Dr Brahim Achour

Research Associate

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Publications

  1. 2020
  2. Published

    Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters

    Achour, B., Al-Majdoub, Z., Grybos‐Gajniak, A., Lea, K., Kilford, P., Zhang, M., Knight, D., Barber, J., Schageman, J. & Rostami-Hodjegan, A., 3 Nov 2020, In: Clinical Pharmacology & Therapeutics. 109, 1, p. 222-232 11 p.

    Research output: Contribution to journalArticlepeer-review

  3. E-pub ahead of print

    Label-free Quantitative Proteomics and Substrate Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in ex Vivo Human Skin and a Human Living Skin Equivalent Model

    Couto, N., Newton, J. R. A., Russo, C., Karunakaran, E., Achour, B., Al-Majdoub, Z., Sidaway, J., Rostami-Hodjegan, A., Clench, M. R. & Barber, J., 2 Nov 2020, In: Drug Metabolism and Disposition.

    Research output: Contribution to journalArticlepeer-review

  4. Published

    Mass Spectrometry‐Based Abundance Atlas of ABC Transporters in Human Liver, Gut, Kidney, Brain, and Skin

    Al-Majdoub, Z., Achour, B., Couto, N., Howard, M., Elmorsi, Y., Scotcher, D., Alrubia, S., Elkhateeb, E., Vasilogianni, A. M., Alohali, N., Neuhoff, S., Schmidt, L., Rostami-Hodjegan, A. & Barber, J., 31 Oct 2020, In: FEBS Letters.

    Research output: Contribution to journalArticlepeer-review

  5. Published

    Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics

    Al-Majdoub, Z., Couto, N., Achour, B., Harwood, M. D., Carlson, G., Warhurst, G., Barber, J. & Rostami-Hodjegan, A., 28 Oct 2020, In: Clinical Pharmacology & Therapeutics.

    Research output: Contribution to journalArticlepeer-review

  6. E-pub ahead of print

    Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy

    Darwich, A., Polasek, T. M., Aronson, J. K., Ogungbenro, K., Wright, D. F. B., Achour, B., Reny, J-L., Daali, Y., Eiermann, B., Cook, J., Lesko, L., McLachlan, A. J. & Rostami-Hodjegan, A., 9 Oct 2020, In: Annual Review of Pharmacology and Toxicology. 61

    Research output: Contribution to journalArticlepeer-review

  7. E-pub ahead of print

    Scaling Factors for Clearance in Adult Liver Cirrhosis

    Elkhateeb, E., Achour, B., Scotcher, D., Al-Majdoub, Z., Athwal, V., Barber, J. & Rostami-Hodjegan, A., 25 Sep 2020, In: Drug Metabolism and Disposition.

    Research output: Contribution to journalArticlepeer-review

  8. Published

    Mass Spectrometry of Human Transporters

    Achour, B., Al-Majdoub, Z., Rostami-Hodjegan, A. & Barber, J., 12 Jun 2020, In: Annual Review of Analytical Chemistry. 13, p. 223-247

    Research output: Contribution to journalArticlepeer-review

  9. Published

    Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Inter-correlations in the Human Small Intestine

    Couto, N., Al-Majdoub, Z., Gibson, S. L., Davies, P. J., Achour, B., Harwood, M. D., Carlson, G., Barber, J., Rostami-Hodjegan, A. & Warhurst, G., 20 Jan 2020, In: Drug Metabolism and Disposition. 48, 4, p. 245-254

    Research output: Contribution to journalArticlepeer-review

  10. Published

    Characterization of CYP2B6 K262R Allelic Variants by Quantitative Allele-Specific Proteomics using a QconCAT Standard

    Barber, J., Russell, M. R., Rostami-Hodjegan, A. & Achour, B., 2020, In: Journal of Pharmaceutical and Biomedical Analysis. 178, 112901.

    Research output: Contribution to journalArticlepeer-review

  11. Published

    Proteomic characterisation of drug metabolising enzymes and drug transporters in pig liver

    Elmorsi, Y., Al Feteisi, H., Al-Majdoub, Z., Barber, J., Rostami-Hodjegan, A. & Achour, B., 2020, In: Xenobiotica.

