Prof Brian Bigger PhD

Substrate accumulation and extracellular matrix remodelling promote persistent upper airway disease in mucopolysaccharidosis patients on enzyme replacement therapy

Pal, A. R., Mercer, J., Jones, S. A., Bruce, I. A., Bigger, B. W. & Dardis, A. (ed.), 18 Sep 2018, In: PLoS ONE. 13, 9, p. e0203216

Research output: Contribution to journal › Article › peer-review

Successful allogeneic bone marrow transplant for Niemann-Pick disease type C2 is likely to be associated with a severe 'graft versus substrate' effect

Bonney, D. K., O'Meara, A., Shabani, A., Imrie, J., Bigger, B. W., Jones, S., Wraith, J. E. & Wynn, R. F., 2010, In: Journal of Inherited Metabolic Disease. 33, 3, p. S171-S173

Research output: Contribution to journal › Article › peer-review

Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer

Green, D., Eyre, H., Singh, A., Taylor, J., Chu, J., Jeys, L., Sumathi, V. P., Coonar, A., Rassl, D., Babur, M., Forster, D., Alzabin, S., Ponthan, F., McMahon, A., Bigger, B., Reekie, T., Kassiou, M., Williams, K., Dalmay, T., Fraser, W. D. & 1 others, Finegan, K., 13 Jul 2020, In: Oncogene. 39, p. 5553–5569

Research output: Contribution to journal › Article › peer-review

The Bone Marrow Functionally Contributes to Liver Fibrosis

Russo, F. P., Alison, M. R., Bigger, B. W., Amofah, E., Florou, A., Amin, F., Bou-Gharios, G., Jeffery, R., Iredale, J. P. & Forbes, S. J., Jun 2006, In: Gastroenterology. 130, 6, p. 1807-1821 14 p.

Research output: Contribution to journal › Article › peer-review

The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis

Nowrouzi, A., Cheung, W. T., Li, T., Zhang, X., Arens, A., Paruzynski, A., Waddington, S. N., Osejindu, E., Reja, S., Von Kalle, C., Wang, Y., Al-Allaf, F., Gregory, L., Themes, M., Holder, M., Dighe, N., Ruthe, A., Buckley, S. M. K., Bigger, B., Montini, E. & 7 others, Thrasher, A. J., Andrews, R., Roberts, T. P., Newbold, R. F., Coutelle, C., Schmidt, M. & Themis, M., Feb 2013, In: Molecular Therapy. 21, 2, p. 324-337 13 p.

Research output: Contribution to journal › Article › peer-review

The impact of the immune system on the safety and efficiency of enzyme replacement therapy in lysosomal storage disorders

Broomfield, A., Jones, S. A., Hughes, S. M. & Bigger, B. W., 16 Feb 2016, In: Journal of Inherited Metabolic Disease. 39, 4, p. 499-512 14 p.

Research output: Contribution to journal › Article › peer-review

The role of antibodies in enzyme treatments and therapeutic strategies.

Bigger, B. W., Saif, M. & Linthorst, G. E., Mar 2015, In: Best practice & research. Clinical endocrinology & metabolism. 29, 2

Research output: Contribution to journal › Article › peer-review

The role of innate immunity in mucopolysaccharide diseases

Parker, H. & Bigger, B. W., 2018, In: Journal of neurochemistry.

Research output: Contribution to journal › Article › peer-review

Tipping the scales in favour of mitochondrial gene therapy

Bigger, B., Collombet, J. M. & Coutelle, C., Dec 1999, In: Gene Therapy. 6, 12, p. 1909-1910 1 p.

Research output: Contribution to journal › Article › peer-review

Trial and error: How the unclonable human mitochondrial genome was cloned in yeast

Bigger, B. W., Liao, A. Y., Sergijenko, A. & Coutelle, C., Nov 2011, In: Pharmaceutical Research. 28, 11, p. 2863-2870 7 p.

Research output: Contribution to journal › Article › peer-review