Dr Brahim Achour

Research Associate

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Publications

  1. 2019
  2. E-pub ahead of print
  3. Published
  4. Published

    Proteomic Quantification of Human Blood-Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients

    Al-Majdoub, Z., Al Feteisi, H., Achour, B., Warwood, S., Neuhoff, S., Rostami-Hodjegan, A. & Barber, J., 2019, In : Molecular Pharmaceutics.

    Research output: Contribution to journalArticle

  5. Published
  6. Published

    Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

    Prasad, B., Achour, B., Artursson, P., Hop, C., Lai, Y., Smith, P. C., Barber, J., Wiśniewski, J. R., Spellman, D., Uchida, Y., Zientek, M., Unadkat, J. D. & Rostami-Hodjegan, A., 2019, In : Clinical Pharmacology & Therapeutics.

    Research output: Contribution to journalArticle

  7. 2018
  8. Published
  9. Published

    Identification and Quantification of Blood-Brain Barrier Transporters in Isolated Rat Brain Microvessels

    Al Feteisi, H., Al-Majdoub, Z., Achour, B., Couto, N., Rostami-Hodjegan, A. & Barber, J., Sep 2018, In : Journal of neurochemistry. 146, 6, p. 670-685

    Research output: Contribution to journalArticle

  10. Published
  11. Published

    Data generated by quantitative LC-MS proteomics are only the start and not the endpoint: Optimization of QconCAT-based measurement of hepatic UDP-glucuronosyltransferase enzymes with reference to catalytic activity

    Achour, B., Dantonio, A. L., Niosi, M., Novak, J. J., Al-Majdoub, Z., Goosen, T. C., Rostami-Hodjegan, A. & Barber, J., 1 Jun 2018, In : Drug Metabolism and Disposition. 46, 6, p. 805-812 8 p.

    Research output: Contribution to journalArticle

  12. Published

    Implications of inter-correlation between hepatic CYP3A4-CYP2C8 enzymes for the evaluation of drug-drug interactions: A case study with repaglinide

    Doki, K., Darwich, A., Achour, B., Tornio, A., Backman, J. T. & Rostami-Hochaghan, A., May 2018, In : British Journal of Clinical Pharmacology. 84, 5, p. 972–986 15 p.

    Research output: Contribution to journalArticle

  13. 2017
  14. Published

    Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

    Achour, B., Dantonio, A., Niosi, M., Novak, J. J., Fallon, J. K., Barber, J., Smith, P. C., Rostami-Hochaghan, A. & Goosen, T. C., 1 Oct 2017, In : Drug Metabolism and Disposition. 45, 10, p. 1102-1112 11 p.

    Research output: Contribution to journalArticle

  15. Published

    Quantitative Proteomic Analysis of Drug Transporters in Human Blood Brain Barrier

    Al-Majdoub, Z., Al Feteisi, H., Achour, B., Rostami-Hochaghan, A. & Barber, J., 19 Sep 2017.

    Research output: Contribution to conferencePoster

  16. Published

    Quantitative Proteomic Analysis of Drug Transporters in Human Blood Brain Barrier

    Al-Majdoub, Z., Al Feteisi, H., Achour, B., Rostami-Hodjegan, A. & Barber, J., 19 Sep 2017, HUPO2017.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  17. Published

    Cross-laboratory evaluation of UDP-glucuronosyltransferase (UGT) abundances and correlation with catalytic activity

    Achour, B., Dantonio, A. L., Niosi, M., Novak, J. J., Fallon, J. K., Barber, J., Smith, P. C., Rostami-Hochaghan, A. & Goosen, T. C., 26 Jun 2017.

    Research output: Contribution to conferencePoster

  18. Published

    Variability in protein quantification using different mass spectrometry-based proteomics workflows

    Wegler, C., Gaugaz, F. Z., Andersson, T. B., Oswald, S., Busch, D., Weiss, F., Hammer, H., Poetz, O., Wortelboer, H. M., Steeg, E. V. D., Achour, B., Rostami-Hochaghan, A. & Artursson, P., 26 Jun 2017.

    Research output: Contribution to conferencePoster

  19. Published

    Inter-laboratory variability in mass spectrometry-based proteomics workflows

    Wegler, C., Gaugaz, F. Z., Andersson, T. B., Wiśniewski, J. R., Oswald, S., Gröer, C., Busch, D., Weiss, F., Hammer, H., Joos, T. O., Poetz, O., Wortelboer, H., Steeg, E. V. D., Achour, B., Rostami-Hochaghan, A. & Artursson, P., 21 May 2017.

