Dr Brahim Achour

Research Associate

Affiliations:
ORCID: 0000-0002-2595-5626
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Publications

1 - 10 out of 46Page size: 10
  1. 2010
  2. Published

    Assessing abundance of cytochrome P450 enzymes using mass spectrometry based methods: analysis of porcine liver

    Achour, B., Rostami-Hodjegan, A. & Barber, J., Sep 2010.

    Research output: Contribution to conference › Poster

  3. 2011
  4. Published

    Cytochrome P450 pig liver pie: Determination of individual cytochrome P450 isoform contents in microsomes from two pig livers using liquid chromatography in conjunction with mass spectroscopy

    Achour, B., Barber, J. & Rostami-Hodjegan, A., Nov 2011, In : Drug Metabolism and Disposition. 39, 11, p. 2130-2134 4 p.

    Research output: Contribution to journal › Article

    DOI: 10.1124/dmd.111.040618
  5. 2013
  6. Published

    The activities of Acrombacter lysyl endopeptidase and Lysobacter lysyl endoproteinase as digestive enzymes for quantitative proteomics

    Achour, B. & Barber, J., 30 Jun 2013, In : Rapid Commun Mass Spectrom. 27, 14, p. 1669-1672 4 p.

    Research output: Contribution to journal › Article

  7. Published

    The activities of Achromobacter lysyl endopeptidase and Lysobacter lysyl endoproteinase as digestive enzymes for quantitative proteomics.

    Achour, B. & Barber, J., 30 Jul 2013, In : Rapid Communications in Mass Spectrometry. 27, 14, p. 1669-1672 3 p.

    Research output: Contribution to journal › Article

    DOI: 10.1002/rcm.6612
  8. Published

    Towards a test tube liver for drug metabolism studies

    Achour, B., Nov 2013, University of Manchester. 237 p.

    Research output: Thesis › Doctoral Thesis

  9. Published

    Alternative fusion protein strategies to express recalcitrant QconCAT proteins for quantitative proteomics of human drug metabolizing enzymes and transporters

    Russell, M. R., Achour, B., McKenzie, E. A., Lopez, R., Harwood, M. D., Rostami-Hodjegan, A. & Barber, J., 6 Dec 2013, In : Journal of Proteome Research. 12, 12, p. 5934-5942 8 p.

    Research output: Contribution to journal › Article

    DOI: 10.1021/pr400279u
  10. 2014
  11. Published

    Expression of Hepatic Drug-Metabolizing Cytochrome P450 & Uridine 5ꞌ-Glucuronosyltransferase Enzymes and their Inter-Correlations: Meta-Analysis & Experimental Study

    Achour, B., Barber, J. & Rostami-Hodjegan, A., 2014.

    Research output: Contribution to conference › Poster

  12. Published

    Expression of Hepatic Drug-Metabolizing Cytochrome P450 Enzymes and Their Inter-Correlations: A Meta-Analysis.

    Achour, B., Barber, J. & Rostami-Hodjegan, A., 2014, In : Drug Metabolism and Disposition. 42, 8, p. 1349-1356 7 p.

    Research output: Contribution to journal › Article

    DOI: 10.1124/dmd.114.058834
  13. Published

    Protein expression of various hepatic uridine 5'-diphosphate glucuronosyltransferase (UGT) enzymes and their inter-correlations: A meta-analysis

    Achour, B., Rostami-Hodjegan, A. & Barber, J., 2014, In : Biopharmaceutics and Drug Disposition. 35, p. 353-361 9 p.

    Research output: Contribution to journal › Article

    DOI: 10.1002/bdd.1906
  14. Published

    Simultaneous quantification of the abundance of several cytochrome P450 and uridine 5′-diphospho-glucuronosyltransferase enzymes in human liver microsomes using multiplexed targeted proteomics

    Achour, B., Russell, M. R., Barber, J. & Rostami-Hodjegan, A., 2014, In : Drug Metabolism and Disposition. 42, 4, p. 500-510 10 p.

    Research output: Contribution to journal › Article

    DOI: 10.1124/dmd.113.055632
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Research Explorer downloads

244
Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes

Research output: Contribution to journal › Article

183
In vitro-in vivo extrapolation scaling factors for intestinal P-glycoprotein and breast cancer resistance protein: Part II. The impact of cross-laboratory variations of intestinal transporter relative expression factors on predicted drug disposition

Research output: Contribution to journal › Article

96
Application of an LC-MS/MS Method for the Simultaneous Quantification of Human Intestinal Transporter Proteins Absolute Abundance using a QconCAT Technique

Research output: Contribution to journal › Article

50
Data generated by quantitative LC-MS proteomics are only the start and not the endpoint: Optimization of QconCAT-based measurement of hepatic UDP-glucuronosyltransferase enzymes with reference to catalytic activity

Research output: Contribution to journal › Article

41
Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

Research output: Contribution to journal › Article