., Virgintino, D. & Pshezhetsky, A. V., 2018, In: Molecular genetics and metabolism.

    Research output: Contribution to journalArticlepeer-review

  23. Published

    Delivering Hematopoietic Stem Cell Gene Therapy Treatments for Neurological Lysosomal Diseases.

    Holley, R., Wood, S. & Bigger, B., 2018, In: ACS Chemical Neuroscience.

    Research output: Contribution to journalReview articlepeer-review

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