Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

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Publications

  1. Article › Research › Peer-reviewed
  2. Published

    A nonmyeloablative chimeric mouse model accurately defines microglia and macrophage contribution in glioma

    Yu, K., Youshani, A. S., Wilkinson, F. L., O'Leary, C., Cook, P., Laaniste, L., Liao, A., Mosses, D., Waugh, C., Shorrock, H., Pathmanaban, O., Macdonald, A., Kamaly-Asl, I., Roncaroli, F. & Bigger, B. W., 1 Feb 2019, In: Neuropathology and Applied Neurobiology. 45, 2, p. 119-140 22 p.

    Research output: Contribution to journalArticlepeer-review

  3. Published

    A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency

    Tordo, J., O'Leary, C., Antunes, A. S. L. M., Palomar, N., Aldrin-Kirk, P., Basche, M., Bennett, A., D'Souza, Z., Gleitz, H., Godwin, A., Holley, R., Parker, H., Liao, A., Rouse, P., Youshani, A., Dridi, L., Martins, C., Levade, T., Stacey, K., Davis, D. M. & 11 others, Dyer, A., Clement, N., Bjorklund, T., Ali, R. R., Agbandje-McKenna, M., Rahim, A., Pshezhetsky, A. V., Waddington, S. N., Linden, R. M., Bigger, B. & Henckaerts, E., 16 May 2018, In: Brain. 141, 7, p. 2014-2031 18 p.

    Research output: Contribution to journalArticlepeer-review

  4. Published

    Actigraphic investigation of circadian rhythm functioning and activity levels in children with mucopolysaccharidosis type III (Sanfilippo syndrome).

    Mumford, R. A., Mahon, L. V., Jones, S., Bigger, B., Canal, M. & Hare, D. J., 2015, In: Journal of neurodevelopmental disorders. 7, 1

    Research output: Contribution to journalArticlepeer-review

  5. E-pub ahead of print

    Actinomycin D Downregulates Sox2 and Improves Survival in Preclinical Models of Recurrent Glioblastoma

    Taylor, J. T., Ellison, S., Pandele, A., Wood, S., Nathan, E., Forte, G., Parker, H., Zindy, E., Elvin, M., Dickson, A., Williams, K. J., Karabatsou, K., McCabe, M., McBain, C. & Bigger, B. W., 30 Mar 2020, In: Neuro-Oncology.

    Research output: Contribution to journalArticlepeer-review

  6. Published

    An araC-controlled Bacterial cre Expression System to Produce DNA Minicircle Vectors for Nuclear and Mitochondrial Gene Therapy

    Bigger, B. W., Tolmachov, O., Collombet, J. M., Fragkos, M., Palaszewski, I. & Coutelle, C., 22 Jun 2001, In: Journal of Biological Chemistry. 276, 25, p. 23018-23027 9 p.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    An Improved Adeno-Associated Virus Vector for Neurological Correction of the Mouse Model of Mucopolysaccharidosis IIIA

    Gray, A. L., O'Leary, C., Liao, A., Agúndez, L., Youshani, A. S., Gleitz, H. F., Parker, H., Taylor, J. T., Danos, O., Hocquemiller, M., Palomar, N., Linden, R. M., Henckaerts, E., Holley, R. J. & Bigger, B. W., 17 Sep 2019, In: Human Gene Therapy. 30, 9, p. 1052-1066 15 p.

    Research output: Contribution to journalArticlepeer-review

  8. Published

    An investigation of the middle and late behavioural phenotypes of Mucopolysaccharidosis Type-III.

    Cross, E. M., Grant, S., Jones, S., Bigger, B. W., Wraith, J. E., Mahon, L. V., Lomax, M. & Hare, D. J., 2014, In: Journal of neurodevelopmental disorders. 6, 1

    Research output: Contribution to journalArticlepeer-review

  9. Published

    Analytical strategies for characterization of oxysterol lipidomes: Liver X receptor ligands in plasma

    Griffiths, W. J., Crick, P. J., Wang, Y., Ogundare, M., Tuschl, K., Morris, A. A., Bigger, B. W., Clayton, P. T. & Wang, Y., Jun 2013, In: Free Radical Biology and Medicine. 59, p. 69-84 15 p.

    Research output: Contribution to journalArticlepeer-review

  10. Published

    Anatomical changes and pathophysiology of the brain in mucopolysaccharidosis disorders

    Bigger, B. W., Begley, D. J., Virgintino, D. & Pshezhetsky, A. V., 2018, In: Molecular genetics and metabolism.

    Research output: Contribution to journalArticlepeer-review

  11. Published

    Assessment of sleep in children with mucopolysaccharidosis type III

    Mahon, L. V., Lomax, M., Grant, S., Cross, E., Hare, D. J., Wraith, J. E., Jones, S., Bigger, B., Langford-Smith, K. & Canal, M., 4 Feb 2014, In: PLoS ONE. 9, 2, e84128.

    Research output: Contribution to journalArticlepeer-review

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