    Research output: Contribution to conferencePoster

  20. Published

    Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes

    Achour, B., Al Feteisi, H., Lanucara, F., Rostami-Hochaghan, A. & Barber, J., 11 May 2017, In : Drug Metabolism and Disposition. 45, 6, p. 666-675 10 p.

    Research output: Contribution to journalArticle

  21. Published

    Variability in mass spectrometry-based quantification of clinically relevant drug transporters and drug metabolizing enzymes

    Wegler, C., Gaugaz, F. Z., Andersson, T. B., Wiśniewski, J. R., Busch, D., Gröer, C., Oswald, S., Weiss, F., Hammer, H., Joos, T. O., Poetz, O., Achour, B., Rostami-Hochaghan, A., Steeg, E. V. D., Wortelboer, H. M. & Artursson, P., 2017, In : Molecular Pharmaceutics. 14, 9, p. 3142-3151 10 p.

    Research output: Contribution to journalArticle

  22. 2016
  23. Published

    Protein quantification of human hepatic drug transporters and metabolizing enzymes: an inter-laboratory and methodological comparison

    Wegler, C., Gaugaz, F. Z., Andersson, T. B., Wiśniewski, J. R., Busch, D., Oswald, S., Weiss, F., Hammer, H., Poetz, O., Joos, T. O., Wortelboer, H. M., Steeg, E. V. D., Achour, B., Rostami-Hochaghan, A. & Artursson, P., 15 Jul 2016, In : Drug Metabolism Reviews. 48, S1, p. 98-98 1 p.

    Research output: Contribution to journalMeeting Abstract

  24. Published
  25. Published

    Establishing the Relationship between mRNA Expression and Protein Abundance for Seven Transporters in Human Small Intestine: A Pilot Study

    Harwood, M. D., Gibson, S. L., Achour, B., Davies, P. J., Carlson, G. L., Rostami-Hodjegan, A. & Warhurst, G., 28 Jan 2016.

    Research output: Contribution to conferencePoster

  26. Published

    In vitro-in vivo extrapolation scaling factors for intestinal P-glycoprotein and breast cancer resistance protein: Part II. The impact of cross-laboratory variations of intestinal transporter relative expression factors on predicted drug disposition

    Harwood, M. D., Achour, B., Neuhoff, S., Russell, M. R., Carlson, G., Warhurst, G. & Rostami-Hodjegan, A., 2016, In : Drug Metabolism and Disposition. 44, 3, p. 476-480 5 p.

    Research output: Contribution to journalArticle

  27. 2015
  28. Published
  29. Published

    Ten years of QconCATs: Application of multiplexed quantification to small medically-relevant proteomes

    Achour, B., Al-Majdoub, Z., Al Feteisi, H., Elmorsi, Y., Rostami-Hochaghan, A. & Barber, J., 30 Nov 2015, In : International Journal of Mass Spectrometry. 391, 2015, p. 93-104 12 p.

    Research output: Contribution to journalArticle

  30. Published
  31. Published
  32. Published

    Towards more Realistic Clinical Trial Simulation: Establishing Inter-Correlations between Several Cytochrome P450 Enzyme Abundances in Human Liver

    Wedagedera, J. R., Abduljalil, K., Cain, T., Achour, B., Pathak, S., Dunlavey, M., Jamei, M. & Rostami-Hodjegan, A., 2 Jun 2015.

    Research output: Contribution to conferencePoster

  33. Published

    Meta-analysis of Expression of Hepatic Organic Anion Transporting Polypeptide (OATP) Transporters in Cellular Systems Relative to Human Liver Tissue

    Badée, J., Achour, B., Rostami-Hochaghan, A. & Galetin, A., Apr 2015, In : Drug Metabolism and Disposition. 43, 4, p. 424-432 9 p.

    Research output: Contribution to journalArticle

  34. Published
  35. Published

    Application of an LC-MS/MS Method for the Simultaneous Quantification of Human Intestinal Transporter Proteins Absolute Abundance using a QconCAT Technique

    Harwood, M. D., Achour, B., Russell, M. R., Carlson, G. L., Warhurst, G. & Rostami-Hodjegan, A., 28 Feb 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 110, p. 27-33 7 p.

