Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

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Phone: +44 (0) 161 306 0516
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ORCID: 0000-0002-9708-1112
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Publications

41 - 50 out of 87Page size: 10
  1. 2013
  2. Published

    Busulfan conditioning enhances engraftment of hematopoietic donor-derived cells in the brain compared with irradiation

    Wilkinson, F. L., Sergijenko, A., Langford-Smith, K. J., Malinowska, M., Wynn, R. F. & Bigger, B. W., Apr 2013, In: Molecular Therapy. 21, 4, p. 868-876 8 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1038/mt.2013.29
  3. Published

    Analytical strategies for characterization of oxysterol lipidomes: Liver X receptor ligands in plasma

    Griffiths, W. J., Crick, P. J., Wang, Y., Ogundare, M., Tuschl, K., Morris, A. A., Bigger, B. W., Clayton, P. T. & Wang, Y., Jun 2013, In: Free Radical Biology and Medicine. 59, p. 69-84 15 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.freeradbiomed.2012.07.027
  4. Published

    Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice

    Denes, A., Wilkinson, F., Bigger, B., Chu, M., Rothwell, N. J. & Allan, S. M., Jul 2013, In: DMM Disease Models and Mechanisms. 6, 4, p. 1043-1048 5 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1242/dmm.011601
  5. Published

    Myeloid/Microglial driven autologous hematopoietic stem cell gene therapy corrects a neuronopathic lysosomal disease

    Sergijenko, A., Langford-Smith, A., Liao, A. Y., Pickford, C. E., McDermott, J., Nowinski, G., Langford-Smith, K. J., Merry, C. L., Jones, S. A., Wraith, J. E., Wynn, R. F., Wilkinson, F. L. & Bigger, B. W., Oct 2013, In: Molecular Therapy. 21, 10, p. 1938-1949 11 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1038/mt.2013.141
  6. Published

    Signal One and Two Blockade Are Both Critical for Non-Myeloablative Murine HSCT across a Major Histocompatibility Complex Barrier

    Langford-Smith, K. J., Sandiford, Z., Langford-Smith, A., Wilkinson, F. L., Jones, S. A., Wraith, J. E., Wynn, R. F. & Bigger, B. W., 17 Oct 2013, In: PLoS ONE. 8, 10, e77632.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1371/journal.pone.0077632
  7. 2014
  8. Published

    An investigation of the middle and late behavioural phenotypes of Mucopolysaccharidosis Type-III.

    Cross, E. M., Grant, S., Jones, S., Bigger, B. W., Wraith, J. E., Mahon, L. V., Lomax, M. & Hare, D. J., 2014, In: Journal of neurodevelopmental disorders. 6, 1

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1186/1866-1955-6-46
  9. Published

    Novel approaches and mechanisms in hematopoietic stem cell gene therapy

    Bigger, B. W. & Wynn, R. F., 2014, In: Discovery Medicine. 17, 94

    Research output: Contribution to journal › Article › peer-review

  10. Published

    Mucopolysaccharide diseases: A complex interplay between neuroinflammation, microglial activation and adaptive immunity

    Archer, L. D., Langford-Smith, K. J., Bigger, B. W. & Fildes, J. E., Jan 2014, In: Journal of Inherited Metabolic Disease. 37, 1, p. 1-12 11 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1007/s10545-013-9613-3
  11. Published

    Assessment of sleep in children with mucopolysaccharidosis type III

    Mahon, L. V., Lomax, M., Grant, S., Cross, E., Hare, D. J., Wraith, J. E., Jones, S., Bigger, B., Langford-Smith, K. & Canal, M., 4 Feb 2014, In: PLoS ONE. 9, 2, e84128.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1371/journal.pone.0084128
  12. Published

    Heparan sulfate inhibits hematopoietic stem and progenitor cell migration and engraftment in mucopolysaccharidosis I.

    Watson, H. A., Holley, R. J., Langford-Smith, K. J., Wilkinson, F. L., van Kuppevelt, T. H., Wynn, R. F., Wraith, J. E., Merry, C. L. R. & Bigger, B. W., 26 Dec 2014, In: The Journal of biological chemistry. 289, 52, p. 36194-36203 9 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1074/jbc.M114.599944
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Research Explorer downloads

110
Recommendations on clinical trial design for treatment of Mucopolysaccharidosis Type III

Research output: Contribution to journal › Article › peer-review

45
Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease

Research output: Contribution to journal › Article › peer-review

20
Delivering Hematopoietic Stem Cell Gene Therapy Treatments for Neurological Lysosomal Diseases.

Research output: Contribution to journal › Review article › peer-review