    Research output: Contribution to journalArticlepeer-review

  12. 2019
  13. Published

    Methods and apparatus for quantifying protein abundance in tissues via cell free ribonucleic acids in liquid biopsy

    Rostami-Hodjegan, A., Achour, B. & Rothman, J. E., 3 Oct 2019, IPC No. C12Q 1/68, World Intellectual Property Organization, Patent No. WO 2019/191297 A1, 27 Mar 2018, Priority date 28 Mar 2018

    Research output: Patent

  14. Published
  15. Published

    Proteomic Quantification of Human Blood-Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients

    Al-Majdoub, Z., Al Feteisi, H., Achour, B., Warwood, S., Neuhoff, S., Rostami-Hodjegan, A. & Barber, J., 4 Mar 2019, In: Molecular Pharmaceutics. 16, 3, p. 1220-1233 14 p.

    Research output: Contribution to journalArticlepeer-review

  16. Published

    Quantification of Proteins Involved in Drug Metabolism and Disposition in the Human Liver Using Label-Free Global Proteomics

    Couto, N., Al-Majdoub, Z., Achour, B., Wright, P., Rostami-Hodjegan, A. & Barber, J., 4 Feb 2019, In: Molecular Pharmaceutics. 16, 2, p. 632-647 16 p.

    Research output: Contribution to journalArticlepeer-review

  17. Published
  18. Published
  19. Published

    Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

    Prasad, B., Achour, B., Artursson, P., Hop, C., Lai, Y., Smith, P. C., Barber, J., Wiśniewski, J. R., Spellman, D., Uchida, Y., Zientek, M., Unadkat, J. D. & Rostami-Hodjegan, A., 2019, In: Clinical Pharmacology & Therapeutics. 106, 3, p. 525-543 19 p.

    Research output: Contribution to journalArticlepeer-review

  20. 2018
  21. Published
  22. Published

    Identification and Quantification of Blood-Brain Barrier Transporters in Isolated Rat Brain Microvessels

    Al Feteisi, H., Al-Majdoub, Z., Achour, B., Couto, N., Rostami-Hodjegan, A. & Barber, J., Sep 2018, In: Journal of neurochemistry. 146, 6, p. 670-685

    Research output: Contribution to journalArticlepeer-review

  23. Published
  24. Published

    Data generated by quantitative LC-MS proteomics are only the start and not the endpoint: Optimization of QconCAT-based measurement of hepatic UDP-glucuronosyltransferase enzymes with reference to catalytic activity

    Achour, B., Dantonio, A. L., Niosi, M., Novak, J. J., Al-Majdoub, Z., Goosen, T. C., Rostami-Hodjegan, A. & Barber, J., 1 Jun 2018, In: Drug Metabolism and Disposition. 46, 6, p. 805-812 8 p.

    Research output: Contribution to journalArticlepeer-review

  25. Published

    Implications of inter-correlation between hepatic CYP3A4-CYP2C8 enzymes for the evaluation of drug-drug interactions: A case study with repaglinide

    Doki, K., Darwich, A., Achour, B., Tornio, A., Backman, J. T. & Rostami-Hochaghan, A., May 2018, In: British Journal of Clinical Pharmacology. 84, 5, p. 972–986 15 p.

    Research output: Contribution to journalArticlepeer-review

  26. 2017
  27. Published

    Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

    Achour, B., Dantonio, A., Niosi, M., Novak, J. J., Fallon, J. K., Barber, J., Smith, P. C., Rostami-Hochaghan, A. & Goosen, T. C., 1 Oct 2017, In: Drug Metabolism and Disposition. 45, 10, p. 1102-1112 11 p.

    Research output: Contribution to journalArticlepeer-review

  28. Published

    Quantitative Proteomic Analysis of Drug Transporters in Human Blood Brain Barrier

    Al-Majdoub, Z., Al Feteisi, H., Achour, B., Rostami-Hochaghan, A. & Barber, J., 19 Sep 2017.

