Dr Brahim Achour

Research Associate

Affiliations:
ORCID: 0000-0002-2595-5626
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Publications

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  1. Article › Research › Peer-reviewed
  2. Published

    Alternative fusion protein strategies to express recalcitrant QconCAT proteins for quantitative proteomics of human drug metabolizing enzymes and transporters

    Russell, M. R., Achour, B., McKenzie, E. A., Lopez, R., Harwood, M. D., Rostami-Hodjegan, A. & Barber, J., 6 Dec 2013, In : Journal of Proteome Research. 12, 12, p. 5934-5942 8 p.

    Research output: Contribution to journal › Article

    DOI: 10.1021/pr400279u
  3. Published

    Application of an LC-MS/MS Method for the Simultaneous Quantification of Human Intestinal Transporter Proteins Absolute Abundance using a QconCAT Technique

    Harwood, M. D., Achour, B., Russell, M. R., Carlson, G. L., Warhurst, G. & Rostami-Hodjegan, A., 28 Feb 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 110, p. 27-33 7 p.

    Research output: Contribution to journal › Article

    DOI: doi:10.1016/j.jpba.2015.02.043
  4. Published

    Choice of LC-MS methods for the absolute quantification of drug-metabolizing enzymes and transporters in human tissue: A comparative cost analysis

    Al Feteisi, H., Achour, B., Barber, J. & Rostami-Hochaghan, A., Mar 2015, In : The A A P S Journal. 17, 2, p. 438-446 9 p.

    Research output: Contribution to journal › Article

    DOI: 10.1208/s12248-014-9712-6 10.1208/s12248-014-9712-6
  5. Published

    Cytochrome P450 pig liver pie: Determination of individual cytochrome P450 isoform contents in microsomes from two pig livers using liquid chromatography in conjunction with mass spectroscopy

    Achour, B., Barber, J. & Rostami-Hodjegan, A., Nov 2011, In : Drug Metabolism and Disposition. 39, 11, p. 2130-2134 4 p.

    Research output: Contribution to journal › Article

    DOI: 10.1124/dmd.111.040618
  6. Published

    Data generated by quantitative LC-MS proteomics are only the start and not the endpoint: Optimization of QconCAT-based measurement of hepatic UDP-glucuronosyltransferase enzymes with reference to catalytic activity

    Achour, B., Dantonio, A. L., Niosi, M., Novak, J. J., Al-Majdoub, Z., Goosen, T. C., Rostami-Hodjegan, A. & Barber, J., 1 Jun 2018, In : Drug Metabolism and Disposition. 46, 6, p. 805-812 8 p.

    Research output: Contribution to journal › Article

    DOI: 10.1124/dmd.117.079475
  7. Published

    Expression of Hepatic Drug-Metabolizing Cytochrome P450 Enzymes and Their Inter-Correlations: A Meta-Analysis.

    Achour, B., Barber, J. & Rostami-Hodjegan, A., 2014, In : Drug Metabolism and Disposition. 42, 8, p. 1349-1356 7 p.

    Research output: Contribution to journal › Article

    DOI: 10.1124/dmd.114.058834
  8. Published

    GASP and FASP are Complementary for LC-MS/MS Proteomic Analysis of Drug-Metabolizing Enzymes and Transporters in Pig Liver

    Howard, M., Achour, B., Al-Majdoub, Z., Rostami-Hodjegan, A. & Barber, J., 30 Nov 2018, In : Proteomics. 18, 24, 1800200.

    Research output: Contribution to journal › Article

    DOI: 10.1002/pmic.201800200 10.1002/pmic.201800200
  9. Published

    Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes

    Achour, B., Al Feteisi, H., Lanucara, F., Rostami-Hochaghan, A. & Barber, J., 11 May 2017, In : Drug Metabolism and Disposition. 45, 6, p. 666-675 10 p.

    Research output: Contribution to journal › Article

    DOI: 10.1124/dmd.116.074732
  10. Published

    Identification and Quantification of Blood-Brain Barrier Transporters in Isolated Rat Brain Microvessels

    Al Feteisi, H., Al-Majdoub, Z., Achour, B., Couto, N., Rostami-Hodjegan, A. & Barber, J., Sep 2018, In : Journal of neurochemistry. 146, 6, p. 670-685

    Research output: Contribution to journal › Article

    DOI: 10.1111/jnc.14446
  11. Published

    Implications of inter-correlation between hepatic CYP3A4-CYP2C8 enzymes for the evaluation of drug-drug interactions: A case study with repaglinide

    Doki, K., Darwich, A., Achour, B., Tornio, A., Backman, J. T. & Rostami-Hochaghan, A., May 2018, In : British Journal of Clinical Pharmacology. 84, 5, p. 972–986 15 p.

    Research output: Contribution to journal › Article

    DOI: 10.1111/bcp.13533
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Research Explorer downloads

244
Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes

Research output: Contribution to journal › Article

181
In vitro-in vivo extrapolation scaling factors for intestinal P-glycoprotein and breast cancer resistance protein: Part II. The impact of cross-laboratory variations of intestinal transporter relative expression factors on predicted drug disposition

Research output: Contribution to journal › Article

95
Application of an LC-MS/MS Method for the Simultaneous Quantification of Human Intestinal Transporter Proteins Absolute Abundance using a QconCAT Technique

Research output: Contribution to journal › Article

50
Data generated by quantitative LC-MS proteomics are only the start and not the endpoint: Optimization of QconCAT-based measurement of hepatic UDP-glucuronosyltransferase enzymes with reference to catalytic activity

Research output: Contribution to journal › Article

41
Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

Research output: Contribution to journal › Article