Prof Brian Bigger PhD

Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells

Siapati, E. K., Bigger, B. W., Kashofer, K., Themis, M., Thrasher, A. J. & Bonnet, D., Apr 2007, In: European journal of haematology. 78, 4, p. 303-313 10 p.

Research output: Contribution to journal › Article › peer-review

Comparison of HIV- and EIAV-based vectors on their efficiency in transducing murine and human hematopoietic repopulating cells

Siapati, E. K., Bigger, B. W., Miskin, J., Chipchase, D., Parsley, K. L., Mitrophanous, K., Themis, M., Thrasher, A. J. & Bonnet, D., Sep 2005, In: Molecular Therapy. 12, 3, p. 537-546 9 p.

Research output: Contribution to journal › Article › peer-review

Actinomycin D Downregulates Sox2 and Improves Survival in Preclinical Models of Recurrent Glioblastoma

Taylor, J. T., Ellison, S., Pandele, A., Wood, S., Nathan, E., Forte, G., Parker, H., Zindy, E., Elvin, M., Dickson, A., Williams, K. J., Karabatsou, K., McCabe, M., McBain, C. & Bigger, B. W., 30 Mar 2020, In: Neuro-Oncology. 22, 9, p. 1289-1301 13 p.

Research output: Contribution to journal › Article › peer-review

Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice

Themis, M., Waddington, S. N., Schmidt, M., von Kalle, C., Wang, Y., Al-Allaf, F., Gregory, L. G., Nivsarkar, M., Themis, M., Holder, M. V., Buckley, S. M. K., Dighe, N., Ruthe, A. T., Mistry, A., Bigger, B., Rahim, A., Nguyen, T. H., Trono, D., Thrasher, A. J. & Coutelle, C., Oct 2005, In: Molecular Therapy. 12, 4, p. 763-771 8 p.

Research output: Contribution to journal › Article › peer-review

RecET driven chromosomal gene targeting to generate a RecA deficient Escherichia coli strain for Cre mediated production of minicircle DNA

Tolmachov, O., Palaszewski, I., Bigger, B. & Coutelle, C., 10 Mar 2006, In: BMC Biotechnology. 6, 17.

Research output: Contribution to journal › Article › peer-review

A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency

Tordo, J., O'Leary, C., Antunes, A. S. L. M., Palomar, N., Aldrin-Kirk, P., Basche, M., Bennett, A., D'Souza, Z., Gleitz, H., Godwin, A., Holley, R., Parker, H., Liao, A., Rouse, P., Youshani, A., Dridi, L., Martins, C., Levade, T., Stacey, K., Davis, D. M. & 11 others, Dyer, A., Clement, N., Bjorklund, T., Ali, R. R., Agbandje-McKenna, M., Rahim, A., Pshezhetsky, A. V., Waddington, S. N., Linden, R. M., Bigger, B. & Henckaerts, E., 16 May 2018, In: Brain. 141, 7, p. 2014-2031 18 p.

Research output: Contribution to journal › Article › peer-review

Development of a Self-assembling Nuclear Targeting Vector System Based on the Tetracycline Repressor Protein

Vaysse, L., Harbottle, R., Bigger, B., Bergau, A., Tolmachov, O. & Coutelle, C., 13 Feb 2004, In: Journal of Biological Chemistry. 279, 7, p. 5555-5564 9 p.

Research output: Contribution to journal › Article › peer-review

Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice

Waddington, S. N., Mitrophanous, K. A., Ellard, F. M., Buckley, S. M. K., Nivsarkar, M., Lawrence, L., Cook, H. T., Al-Allaf, F., Bigger, B., Kingsman, S. M., Coutelle, C. & Themis, M., Aug 2003, In: Gene Therapy. 10, 15, p. 1234-1240 6 p.

Research output: Contribution to journal › Article › peer-review

Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy

Waddington, S. N., Nivsarkar, M. S., Mistry, A. R., Buckley, S. M. K., Kemball-Cook, G., Mosley, K. L., Mitrophanous, K., Radcliffe, P., Holder, M. V., Brittan, M., Georgiadis, A., Al-Allaf, F., Bigger, B. W., Gregory, L. G., Terence Cook, H., Ali, R. R., Thrasher, A., Tuddenham, E. G. D., Themis, M. & Coutelle, C., 1 Nov 2004, In: Blood. 104, 9, p. 2714-2721 7 p.

Research output: Contribution to journal › Article › peer-review

Heparan sulfate inhibits hematopoietic stem and progenitor cell migration and engraftment in mucopolysaccharidosis I.

Watson, H. A., Holley, R. J., Langford-Smith, K. J., Wilkinson, F. L., van Kuppevelt, T. H., Wynn, R. F., Wraith, J. E., Merry, C. L. R. & Bigger, B. W., 26 Dec 2014, In: The Journal of biological chemistry. 289, 52, p. 36194-36203 9 p.

Research output: Contribution to journal › Article › peer-review