Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

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Publications

  1. 1999
  2. Published

    Tipping the scales in favour of mitochondrial gene therapy

    Bigger, B., Collombet, J. M. & Coutelle, C., Dec 1999, In: Gene Therapy. 6, 12, p. 1909-1910 1 p.

    Research output: Contribution to journalArticlepeer-review

  3. 2000
  4. Published

    Introduction of chloramphenicol resistance into the modified mouse mitochondrial genome: Cloning of unstable sequences by passage through yeast

    Bigger, B., Tolmachov, O., Collombet, J. M. & Coutelle, C., 15 Jan 2000, In: Analytical Biochemistry. 277, 2, p. 236-242 6 p.

    Research output: Contribution to journalArticlepeer-review

  5. 2001
  6. Published

    Gentherapie der zystischen fibrose: Eine analyse der bisherigen klinischen studien

    Coutelle, C. & Bigger, B., 2001, In: Internist. 42, 10, p. 1346-1356 10 p.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Perspectives on gene therapy for cystic fibrosis airway disease

    Bigger, B. & Coutelle, C., 2001, In: BioDrugs. 15, 9, p. 615-634 19 p.

    Research output: Contribution to journalArticlepeer-review

  8. Published

    An araC-controlled Bacterial cre Expression System to Produce DNA Minicircle Vectors for Nuclear and Mitochondrial Gene Therapy

    Bigger, B. W., Tolmachov, O., Collombet, J. M., Fragkos, M., Palaszewski, I. & Coutelle, C., 22 Jun 2001, In: Journal of Biological Chemistry. 276, 25, p. 23018-23027 9 p.

    Research output: Contribution to journalArticlepeer-review

  9. 2003
  10. Published

    Gene Therapy for Mitochondrial DNA Disorders

    Bigger, B., Lightowlers, R. N., Taylor, R. W., Turnbull, D. & Holt, IJ. (ed.), 2003, Genetics of Mitochondrial Diseases. Oxford: Oxford University Press

    Research output: Chapter in Book/Report/Conference proceedingChapter

  11. Published

    Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice

    Waddington, S. N., Mitrophanous, K. A., Ellard, F. M., Buckley, S. M. K., Nivsarkar, M., Lawrence, L., Cook, H. T., Al-Allaf, F., Bigger, B., Kingsman, S. M., Coutelle, C. & Themis, M., Aug 2003, In: Gene Therapy. 10, 15, p. 1234-1240 6 p.

    Research output: Contribution to journalArticlepeer-review

  12. 2004
  13. Published

    Hepatic stem cells: From inside and outside the liver?

    Alison, M. R., Vig, P., Russo, F., Bigger, B. W., Amofah, E., Themis, M. & Forbes, S., Feb 2004, In: Cell Proliferation. 37, 1, p. 1-21 20 p.

    Research output: Contribution to journalArticlepeer-review

  14. Published

    Development of a Self-assembling Nuclear Targeting Vector System Based on the Tetracycline Repressor Protein

    Vaysse, L., Harbottle, R., Bigger, B., Bergau, A., Tolmachov, O. & Coutelle, C., 13 Feb 2004, In: Journal of Biological Chemistry. 279, 7, p. 5555-5564 9 p.

    Research output: Contribution to journalArticlepeer-review

  15. Published

    Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy

    Bigger, B., Gregory, L. G., Waddington, S. N., Holder, M. V., Mitrophanous, K. A., Buckley, S. M. K., Mosley, K. L., Bigger, B. W., Ellard, F. M., Walmsley, L. E., Lawrence, L., Al-Allaf, F., Kingsman, S., Coutelle, C. & Themis, M., Jul 2004, In: Gene Therapy. 11, 14, p. 1117-1125 8 p.

    Research output: Contribution to journalArticlepeer-review

  16. Published

    Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy

    Waddington, S. N., Nivsarkar, M. S., Mistry, A. R., Buckley, S. M. K., Kemball-Cook, G., Mosley, K. L., Mitrophanous, K., Radcliffe, P., Holder, M. V., Brittan, M., Georgiadis, A., Al-Allaf, F., Bigger, B. W., Gregory, L. G., Terence Cook, H., Ali, R. R., Thrasher, A., Tuddenham, E. G. D., Themis, M. & Coutelle, C., 1 Nov 2004, In: Blood. 104, 9, p. 2714-2721 7 p.