    Research output: Contribution to conferencePoster

  29. Published

    Quantitative Proteomic Analysis of Drug Transporters in Human Blood Brain Barrier

    Al-Majdoub, Z., Al Feteisi, H., Achour, B., Rostami-Hodjegan, A. & Barber, J., 19 Sep 2017, HUPO2017.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  30. Published

    Cross-laboratory evaluation of UDP-glucuronosyltransferase (UGT) abundances and correlation with catalytic activity

    Achour, B., Dantonio, A. L., Niosi, M., Novak, J. J., Fallon, J. K., Barber, J., Smith, P. C., Rostami-Hochaghan, A. & Goosen, T. C., 26 Jun 2017.

    Research output: Contribution to conferencePoster

  31. Published

    Variability in protein quantification using different mass spectrometry-based proteomics workflows

    Wegler, C., Gaugaz, F. Z., Andersson, T. B., Oswald, S., Busch, D., Weiss, F., Hammer, H., Poetz, O., Wortelboer, H. M., Steeg, E. V. D., Achour, B., Rostami-Hochaghan, A. & Artursson, P., 26 Jun 2017.

    Research output: Contribution to conferencePoster

  32. Published

    Inter-laboratory variability in mass spectrometry-based proteomics workflows

    Wegler, C., Gaugaz, F. Z., Andersson, T. B., Wiśniewski, J. R., Oswald, S., Gröer, C., Busch, D., Weiss, F., Hammer, H., Joos, T. O., Poetz, O., Wortelboer, H., Steeg, E. V. D., Achour, B., Rostami-Hochaghan, A. & Artursson, P., 21 May 2017.

    Research output: Contribution to conferencePoster

  33. Published

    Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes

    Achour, B., Al Feteisi, H., Lanucara, F., Rostami-Hochaghan, A. & Barber, J., 11 May 2017, In: Drug Metabolism and Disposition. 45, 6, p. 666-675 10 p.

    Research output: Contribution to journalArticlepeer-review

  34. Published

    Variability in mass spectrometry-based quantification of clinically relevant drug transporters and drug metabolizing enzymes

    Wegler, C., Gaugaz, F. Z., Andersson, T. B., Wiśniewski, J. R., Busch, D., Gröer, C., Oswald, S., Weiss, F., Hammer, H., Joos, T. O., Poetz, O., Achour, B., Rostami-Hochaghan, A., Steeg, E. V. D., Wortelboer, H. M. & Artursson, P., 2017, In: Molecular Pharmaceutics. 14, 9, p. 3142-3151 10 p.

    Research output: Contribution to journalArticlepeer-review

  35. 2016
  36. Published

    Protein quantification of human hepatic drug transporters and metabolizing enzymes: an inter-laboratory and methodological comparison

    Wegler, C., Gaugaz, F. Z., Andersson, T. B., Wiśniewski, J. R., Busch, D., Oswald, S., Weiss, F., Hammer, H., Poetz, O., Joos, T. O., Wortelboer, H. M., Steeg, E. V. D., Achour, B., Rostami-Hochaghan, A. & Artursson, P., 15 Jul 2016, In: Drug Metabolism Reviews. 48, S1, p. 98-98 1 p.

    Research output: Contribution to journalMeeting Abstract

  37. Published

    In vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratroy Comparison of Transporter Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells

    Harwood, M. D., Achour, B., Neuhoff, S., Russell, M. R., Carlson, G., Warhurst, G. & Rostami-Hodjegan, A., 31 Jan 2016, In: Drug Metabolism and Disposition. 44, 3, p. 297-307 11 p.

    Research output: Contribution to journalArticlepeer-review

  38. Published

    Establishing the Relationship between mRNA Expression and Protein Abundance for Seven Transporters in Human Small Intestine: A Pilot Study

    Harwood, M. D., Gibson, S. L., Achour, B., Davies, P. J., Carlson, G. L., Rostami-Hodjegan, A. & Warhurst, G., 28 Jan 2016.