    Research output: Contribution to journalArticle

  36. Published

    How LC-MS Proteomics is Revolutionizing PBPK Modelling and Simulation

    Achour, B. & Rostami-Hodjegan, A., 18 Feb 2015.

    Research output: Contribution to conferenceOther

  37. Published
  38. Published

    Label-Free Method for Profiling Human Liver Enzymes: Validation with QconCAT

    Achour, B., Lanucara, F., Feteisi, H. A., Barber, J. & Rostami-Hodjegan, A., 2015.

    Research output: Contribution to conferencePoster

  39. Published

    Laboratory differences in relative expression factors generated for intestinal P-glycoprotein and Breast Cancer Resistance Protein: Relevance to in vitro-in vivo extrapolation

    Harwood, M. D., Achour, B., Neuhoff, S., Carlson, G., Warhurst, G. & Rostami-Hodjegan, A., 2015.

    Research output: Contribution to conferencePoster

  40. Published

    Protein quantification of human hepatic drug transporters and metabolizing enzymes: an inter-laboratory and methodological comparison

    Wegler, C., Gaugaz, F. Z., Andersson, T. B., Wiśniewski, J. R., Oswald, S., Busch, D., Weiss, F., Hammer, H., Joos, T. O., Poetz, O., Wortelboer, H., Steeg, E. V. D., Achour, B., Rostami-Hodjegan, A. & Artursson, P., 2015.

    Research output: Contribution to conferencePoster

  41. 2014
  42. Published

    A Cross-Laboratory Comparison of Caco-2 and Human Intestinal Drug Transporter Protein Abundances

    Harwood, M. D., Achour, B., Courbebaisse, Y., Russell, M. R., Neuhoff, S., Carlson, G., Warhurst, G. & Rostami-Hodjegan, A., Oct 2014.

    Research output: Contribution to conferencePoster

  43. Published
  44. Published

    Expression of Hepatic Drug-Metabolizing Cytochrome P450 Enzymes and Their Inter-Correlations: A Meta-Analysis.

    Achour, B., Barber, J. & Rostami-Hodjegan, A., 2014, In : Drug Metabolism and Disposition. 42, 8, p. 1349-1356 7 p.

    Research output: Contribution to journalArticle

  45. Published

    Protein expression of various hepatic uridine 5'-diphosphate glucuronosyltransferase (UGT) enzymes and their inter-correlations: A meta-analysis

    Achour, B., Rostami-Hodjegan, A. & Barber, J., 2014, In : Biopharmaceutics and Drug Disposition. 35, p. 353-361 9 p.

    Research output: Contribution to journalArticle

  46. Published
  47. 2013
  48. Published

    Alternative fusion protein strategies to express recalcitrant QconCAT proteins for quantitative proteomics of human drug metabolizing enzymes and transporters

    Russell, M. R., Achour, B., McKenzie, E. A., Lopez, R., Harwood, M. D., Rostami-Hodjegan, A. & Barber, J., 6 Dec 2013, In : Journal of Proteome Research. 12, 12, p. 5934-5942 8 p.

    Research output: Contribution to journalArticle

  49. Published

    Towards a test tube liver for drug metabolism studies

    Achour, B., Nov 2013, University of Manchester. 237 p.

    Research output: ThesisDoctoral Thesis

  50. Published

    The activities of Achromobacter lysyl endopeptidase and Lysobacter lysyl endoproteinase as digestive enzymes for quantitative proteomics.

    Achour, B. & Barber, J., 30 Jul 2013, In : Rapid Communications in Mass Spectrometry. 27, 14, p. 1669-1672 3 p.

    Research output: Contribution to journalArticle

  51. Published

    The activities of Acrombacter lysyl endopeptidase and Lysobacter lysyl endoproteinase as digestive enzymes for quantitative proteomics

    Achour, B. & Barber, J., 30 Jun 2013, In : Rapid Commun Mass Spectrom. 27, 14, p. 1669-1672 4 p.

    Research output: Contribution to journalArticle

  52. 2011
  53. Published
  54. 2010
  55. Published

    Assessing abundance of cytochrome P450 enzymes using mass spectrometry based methods: analysis of porcine liver

    Achour, B., Rostami-Hodjegan, A. & Barber, J., Sep 2010.

    Research output: Contribution to conferencePoster