Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

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Phone: +44 (0) 161 306 0516
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ORCID: 0000-0002-9708-1112
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Publications

1 - 10 out of 87Page size: 10
  1. Published

    Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia

    Al-Allaf, F. A., Abduljaleel, Z., Athar, M., Taher, M. M., Khan, W., Mehmet, H., Colakogullari, M., Apostolidou, S., Bigger, B., Waddington, S., Coutelle, C., Themis, M., Al-Ahdal, M. N., Al-Mohanna, F. A., Al-Hassnan, Z. N. & Bouazzaoui, A., Mar 2019, In: Non-coding RNA research. 4, 1, p. 1-14 14 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.ncrna.2018.11.005
  2. Published

    Hepatic stem cells: From inside and outside the liver?

    Alison, M. R., Vig, P., Russo, F., Bigger, B. W., Amofah, E., Themis, M. & Forbes, S., Feb 2004, In: Cell Proliferation. 37, 1, p. 1-21 20 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1111/j.1365-2184.2004.00297.x
  3. Published

    Immune activation or immunomodulation in the brains of MPS IIIB mice? Commentary on "innate and adaptive immune activation in the brain of MPS IIIB mouse model"

    Archer, L. D., Langford, K., Bigger, B. & Fildes, J. E., 1 Feb 2010, In: Journal of Neuroscience Research. 88, 2, p. 233

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1002/jnr.22211
  4. Published

    Mucopolysaccharide diseases: A complex interplay between neuroinflammation, microglial activation and adaptive immunity

    Archer, L. D., Langford-Smith, K. J., Bigger, B. W. & Fildes, J. E., Jan 2014, In: Journal of Inherited Metabolic Disease. 37, 1, p. 1-12 11 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1007/s10545-013-9613-3
  5. Published

    Characterisation of the T cell and dendritic cell repertoire in a murine model of mucopolysaccharidosis i (MPS I)

    Archer, L. D., Langford-Smith, K. J., Critchley, W. R., Bigger, B. W. & Fildes, J. E., Mar 2013, In: Journal of Inherited Metabolic Disease. 36, 2, p. 257-262 5 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1007/s10545-012-9508-8
  6. Published

    The role of antibodies in enzyme treatments and therapeutic strategies.

    Bigger, B. W., Saif, M. & Linthorst, G. E., Mar 2015, In: Best practice & research. Clinical endocrinology & metabolism. 29, 2

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.beem.2015.01.006
  7. Published

    Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy

    Bigger, B., Gregory, L. G., Waddington, S. N., Holder, M. V., Mitrophanous, K. A., Buckley, S. M. K., Mosley, K. L., Bigger, B. W., Ellard, F. M., Walmsley, L. E., Lawrence, L., Al-Allaf, F., Kingsman, S., Coutelle, C. & Themis, M., Jul 2004, In: Gene Therapy. 11, 14, p. 1117-1125 8 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1038/sj.gt.3302268
  8. Published

    Perspectives on gene therapy for cystic fibrosis airway disease

    Bigger, B. & Coutelle, C., 2001, In: BioDrugs. 15, 9, p. 615-634 19 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.2165/00063030-200115090-00006
  9. Published

    Gene Therapy for Mitochondrial DNA Disorders

    Bigger, B., Lightowlers, R. N., Taylor, R. W., Turnbull, D. & Holt, IJ. (ed.), 2003, Genetics of Mitochondrial Diseases. Oxford: Oxford University Press

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

  10. Published

    Minimised, CpG-depleted and methylated DNA vectors: Towards perfection in non-viral gene therapy

    Bigger, B. W., Tolmachov, O., Harbottle, R., Coutelle, C. & Schleef, M. (ed.), 2005, DNA-Pharmaceuticals: Formulation and delivery in gene therapy, DNA vaccination and immunotherapy. Cambridge, UK: John Wiley & Sons Ltd

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

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Research Explorer downloads

106
Recommendations on clinical trial design for treatment of Mucopolysaccharidosis Type III

Research output: Contribution to journal › Article › peer-review

45
Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease

Research output: Contribution to journal › Article › peer-review

18
Delivering Hematopoietic Stem Cell Gene Therapy Treatments for Neurological Lysosomal Diseases.

Research output: Contribution to journal › Review article › peer-review