Prof Brian Bigger PhD

Professor of Cell and Gene Therapy

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Publications

  1. 2020
  2. Accepted/In press

    Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer

    Green, D., Eyre, H., Singh, A., Taylor, J., Chu, J., Jeys, L., Sumathi, V. P., Coonar, A., Rassl, D., Babur, M., Forster, D., Alzabin, S., Ponthan, F., McMahon, A., Bigger, B., Reekie, T., Kassiou, M., Williams, K., Dalmay, T., Fraser, W. D. & 1 others, Finegan, K., 22 May 2020, (Accepted/In press) In : Oncogene.

    Research output: Contribution to journalArticlepeer-review

  3. E-pub ahead of print

    Actinomycin D Downregulates Sox2 and Improves Survival in Preclinical Models of Recurrent Glioblastoma

    Taylor, J. T., Ellison, S., Pandele, A., Wood, S., Nathan, E., Forte, G., Parker, H., Zindy, E., Elvin, M., Dickson, A., Williams, K. J., Karabatsou, K., McCabe, M., McBain, C. & Bigger, B. W., 30 Mar 2020, In : Neuro-Oncology.

    Research output: Contribution to journalArticlepeer-review

  4. E-pub ahead of print

    Haematopoietic stem cell gene therapy with IL-1Ra rescues cognitive loss in mucopolysaccharidosis IIIA

    Parker, H., Ellison, S. M., Holley, R. J., O'Leary, C., Liao, A., Asadi, J., Glover, E., Ghosh, A., Jones, S., Wilkinson, F. L., Brough, D., Pinteaux, E., Boutin, H. & Bigger, B. W., 14 Feb 2020, In : EMBO Molecular Medicine. p. e11185

    Research output: Contribution to journalArticlepeer-review

  5. 2019
  6. Published

    Post-transplant laronidase augmentation for children with Hurler syndrome: biochemical outcomes

    Lund, T. C., Miller, W. P., Liao, A. Y., Tolar, J., Shanley, R., Pasquali, M., Sando, N., Bigger, B. W., Polgreen, L. E. & Orchard, P. J., 1 Dec 2019, In : Scientific Reports. 9, 1, 14105.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Hampering brain tumor proliferation and migration using peptide nanofiber:siPLK1/MMP2 complexes

    Mazza, M., Ahmad, H., Hadjidemetriou, M., Agliardi, G., Pathmanaban, O. N., King, A. T., Bigger, B. W., Vranic, S. & Kostarelos, K., Dec 2019, In : nanomedicine. 14, 24, p. 3127-3142 16 p.

    Research output: Contribution to journalArticlepeer-review

  8. Published

    An Improved Adeno-Associated Virus Vector for Neurological Correction of the Mouse Model of Mucopolysaccharidosis IIIA

    Gray, A. L., O'Leary, C., Liao, A., Agúndez, L., Youshani, A. S., Gleitz, H. F., Parker, H., Taylor, J. T., Danos, O., Hocquemiller, M., Palomar, N., Linden, R. M., Henckaerts, E., Holley, R. J. & Bigger, B. W., 17 Sep 2019, In : Human Gene Therapy. 30, 9, p. 1052-1066 15 p.

    Research output: Contribution to journalArticlepeer-review

  9. Published

    Pre-clinical Safety and Efficacy of Lentiviral Vector-Mediated Ex Vivo Stem Cell Gene Therapy for the Treatment of Mucopolysaccharidosis IIIA

    Ellison, S. M., Liao, A., Wood, S., Taylor, J., Youshani, A. S., Rowlston, S., Parker, H., Armant, M., Biffi, A., Chan, L., Farzaneh, F., Wynn, R., Jones, S. A., Heal, P., Gaspar, H. B. & Bigger, B. W., 14 Jun 2019, In : Molecular Therapy - Methods and Clinical Development. 13, p. 399-413 15 p.

    Research output: Contribution to journalArticlepeer-review

  10. Published

    Strategies for the Induction of Immune Tolerance to Enzyme Replacement Therapy in Mucopolysaccharidosis Type I

    Ghosh, A., Liao, A., O'Leary, C., Mercer, J., Tylee, K., Goenka, A., Holley, R., Jones, S. A. & Bigger, B. W., 14 Jun 2019, In : Molecular Therapy - Methods and Clinical Development. 13, p. 321-333 13 p.

    Research output: Contribution to journalArticlepeer-review

  11. Published

    Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia

    Al-Allaf, F. A., Abduljaleel, Z., Athar, M., Taher, M. M., Khan, W., Mehmet, H., Colakogullari, M., Apostolidou, S., Bigger, B., Waddington, S., Coutelle, C., Themis, M., Al-Ahdal, M. N., Al-Mohanna, F. A., Al-Hassnan, Z. N. & Bouazzaoui, A., Mar 2019, In : Non-coding RNA research. 4, 1, p. 1-14 14 p.

    Research output: Contribution to journalArticlepeer-review

  12. Published

    A nonmyeloablative chimeric mouse model accurately defines microglia and macrophage contribution in glioma

    Yu, K., Youshani, A. S., Wilkinson, F. L., O'Leary, C., Cook, P., Laaniste, L., Liao, A., Mosses, D., Waugh, C., Shorrock, H., Pathmanaban, O., Macdonald, A., Kamaly-Asl, I., Roncaroli, F. & Bigger, B. W., 1 Feb 2019, In : Neuropathology and Applied Neurobiology. 45, 2, p. 119-140 22 p.

    Research output: Contribution to journalArticlepeer-review

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