Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

Full contact details
View graph of relations

Publications

  1. Published

    Identification Of Unusual Oxysterols And Bile acids With 7-Oxo Or 3β,5α,6β-Trihydroxy Functions In Human Plasma By Charge-Tagging Mass Spectrometry With Multistage Fragmentation

    Griffiths, W. J., Gilmore, I., Yutuc, E., Abdel-Khalik, J., Crick, P. J., Hearn, T., Dickson, A., Bigger, B. W., Goenka, A., Ghosh, A., Jones, S. A. & Wang, Y., 2018, In: Journal of Lipid Research. 59

    Research output: Contribution to journalArticlepeer-review

  2. Published

    Immune activation or immunomodulation in the brains of MPS IIIB mice? Commentary on "innate and adaptive immune activation in the brain of MPS IIIB mouse model"

    Archer, L. D., Langford, K., Bigger, B. & Fildes, J. E., 1 Feb 2010, In: Journal of Neuroscience Research. 88, 2, p. 233

    Research output: Contribution to journalArticlepeer-review

  3. Published

    Improved Metabolic Correction in Patients with Lysosomal Storage Disease Treated with Hematopoietic Stem Cell Transplant Compared with Enzyme Replacement Therapy

    Wynn, R. F., Wraith, J. E., Mercer, J., O'Meara, A., Tylee, K., Thornley, M., Church, H. J. & Bigger, B. W., Apr 2009, In: Journal Of Pediatrics. 154, 4, p. 609-611 2 p.

    Research output: Contribution to journalArticlepeer-review

  4. Published

    In vivo T-cell depletion using alemtuzumab in family and unrelated donor transplantation for pediatric non-malignant disease achieves engraftment with low incidence of graft vs. host disease.

    Saif, M. A., Borrill, R., Bigger, B. W., Lee, H., Logan, A., Poulton, K., Hughes, S., Turner, A. J., Bonney, D. K. & Wynn, R. F., Mar 2015, In: Pediatric transplantation. 19, 2

    Research output: Contribution to journalArticlepeer-review

  5. Published

    Interleukin-1 plays a central role in behaviour abnormalities in mucopolysaccharidosis type III (MPS HI)

    Bigger, B. W., Holley, R., Ellison, S., O'Leary, C., Pinteaux, E., Boutin, H. & Parker, H., Feb 2018, In: Molecular genetics and metabolism. 123, 2, p. S24-S25

    Research output: Contribution to journalMeeting Abstractpeer-review

  6. Published

    Introduction of chloramphenicol resistance into the modified mouse mitochondrial genome: Cloning of unstable sequences by passage through yeast

    Bigger, B., Tolmachov, O., Collombet, J. M. & Coutelle, C., 15 Jan 2000, In: Analytical Biochemistry. 277, 2, p. 236-242 6 p.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Is it congenital or acquired von Willebrands disease?

    Saif, MA., Thachil, J., Brown, R., Bigger, BW., Wynn, RF., Nash, M. & Hay, CR., Jan 2015, In: Haemophilia. 21, 1, p. e113-e115

    Research output: Contribution to journalArticlepeer-review

  8. Published

    Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice

    Waddington, S. N., Mitrophanous, K. A., Ellard, F. M., Buckley, S. M. K., Nivsarkar, M., Lawrence, L., Cook, H. T., Al-Allaf, F., Bigger, B., Kingsman, S. M., Coutelle, C. & Themis, M., Aug 2003, In: Gene Therapy. 10, 15, p. 1234-1240 6 p.

    Research output: Contribution to journalArticlepeer-review

  9. Published

    Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy

    Holley, R. J., Ellison, S. M., Fil, D., O'Leary, C., McDermott, J., Senthivel, N., Langford-Smith, A. W. W., Wilkinson, F. L., D'Souza, Z., Parker, H., Liao, A., Rowlston, S., Gleitz, H. F. E., Kan, S. H., Dickson, P. I. & Bigger, B. W., 1 Jan 2018, In: Brain. 141, 1, p. 99-116 18 p.

    Research output: Contribution to journalArticlepeer-review

  10. Published

    Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders

    Griffiths, W. J., Yutuc, E., Abdel-Khalik, J., Crick, P. J., Hearn, T., Dickson, A., Bigger, B. W., Hoi-Yee Wu, T., Goenka, A., Ghosh, A., Jones, S. A., Covey, D. F., Ory, D. S. & Wang, Y., 2019, In: Free Radical Biology and Medicine.

    Research output: Contribution to journalArticlepeer-review

Research Explorer downloads

112

Research output: Contribution to journalArticlepeer-review

21

Research output: Contribution to journalReview articlepeer-review