    Research output: Contribution to conferencePoster

  39. Published

    In vitro-in vivo extrapolation scaling factors for intestinal P-glycoprotein and breast cancer resistance protein: Part II. The impact of cross-laboratory variations of intestinal transporter relative expression factors on predicted drug disposition

    Harwood, M. D., Achour, B., Neuhoff, S., Russell, M. R., Carlson, G., Warhurst, G. & Rostami-Hodjegan, A., 2016, In: Drug Metabolism and Disposition. 44, 3, p. 476-480 5 p.

    Research output: Contribution to journalArticlepeer-review

  40. 2015
  41. Published
  42. Published

    Ten years of QconCATs: Application of multiplexed quantification to small medically-relevant proteomes

    Achour, B., Al-Majdoub, Z., Al Feteisi, H., Elmorsi, Y., Rostami-Hochaghan, A. & Barber, J., 30 Nov 2015, In: International Journal of Mass Spectrometry. 391, 2015, p. 93-104 12 p.

    Research output: Contribution to journalArticlepeer-review

  43. Published
  44. Published
  45. Published

    Towards more Realistic Clinical Trial Simulation: Establishing Inter-Correlations between Several Cytochrome P450 Enzyme Abundances in Human Liver

    Wedagedera, J. R., Abduljalil, K., Cain, T., Achour, B., Pathak, S., Dunlavey, M., Jamei, M. & Rostami-Hodjegan, A., 2 Jun 2015.

    Research output: Contribution to conferencePoster

  46. Published

    Meta-analysis of Expression of Hepatic Organic Anion Transporting Polypeptide (OATP) Transporters in Cellular Systems Relative to Human Liver Tissue

    Badée, J., Achour, B., Rostami-Hochaghan, A. & Galetin, A., Apr 2015, In: Drug Metabolism and Disposition. 43, 4, p. 424-432 9 p.

    Research output: Contribution to journalArticlepeer-review

  47. Published
  48. Published

    Application of an LC-MS/MS Method for the Simultaneous Quantification of Human Intestinal Transporter Proteins Absolute Abundance using a QconCAT Technique

    Harwood, M. D., Achour, B., Russell, M. R., Carlson, G. L., Warhurst, G. & Rostami-Hodjegan, A., 28 Feb 2015, In: Journal of Pharmaceutical and Biomedical Analysis. 110, p. 27-33 7 p.

    Research output: Contribution to journalArticlepeer-review

  49. Published

    How LC-MS Proteomics is Revolutionizing PBPK Modelling and Simulation

    Achour, B. & Rostami-Hodjegan, A., 18 Feb 2015.

    Research output: Contribution to conferenceOther

  50. Published
  51. Published

    Label-Free Method for Profiling Human Liver Enzymes: Validation with QconCAT

    Achour, B., Lanucara, F., Feteisi, H. A., Barber, J. & Rostami-Hodjegan, A., 2015.

    Research output: Contribution to conferencePoster

  52. Published

    Laboratory differences in relative expression factors generated for intestinal P-glycoprotein and Breast Cancer Resistance Protein: Relevance to in vitro-in vivo extrapolation

    Harwood, M. D., Achour, B., Neuhoff, S., Carlson, G., Warhurst, G. & Rostami-Hodjegan, A., 2015.

    Research output: Contribution to conferencePoster

  53. Published

    Protein quantification of human hepatic drug transporters and metabolizing enzymes: an inter-laboratory and methodological comparison

    Wegler, C., Gaugaz, F. Z., Andersson, T. B., Wiśniewski, J. R., Oswald, S., Busch, D., Weiss, F., Hammer, H., Joos, T. O., Poetz, O., Wortelboer, H., Steeg, E. V. D., Achour, B., Rostami-Hodjegan, A. & Artursson, P., 2015.

    Research output: Contribution to conferencePoster

  54. 2014
  55. Published

    A Cross-Laboratory Comparison of Caco-2 and Human Intestinal Drug Transporter Protein Abundances

    Harwood, M. D., Achour, B., Courbebaisse, Y., Russell, M. R., Neuhoff, S., Carlson, G., Warhurst, G. & Rostami-Hodjegan, A., Oct 2014.

    Research output: Contribution to conferencePoster

  56. Published
  57. Published
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