Dr Brahim Achour

Research Associate

Affiliations:
ORCID: 0000-0002-2595-5626
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Publications

21 - 30 out of 58Page size: 10
  1. 2018
  2. Published

    Data generated by quantitative LC-MS proteomics are only the start and not the endpoint: Optimization of QconCAT-based measurement of hepatic UDP-glucuronosyltransferase enzymes with reference to catalytic activity

    Achour, B., Dantonio, A. L., Niosi, M., Novak, J. J., Al-Majdoub, Z., Goosen, T. C., Rostami-Hodjegan, A. & Barber, J., 1 Jun 2018, In: Drug Metabolism and Disposition. 46, 6, p. 805-812 8 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1124/dmd.117.079475
  3. Published

    Implications of inter-correlation between hepatic CYP3A4-CYP2C8 enzymes for the evaluation of drug-drug interactions: A case study with repaglinide

    Doki, K., Darwich, A., Achour, B., Tornio, A., Backman, J. T. & Rostami-Hochaghan, A., May 2018, In: British Journal of Clinical Pharmacology. 84, 5, p. 972–986 15 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1111/bcp.13533
  4. 2017
  5. Published

    Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

    Achour, B., Dantonio, A., Niosi, M., Novak, J. J., Fallon, J. K., Barber, J., Smith, P. C., Rostami-Hochaghan, A. & Goosen, T. C., 1 Oct 2017, In: Drug Metabolism and Disposition. 45, 10, p. 1102-1112 11 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1124/dmd.117.076703
  6. Published

    Quantitative Proteomic Analysis of Drug Transporters in Human Blood Brain Barrier

    Al-Majdoub, Z., Al Feteisi, H., Achour, B., Rostami-Hochaghan, A. & Barber, J., 19 Sep 2017.

    Research output: Contribution to conference › Poster

  7. Published

    Quantitative Proteomic Analysis of Drug Transporters in Human Blood Brain Barrier

    Al-Majdoub, Z., Al Feteisi, H., Achour, B., Rostami-Hodjegan, A. & Barber, J., 19 Sep 2017, HUPO2017.

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  8. Published

    Cross-laboratory evaluation of UDP-glucuronosyltransferase (UGT) abundances and correlation with catalytic activity

    Achour, B., Dantonio, A. L., Niosi, M., Novak, J. J., Fallon, J. K., Barber, J., Smith, P. C., Rostami-Hochaghan, A. & Goosen, T. C., 26 Jun 2017.

    Research output: Contribution to conference › Poster

  9. Published

    Variability in protein quantification using different mass spectrometry-based proteomics workflows

    Wegler, C., Gaugaz, F. Z., Andersson, T. B., Oswald, S., Busch, D., Weiss, F., Hammer, H., Poetz, O., Wortelboer, H. M., Steeg, E. V. D., Achour, B., Rostami-Hochaghan, A. & Artursson, P., 26 Jun 2017.

    Research output: Contribution to conference › Poster

  10. Published

    Inter-laboratory variability in mass spectrometry-based proteomics workflows

    Wegler, C., Gaugaz, F. Z., Andersson, T. B., Wiśniewski, J. R., Oswald, S., Gröer, C., Busch, D., Weiss, F., Hammer, H., Joos, T. O., Poetz, O., Wortelboer, H., Steeg, E. V. D., Achour, B., Rostami-Hochaghan, A. & Artursson, P., 21 May 2017.

    Research output: Contribution to conference › Poster

  11. Published

    Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes

    Achour, B., Al Feteisi, H., Lanucara, F., Rostami-Hochaghan, A. & Barber, J., 11 May 2017, In: Drug Metabolism and Disposition. 45, 6, p. 666-675 10 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1124/dmd.116.074732
  12. Published

    Variability in mass spectrometry-based quantification of clinically relevant drug transporters and drug metabolizing enzymes

    Wegler, C., Gaugaz, F. Z., Andersson, T. B., Wiśniewski, J. R., Busch, D., Gröer, C., Oswald, S., Weiss, F., Hammer, H., Joos, T. O., Poetz, O., Achour, B., Rostami-Hochaghan, A., Steeg, E. V. D., Wortelboer, H. M. & Artursson, P., 2017, In: Molecular Pharmaceutics. 14, 9, p. 3142-3151 10 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1021/acs.molpharmaceut.7b00364
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Research Explorer downloads

317
Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes

Research output: Contribution to journal › Article › peer-review

233
In vitro-in vivo extrapolation scaling factors for intestinal P-glycoprotein and breast cancer resistance protein: Part II. The impact of cross-laboratory variations of intestinal transporter relative expression factors on predicted drug disposition

Research output: Contribution to journal › Article › peer-review

165
Application of an LC-MS/MS Method for the Simultaneous Quantification of Human Intestinal Transporter Proteins Absolute Abundance using a QconCAT Technique

Research output: Contribution to journal › Article › peer-review

105
Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

Research output: Contribution to journal › Article › peer-review

96
Identification and Quantification of Blood-Brain Barrier Transporters in Isolated Rat Brain Microvessels

Research output: Contribution to journal › Article › peer-review