Prof Brian BiggerPhD

Professor of Cell and Gene Therapy

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Publications

  1. 2019
  2. Published

    Pre-clinical Safety and Efficacy of Lentiviral Vector-Mediated Ex Vivo Stem Cell Gene Therapy for the Treatment of Mucopolysaccharidosis IIIA

    Ellison, S. M., Liao, A., Wood, S., Taylor, J., Youshani, A. S., Rowlston, S., Parker, H., Armant, M., Biffi, A., Chan, L., Farzaneh, F., Wynn, R., Jones, S. A., Heal, P., Gaspar, H. B. & Bigger, B. W., 14 Jun 2019, In : Molecular Therapy - Methods and Clinical Development. 13, p. 399-413 15 p.

    Research output: Contribution to journalArticle

  3. Published

    Strategies for the Induction of Immune Tolerance to Enzyme Replacement Therapy in Mucopolysaccharidosis Type I

    Ghosh, A., Liao, A., O'Leary, C., Mercer, J., Tylee, K., Goenka, A., Holley, R., Jones, S. A. & Bigger, B. W., 14 Jun 2019, In : Molecular Therapy - Methods and Clinical Development. 13, p. 321-333 13 p.

    Research output: Contribution to journalArticle

  4. Published

    A nonmyeloablative chimeric mouse model accurately defines microglia and macrophage contribution in glioma

    Yu, K., Youshani, A. S., Wilkinson, F. L., O'Leary, C., Cook, P., Laaniste, L., Liao, A., Mosses, D., Waugh, C., Shorrock, H., Pathmanaban, O., Macdonald, A., Kamaly-Asl, I., Roncaroli, F. & Bigger, B. W., 1 Feb 2019, In : Neuropathology and Applied Neurobiology. 45, 2, p. 119-140 22 p.

    Research output: Contribution to journalArticle

  5. Published

    Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders

    Griffiths, W. J., Yutuc, E., Abdel-Khalik, J., Crick, P. J., Hearn, T., Dickson, A., Bigger, B. W., Hoi-Yee Wu, T., Goenka, A., Ghosh, A., Jones, S. A., Covey, D. F., Ory, D. S. & Wang, Y., 2019, In : Free Radical Biology and Medicine.

    Research output: Contribution to journalArticle

  6. Published

    Non-myeloablative busulfan chimeric mouse models are less pro-inflammatory than head-shielded irradiation for studying immune cell interactions in brain tumours

    Youshani, A. S., Rowlston, S., O'Leary, C., Forte, G., Parker, H., Liao, A., Telfer, B., Williams, K., Kamaly-Asl, I. D. & Bigger, B. W., 2019, In : Journal of Neuroinflammation. 16, 1, 25.

    Research output: Contribution to journalArticle

  7. 2018
  8. Published

    Substrate accumulation and extracellular matrix remodelling promote persistent upper airway disease in mucopolysaccharidosis patients on enzyme replacement therapy

    Pal, A. R., Mercer, J., Jones, S. A., Bruce, I. A., Bigger, B. W. & Dardis, A. (ed.), 18 Sep 2018, In : PLoS ONE. 13, 9, p. e0203216

    Research output: Contribution to journalArticle

  9. Published

    Brain‐targeted stem cell gene therapy corrects mucopolysaccharidosis type II via multiple mechanisms

    Gleitz, H. F., Liao, A. Y., Cook, J. R., Rowlston, S. F., Forte, G. M., D'souza, Z., O'leary, C., Holley, R. J. & Bigger, B. W., 1 Jul 2018, In : EMBO Molecular Medicine . 10, 7, p. e8730

    Research output: Contribution to journalArticle

  10. Published

    High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma

    Yu, K. K. H., Taylor, J. T., Pathmanaban, O. N., Youshani, A. S., Beyit, D., Dutko-Gwozdz, J., Benson, R., Griffiths, G., Peers, I., Cueppens, P., Telfer, B. A., Williams, K. J., McBain, C., Kamaly-Asl, I. D. & Bigger, B. W., 2 Mar 2018, In : PLoS ONE. 13, 3, e0193694.

    Research output: Contribution to journalArticle

  11. Published

    Interleukin-1 plays a central role in behaviour abnormalities in mucopolysaccharidosis type III (MPS HI)

    Bigger, B. W., Holley, R., Ellison, S., O'Leary, C., Pinteaux, E., Boutin, H. & Parker, H., Feb 2018, In : Molecular genetics and metabolism. 123, 2, p. S24-S25

    Research output: Contribution to journalMeeting Abstract

  12. Published

    Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy

    Holley, R. J., Ellison, S. M., Fil, D., O'Leary, C., McDermott, J., Senthivel, N., Langford-Smith, A. W. W., Wilkinson, F. L., D'Souza, Z., Parker, H., Liao, A., Rowlston, S., Gleitz, H. F. E., Kan, S. H., Dickson, P. I. & Bigger, B. W., 1 Jan 2018, In : Brain. 141, 1, p. 99-116 18 p.

    Research output: Contribution to journalArticle

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