Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

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Publications

  1. 2009
  2. Published

    Cellular therapy of lysosomal storage disorders: Current status and future prospects

    Wynn, R. F., Stubbs, M., Ozyilmaz, N., Wraith, J. E. & Bigger, B., Aug 2009, In: Current Pediatric Reviews. 5, 3, p. 147-159 12 p.

    Research output: Contribution to journalArticlepeer-review

  3. Published

    Genistein reduces lysosomal storage in peripheral tissues of mucopolysaccharide IIIB mice

    Malinowska, M., Wilkinson, F. L., Bennett, W., Langford-Smith, K. J., O'Leary, H. A., Jakobkiewicz-Banecka, J., Wynn, R., Wraith, J. E., Wegrzyn, G. & Bigger, B. W., Nov 2009, In: Molecular genetics and metabolism. 98, 3, p. 235-242 7 p.

    Research output: Contribution to journalArticlepeer-review

  4. 2010
  5. Published

    Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease

    Malinowska, M., Wilkinson, F. L., Langford-Smith, K. J., Langford-Smith, A., Brown, J. R., Crawford, B. E., Vanier, M. T., Grynkiewicz, G., Wynn, R. F., Ed Wraith, J., Wegrzyn, G. & Bigger, B. W., 2010, In: PLoS ONE. 5, 12, e14192.

    Research output: Contribution to journalArticlepeer-review

  6. Published

    Successful allogeneic bone marrow transplant for Niemann-Pick disease type C2 is likely to be associated with a severe 'graft versus substrate' effect

    Bonney, D. K., O'Meara, A., Shabani, A., Imrie, J., Bigger, B. W., Jones, S., Wraith, J. E. & Wynn, R. F., 2010, In: Journal of Inherited Metabolic Disease. 33, 3, p. S171-S173

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Immune activation or immunomodulation in the brains of MPS IIIB mice? Commentary on "innate and adaptive immune activation in the brain of MPS IIIB mouse model"

    Archer, L. D., Langford, K., Bigger, B. & Fildes, J. E., 1 Feb 2010, In: Journal of Neuroscience Research. 88, 2, p. 233

    Research output: Contribution to journalArticlepeer-review

  8. Published

    Evaluation of heparin cofactor II-thrombin complex as a biomarker on blood spots from mucopolysaccharidosis I, IIIA and IIIB mice

    Langford-Smith, K., Arasaradnam, M., Wraith, J. E., Wynn, R. & Bigger, B. W., Mar 2010, In: Molecular genetics and metabolism. 99, 3, p. 269-274 5 p.

    Research output: Contribution to journalArticlepeer-review

  9. Published

    Circadian rhythm and suprachiasmatic nucleus alterations in the mouse model of mucopolysaccharidosis IIIB

    Canal, M. M., Wilkinson, F. L., Cooper, J. D., Ed Wraith, J., Wynn, R. & Bigger, B. W., 19 Jun 2010, In: Behavioural brain research. 209, 2, p. 212-220 8 p.

    Research output: Contribution to journalArticlepeer-review

  10. 2011
  11. Published

    Heparin cofactor II-thrombin complex and dermatan sulphate:chondroitin sulphate ratio are biomarkers of short- and long-term treatment effects in mucopolysaccharide diseases

    Langford-Smith, K. J., Mercer, J., Petty, J., Tylee, K., Church, H., Roberts, J., Moss, G., Jones, S., Wynn, R., Wraith, J. E. & Bigger, B. W., Apr 2011, In: Journal of Inherited Metabolic Disease. 34, 2, p. 499-508 9 p.

    Research output: Contribution to journalArticlepeer-review

  12. Published

    Chronic norovirus infection in pediatric hematopoietic stem cell transplant recipients: A cause of prolonged intestinal failure requiring intensive nutritional support

    Saif, M. A., Bonney, D. K., Bigger, B., Forsythe, L., Williams, N., Page, J., Babiker, Z. O., Guiver, M., Turner, A. J., Hughes, S. & Wynn, R. F., Aug 2011, In: Pediatric transplantation. 15, 5, p. 505-509 4 p.

    Research output: Contribution to journalArticlepeer-review

  13. Published

    Hyperactive behaviour in the mouse model of mucopolysaccharidosis iiib in the open field and home cage environments

    Langford-Smith, A., Malinowska, M., Langford-Smith, K. J., Wegrzyn, G., Jones, S., Wynn, R., Wraith, J. E., Wilkinson, F. L. & Bigger, B. W., Aug 2011, In: Genes, Brain and Behavior. 10, 6, p. 673-682 9 p.

    Research output: Contribution to journalArticlepeer-review

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