Dr Brahim Achour

Research Associate

Affiliations:
ORCID: 0000-0002-2595-5626
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Publications

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  1. Published

    A Cross-Laboratory Comparison of Caco-2 and Human Intestinal Drug Transporter Protein Abundances

    Harwood, M. D., Achour, B., Courbebaisse, Y., Russell, M. R., Neuhoff, S., Carlson, G., Warhurst, G. & Rostami-Hodjegan, A., Oct 2014.

    Research output: Contribution to conference › Poster

  2. Published

    Alternative fusion protein strategies to express recalcitrant QconCAT proteins for quantitative proteomics of human drug metabolizing enzymes and transporters

    Russell, M. R., Achour, B., McKenzie, E. A., Lopez, R., Harwood, M. D., Rostami-Hodjegan, A. & Barber, J., 6 Dec 2013, In : Journal of Proteome Research. 12, 12, p. 5934-5942 8 p.

    Research output: Contribution to journal › Article

    DOI: 10.1021/pr400279u
  3. Published

    Application of an LC-MS/MS Method for the Simultaneous Quantification of Human Intestinal Transporter Proteins Absolute Abundance using a QconCAT Technique

    Harwood, M. D., Achour, B., Russell, M. R., Carlson, G. L., Warhurst, G. & Rostami-Hodjegan, A., 28 Feb 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 110, p. 27-33 7 p.

    Research output: Contribution to journal › Article

    DOI: doi:10.1016/j.jpba.2015.02.043
  4. Published

    Assessing abundance of cytochrome P450 enzymes using mass spectrometry based methods: analysis of porcine liver

    Achour, B., Rostami-Hodjegan, A. & Barber, J., Sep 2010.

    Research output: Contribution to conference › Poster

  5. Published

    Choice of LC-MS methods for the absolute quantification of drug-metabolizing enzymes and transporters in human tissue: A comparative cost analysis

    Al Feteisi, H., Achour, B., Barber, J. & Rostami-Hochaghan, A., Mar 2015, In : The A A P S Journal. 17, 2, p. 438-446 9 p.

    Research output: Contribution to journal › Article

    DOI: 10.1208/s12248-014-9712-6 10.1208/s12248-014-9712-6
  6. Published

    Comparison of label-free and QconCAT quantitative proteomic methods for the quantification of human liver enzymes

    Feteisi, H. A., Lanucara, F., Barber, J., Rostami-Hodjegan, A. & Achour, B., Dec 2015.

    Research output: Contribution to conference › Poster

  7. Published

    Cross-laboratory evaluation of UDP-glucuronosyltransferase (UGT) abundances and correlation with catalytic activity

    Achour, B., Dantonio, A. L., Niosi, M., Novak, J. J., Fallon, J. K., Barber, J., Smith, P. C., Rostami-Hochaghan, A. & Goosen, T. C., 26 Jun 2017.

    Research output: Contribution to conference › Poster

  8. Published

    Cytochrome P450 pig liver pie: Determination of individual cytochrome P450 isoform contents in microsomes from two pig livers using liquid chromatography in conjunction with mass spectroscopy

    Achour, B., Barber, J. & Rostami-Hodjegan, A., Nov 2011, In : Drug Metabolism and Disposition. 39, 11, p. 2130-2134 4 p.

    Research output: Contribution to journal › Article

    DOI: 10.1124/dmd.111.040618
  9. Published

    Data generated by quantitative LC-MS proteomics are only the start and not the endpoint: Optimization of QconCAT-based measurement of hepatic UDP-glucuronosyltransferase enzymes with reference to catalytic activity

    Achour, B., Dantonio, A. L., Niosi, M., Novak, J. J., Al-Majdoub, Z., Goosen, T. C., Rostami-Hodjegan, A. & Barber, J., 1 Jun 2018, In : Drug Metabolism and Disposition. 46, 6, p. 805-812 8 p.

    Research output: Contribution to journal › Article

    DOI: 10.1124/dmd.117.079475
  10. Published

    Establishing the Relationship between mRNA Expression and Protein Abundance for Seven Transporters in Human Small Intestine: A Pilot Study

    Harwood, M. D., Gibson, S. L., Achour, B., Davies, P. J., Carlson, G. L., Rostami-Hodjegan, A. & Warhurst, G., 28 Jan 2016.

    Research output: Contribution to conference › Poster

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Research Explorer downloads

244
Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes

Research output: Contribution to journal › Article

182
In vitro-in vivo extrapolation scaling factors for intestinal P-glycoprotein and breast cancer resistance protein: Part II. The impact of cross-laboratory variations of intestinal transporter relative expression factors on predicted drug disposition

Research output: Contribution to journal › Article

95
Application of an LC-MS/MS Method for the Simultaneous Quantification of Human Intestinal Transporter Proteins Absolute Abundance using a QconCAT Technique

Research output: Contribution to journal › Article

50
Data generated by quantitative LC-MS proteomics are only the start and not the endpoint: Optimization of QconCAT-based measurement of hepatic UDP-glucuronosyltransferase enzymes with reference to catalytic activity

Research output: Contribution to journal › Article

41
Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

Research output: Contribution to journal › Article