Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

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Publications

  1. 2016
  2. Published

    Enzyme replacement therapy prior to haematopoietic stem cell transplantation in Mucopolysaccharidosis Type I: 10 year combined experience of 2 centres

    Ghosh, A., Miller, W., Orchard, P. J., Jones, S. A., Mercer, J., Church, H. J., Tylee, K., Lund, T., Bigger, B. W., Tolar, J. & Wynn, R. F., 1 Mar 2016, In: Molecular genetics and metabolism. 117, 3, p. 373-377 5 p.

    Research output: Contribution to journalArticlepeer-review

  3. 2017
  4. Published

    Mucopolysaccharidosis type IIIA storage substrate drives an innate immune neuro-inflammatory response

    Bigger, B., Boutin, H., Wilkinson, F., Holley, R., Brough, D., Pinteaux, E. & Parker, H., 2017, p. S27-S28.

    Research output: Contribution to conferenceAbstractpeer-review

  5. Published

    Recommendations on clinical trial design for treatment of Mucopolysaccharidosis Type III

    Ghosh, A., Shapiro, E., Rust, S., Delaney, K., Parker, S., Shaywitz, A. J., Morte, A., Bubb, G., Cleary, M., Bo, T., Lavery, C., Bigger, B. & Jones, S., 2017, In: Orphanet Journal of Rare Diseases.

    Research output: Contribution to journalArticlepeer-review

  6. Published

    Identification of Age-Dependent Motor and Neuropsychological Behavioural Abnormalities in a Mouse Model of Mucopolysaccharidosis Type II

    Gleitz, H., O'Leary, C., Holley, R. & Bigger, B., 16 Feb 2017, In: PLoS ONE.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients

    Griffiths, W. J., Abdel-Khalik, J., Crick, P. J., Ogundare, M., Shackleton, C. H., Tuschl, K., Kwok, M. K., Bigger, B. W., Morris, A. A., Honda, A., Xu, L., Porter, N. A., Björkhem, I., Clayton, P. T. & Wang, Y., 1 May 2017, In: Journal of Steroid Biochemistry and Molecular Biology.

    Research output: Contribution to journalArticlepeer-review

  8. 2018
  9. Published

    Anatomical changes and pathophysiology of the brain in mucopolysaccharidosis disorders

    Bigger, B. W., Begley, D. J., Virgintino, D. & Pshezhetsky, A. V., 2018, In: Molecular genetics and metabolism.

    Research output: Contribution to journalArticlepeer-review

  10. Published

    Delivering Hematopoietic Stem Cell Gene Therapy Treatments for Neurological Lysosomal Diseases.

    Holley, R., Wood, S. & Bigger, B., 2018, In: ACS Chemical Neuroscience.

    Research output: Contribution to journalReview articlepeer-review

  11. Published

    Identification Of Unusual Oxysterols And Bile acids With 7-Oxo Or 3β,5α,6β-Trihydroxy Functions In Human Plasma By Charge-Tagging Mass Spectrometry With Multistage Fragmentation

    Griffiths, W. J., Gilmore, I., Yutuc, E., Abdel-Khalik, J., Crick, P. J., Hearn, T., Dickson, A., Bigger, B. W., Goenka, A., Ghosh, A., Jones, S. A. & Wang, Y., 2018, In: Journal of Lipid Research. 59

    Research output: Contribution to journalArticlepeer-review

  12. Published

    The role of innate immunity in mucopolysaccharide diseases

    Parker, H. & Bigger, B. W., 2018, In: Journal of neurochemistry.

    Research output: Contribution to journalArticlepeer-review

  13. Published

    Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy

    Holley, R. J., Ellison, S. M., Fil, D., O'Leary, C., McDermott, J., Senthivel, N., Langford-Smith, A. W. W., Wilkinson, F. L., D'Souza, Z., Parker, H., Liao, A., Rowlston, S., Gleitz, H. F. E., Kan, S. H., Dickson, P. I. & Bigger, B. W., 1 Jan 2018, In: Brain. 141, 1, p. 99-116 18 p.

    Research output: Contribution to journalArticlepeer-review

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Research output: Contribution to journalReview articlepeer-review