    Research output: Contribution to journalArticlepeer-review

  17. 2005
  18. Published

    Minimised, CpG-depleted and methylated DNA vectors: Towards perfection in non-viral gene therapy

    Bigger, B. W., Tolmachov, O., Harbottle, R., Coutelle, C. & Schleef, M. (ed.), 2005, DNA-Pharmaceuticals: Formulation and delivery in gene therapy, DNA vaccination and immunotherapy. Cambridge, UK: John Wiley & Sons Ltd

    Research output: Chapter in Book/Report/Conference proceedingChapter

  19. Published

    Comparison of HIV- and EIAV-based vectors on their efficiency in transducing murine and human hematopoietic repopulating cells

    Siapati, E. K., Bigger, B. W., Miskin, J., Chipchase, D., Parsley, K. L., Mitrophanous, K., Themis, M., Thrasher, A. J. & Bonnet, D., Sep 2005, In: Molecular Therapy. 12, 3, p. 537-546 9 p.

    Research output: Contribution to journalArticlepeer-review

  20. Published

    Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice

    Themis, M., Waddington, S. N., Schmidt, M., von Kalle, C., Wang, Y., Al-Allaf, F., Gregory, L. G., Nivsarkar, M., Themis, M., Holder, M. V., Buckley, S. M. K., Dighe, N., Ruthe, A. T., Mistry, A., Bigger, B., Rahim, A., Nguyen, T. H., Trono, D., Thrasher, A. J. & Coutelle, C., Oct 2005, In: Molecular Therapy. 12, 4, p. 763-771 8 p.

    Research output: Contribution to journalArticlepeer-review

  21. 2006
  22. Published

    Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX

    Bigger, B., Siapati, E. K., Mistry, A., Waddington, S. N., Nivsarkar, M. S., Jacobs, L., Perrett, R., Holder, M. V., Ridler, C., Kemball-Cook, G., Ali, R. R., Forbes, S. J., Coutelle, C., Wright, N., Alison, M., Thrasher, A. J., Bonnet, D. & Themis, M., Jan 2006, In: Gene Therapy. 13, 2, p. 117-126 9 p.

    Research output: Contribution to journalArticlepeer-review

  23. Published

    RecET driven chromosomal gene targeting to generate a RecA deficient Escherichia coli strain for Cre mediated production of minicircle DNA

    Tolmachov, O., Palaszewski, I., Bigger, B. & Coutelle, C., 10 Mar 2006, In: BMC Biotechnology. 6, 17.

    Research output: Contribution to journalArticlepeer-review

  24. Published

    The Bone Marrow Functionally Contributes to Liver Fibrosis

    Russo, F. P., Alison, M. R., Bigger, B. W., Amofah, E., Florou, A., Amin, F., Bou-Gharios, G., Jeffery, R., Iredale, J. P. & Forbes, S. J., Jun 2006, In: Gastroenterology. 130, 6, p. 1807-1821 14 p.

    Research output: Contribution to journalArticlepeer-review

  25. 2007
  26. Published

    Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells

    Siapati, E. K., Bigger, B. W., Kashofer, K., Themis, M., Thrasher, A. J. & Bonnet, D., Apr 2007, In: European journal of haematology. 78, 4, p. 303-313 10 p.

    Research output: Contribution to journalArticlepeer-review

  27. Published

    Xenogenic transfer of isolated murine mitochondria into human ρ0 cells can improve respiratory function

    Katrangi, E., D'Souza, G., Boddapati, S. V., Kulawiec, M., Singh, K. K., Bigger, B. & Weissig, V., 1 Dec 2007, In: Rejuvenation Research. 10, 4, p. 561-570 9 p.

    Research output: Contribution to journalArticlepeer-review

  28. 2009
  29. Published

    Improved Metabolic Correction in Patients with Lysosomal Storage Disease Treated with Hematopoietic Stem Cell Transplant Compared with Enzyme Replacement Therapy

    Wynn, R. F., Wraith, J. E., Mercer, J., O'Meara, A., Tylee, K., Thornley, M., Church, H. J. & Bigger, B. W., Apr 2009, In: Journal Of Pediatrics. 154, 4, p. 609-611 2 p.

    Research output: Contribution to journalArticlepeer-review

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