Dr Brahim Achour

Research Associate

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Publications

  1. 2020
  2. Published

    Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters

    Achour, B., Al-Majdoub, Z., Grybos‐Gajniak, A., Lea, K., Kilford, P., Zhang, M., Knight, D., Barber, J., Schageman, J. & Rostami-Hodjegan, A., 3 Nov 2020, In: Clinical Pharmacology & Therapeutics. 109, 1, p. 222-232 11 p.

    Research output: Contribution to journalArticlepeer-review

  3. E-pub ahead of print

    Label-free Quantitative Proteomics and Substrate Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in ex Vivo Human Skin and a Human Living Skin Equivalent Model

    Couto, N., Newton, J. R. A., Russo, C., Karunakaran, E., Achour, B., Al-Majdoub, Z., Sidaway, J., Rostami-Hodjegan, A., Clench, M. R. & Barber, J., 2 Nov 2020, In: Drug Metabolism and Disposition.

    Research output: Contribution to journalArticlepeer-review

  4. Published

    Mass Spectrometry‐Based Abundance Atlas of ABC Transporters in Human Liver, Gut, Kidney, Brain, and Skin

    Al-Majdoub, Z., Achour, B., Couto, N., Howard, M., Elmorsi, Y., Scotcher, D., Alrubia, S., Elkhateeb, E., Vasilogianni, A. M., Alohali, N., Neuhoff, S., Schmidt, L., Rostami-Hodjegan, A. & Barber, J., 31 Oct 2020, In: FEBS Letters.

    Research output: Contribution to journalArticlepeer-review

  5. Published

    Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics

    Al-Majdoub, Z., Couto, N., Achour, B., Harwood, M. D., Carlson, G., Warhurst, G., Barber, J. & Rostami-Hodjegan, A., 28 Oct 2020, In: Clinical Pharmacology & Therapeutics.

    Research output: Contribution to journalArticlepeer-review

  6. E-pub ahead of print

    Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy

    Darwich, A., Polasek, T. M., Aronson, J. K., Ogungbenro, K., Wright, D. F. B., Achour, B., Reny, J-L., Daali, Y., Eiermann, B., Cook, J., Lesko, L., McLachlan, A. J. & Rostami-Hodjegan, A., 9 Oct 2020, In: Annual Review of Pharmacology and Toxicology. 61

    Research output: Contribution to journalArticlepeer-review

  7. E-pub ahead of print

    Scaling Factors for Clearance in Adult Liver Cirrhosis

    Elkhateeb, E., Achour, B., Scotcher, D., Al-Majdoub, Z., Athwal, V., Barber, J. & Rostami-Hodjegan, A., 25 Sep 2020, In: Drug Metabolism and Disposition.

    Research output: Contribution to journalArticlepeer-review

  8. Published

    Mass Spectrometry of Human Transporters

    Achour, B., Al-Majdoub, Z., Rostami-Hodjegan, A. & Barber, J., 12 Jun 2020, In: Annual Review of Analytical Chemistry. 13, p. 223-247

    Research output: Contribution to journalArticlepeer-review

  9. Published

    Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Inter-correlations in the Human Small Intestine

    Couto, N., Al-Majdoub, Z., Gibson, S. L., Davies, P. J., Achour, B., Harwood, M. D., Carlson, G., Barber, J., Rostami-Hodjegan, A. & Warhurst, G., 20 Jan 2020, In: Drug Metabolism and Disposition. 48, 4, p. 245-254

    Research output: Contribution to journalArticlepeer-review

  10. Published

    Characterization of CYP2B6 K262R Allelic Variants by Quantitative Allele-Specific Proteomics using a QconCAT Standard

    Barber, J., Russell, M. R., Rostami-Hodjegan, A. & Achour, B., 2020, In: Journal of Pharmaceutical and Biomedical Analysis. 178, 112901.

    Research output: Contribution to journalArticlepeer-review

  11. Published

    Proteomic characterisation of drug metabolising enzymes and drug transporters in pig liver

    Elmorsi, Y., Al Feteisi, H., Al-Majdoub, Z., Barber, J., Rostami-Hodjegan, A. & Achour, B., 2020, In: Xenobiotica.

    Research output: Contribution to journalArticlepeer-review

  12. 2019
  13. Published

    Methods and apparatus for quantifying protein abundance in tissues via cell free ribonucleic acids in liquid biopsy

    Rostami-Hodjegan, A., Achour, B. & Rothman, J. E., 3 Oct 2019, IPC No. C12Q 1/68, World Intellectual Property Organization, Patent No. WO 2019/191297 A1, 27 Mar 2018, Priority date 28 Mar 2018

    Research output: Patent

  14. Published
  15. Published

    Proteomic Quantification of Human Blood-Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients

    Al-Majdoub, Z., Al Feteisi, H., Achour, B., Warwood, S., Neuhoff, S., Rostami-Hodjegan, A. & Barber, J., 4 Mar 2019, In: Molecular Pharmaceutics. 16, 3, p. 1220-1233 14 p.

    Research output: Contribution to journalArticlepeer-review

  16. Published

    Quantification of Proteins Involved in Drug Metabolism and Disposition in the Human Liver Using Label-Free Global Proteomics

    Couto, N., Al-Majdoub, Z., Achour, B., Wright, P., Rostami-Hodjegan, A. & Barber, J., 4 Feb 2019, In: Molecular Pharmaceutics. 16, 2, p. 632-647 16 p.

    Research output: Contribution to journalArticlepeer-review

  17. Published
  18. Published
  19. Published

    Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

    Prasad, B., Achour, B., Artursson, P., Hop, C., Lai, Y., Smith, P. C., Barber, J., Wiśniewski, J. R., Spellman, D., Uchida, Y., Zientek, M., Unadkat, J. D. & Rostami-Hodjegan, A., 2019, In: Clinical Pharmacology & Therapeutics. 106, 3, p. 525-543 19 p.

    Research output: Contribution to journalArticlepeer-review

  20. 2018
  21. Published
  22. Published

    Identification and Quantification of Blood-Brain Barrier Transporters in Isolated Rat Brain Microvessels

    Al Feteisi, H., Al-Majdoub, Z., Achour, B., Couto, N., Rostami-Hodjegan, A. & Barber, J., Sep 2018, In: Journal of neurochemistry. 146, 6, p. 670-685

    Research output: Contribution to journalArticlepeer-review

  23. Published
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