Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

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Publications

  1. 2019
  2. Published

    Strategies for the Induction of Immune Tolerance to Enzyme Replacement Therapy in Mucopolysaccharidosis Type I

    Ghosh, A., Liao, A., O'Leary, C., Mercer, J., Tylee, K., Goenka, A., Holley, R., Jones, S. A. & Bigger, B. W., 14 Jun 2019, In: Molecular Therapy - Methods and Clinical Development. 13, p. 321-333 13 p.

    Research output: Contribution to journalArticlepeer-review

  3. Published

    An Improved Adeno-Associated Virus Vector for Neurological Correction of the Mouse Model of Mucopolysaccharidosis IIIA

    Gray, A. L., O'Leary, C., Liao, A., Agúndez, L., Youshani, A. S., Gleitz, H. F., Parker, H., Taylor, J. T., Danos, O., Hocquemiller, M., Palomar, N., Linden, R. M., Henckaerts, E., Holley, R. J. & Bigger, B. W., 17 Sep 2019, In: Human Gene Therapy. 30, 9, p. 1052-1066 15 p.

    Research output: Contribution to journalArticlepeer-review

  4. Published

    Hampering brain tumor proliferation and migration using peptide nanofiber:siPLK1/MMP2 complexes

    Mazza, M., Ahmad, H., Hadjidemetriou, M., Agliardi, G., Pathmanaban, O. N., King, A. T., Bigger, B. W., Vranic, S. & Kostarelos, K., Dec 2019, In: nanomedicine. 14, 24, p. 3127-3142 16 p.

    Research output: Contribution to journalArticlepeer-review

  5. Published

    Post-transplant laronidase augmentation for children with Hurler syndrome: biochemical outcomes

    Lund, T. C., Miller, W. P., Liao, A. Y., Tolar, J., Shanley, R., Pasquali, M., Sando, N., Bigger, B. W., Polgreen, L. E. & Orchard, P. J., 1 Dec 2019, In: Scientific Reports. 9, 1, 14105.

    Research output: Contribution to journalArticlepeer-review

  6. 2020
  7. Published

    Haematopoietic stem cell gene therapy with IL-1Ra rescues cognitive loss in mucopolysaccharidosis IIIA

    Parker, H., Ellison, S. M., Holley, R. J., O'Leary, C., Liao, A., Asadi, J., Glover, E., Ghosh, A., Jones, S., Wilkinson, F. L., Brough, D., Pinteaux, E., Boutin, H. & Bigger, B. W., 6 Mar 2020, In: EMBO Molecular Medicine. 12, 3, e11185.

    Research output: Contribution to journalArticlepeer-review

  8. Published

    Actinomycin D Downregulates Sox2 and Improves Survival in Preclinical Models of Recurrent Glioblastoma

    Taylor, J. T., Ellison, S., Pandele, A., Wood, S., Nathan, E., Forte, G., Parker, H., Zindy, E., Elvin, M., Dickson, A., Williams, K. J., Karabatsou, K., McCabe, M., McBain, C. & Bigger, B. W., 30 Mar 2020, In: Neuro-Oncology. 22, 9, p. 1289-1301 13 p.

    Research output: Contribution to journalArticlepeer-review

  9. Published

    Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer

    Green, D., Eyre, H., Singh, A., Taylor, J., Chu, J., Jeys, L., Sumathi, V. P., Coonar, A., Rassl, D., Babur, M., Forster, D., Alzabin, S., Ponthan, F., McMahon, A., Bigger, B., Reekie, T., Kassiou, M., Williams, K., Dalmay, T., Fraser, W. D. & 1 others, Finegan, K., 13 Jul 2020, In: Oncogene. 39, p. 5553–5569

    Research output: Contribution to journalArticlepeer-review

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