Dr Brahim Achour

Research Associate

Affiliations:
ORCID: 0000-0002-2595-5626
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Publications

1 - 10 out of 58Page size: 10
  1. 2020
  2. E-pub ahead of print

    Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters

    Achour, B., Al-Majdoub, Z., Grybos‐Gajniak, A., Lea, K., Kilford, P., Zhang, M., Knight, D., Barber, J., Schageman, J. & Rostami-Hodjegan, A., 3 Nov 2020, In: Clinical Pharmacology & Therapeutics.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1002/cpt.2102
  3. E-pub ahead of print

    Label-free Quantitative Proteomics and Substrate Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in ex Vivo Human Skin and a Human Living Skin Equivalent Model

    Couto, N., Newton, J. R. A., Russo, C., Karunakaran, E., Achour, B., Al-Majdoub, Z., Sidaway, J., Rostami-Hodjegan, A., Clench, M. R. & Barber, J., 2 Nov 2020, In: Drug Metabolism and Disposition.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1124/dmd.120.000168
  4. Published

    Mass Spectrometry‐Based Abundance Atlas of ABC Transporters in Human Liver, Gut, Kidney, Brain, and Skin

    Al-Majdoub, Z., Achour, B., Couto, N., Howard, M., Elmorsi, Y., Scotcher, D., Alrubia, S., Elkhateeb, E., Vasilogianni, A. M., Alohali, N., Neuhoff, S., Schmidt, L., Rostami-Hodjegan, A. & Barber, J., 31 Oct 2020, In: FEBS Letters.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1002/1873-3468.13982
  5. Published

    Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics

    Al-Majdoub, Z., Couto, N., Achour, B., Harwood, M. D., Carlson, G., Warhurst, G., Barber, J. & Rostami-Hodjegan, A., 28 Oct 2020, In: Clinical Pharmacology & Therapeutics.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1002/cpt.2097
  6. E-pub ahead of print

    Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy

    Darwich, A., Polasek, T. M., Aronson, J. K., Ogungbenro, K., Wright, D. F. B., Achour, B., Reny, J-L., Daali, Y., Eiermann, B., Cook, J., Lesko, L., McLachlan, A. J. & Rostami-Hodjegan, A., 9 Oct 2020, In: Annual Review of Pharmacology and Toxicology. 61

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1146/annurev-pharmtox-033020-113257
  7. E-pub ahead of print

    Scaling Factors for Clearance in Adult Liver Cirrhosis

    Elkhateeb, E., Achour, B., Scotcher, D., Al-Majdoub, Z., Athwal, V., Barber, J. & Rostami-Hodjegan, A., 25 Sep 2020, In: Drug Metabolism and Disposition.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1124/dmd.120.000152
  8. Published

    Mass Spectrometry of Human Transporters

    Achour, B., Al-Majdoub, Z., Rostami-Hodjegan, A. & Barber, J., 12 Jun 2020, In: Annual Review of Analytical Chemistry. 13, p. 223-247

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1146/annurev-anchem-091719-024553
  9. Published

    Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Inter-correlations in the Human Small Intestine

    Couto, N., Al-Majdoub, Z., Gibson, S. L., Davies, P. J., Achour, B., Harwood, M. D., Carlson, G., Barber, J., Rostami-Hodjegan, A. & Warhurst, G., 20 Jan 2020, In: Drug Metabolism and Disposition. 48, 4, p. 245-254

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1124/dmd.119.089656
  10. Published

    Characterization of CYP2B6 K262R Allelic Variants by Quantitative Allele-Specific Proteomics using a QconCAT Standard

    Barber, J., Russell, M. R., Rostami-Hodjegan, A. & Achour, B., 2020, In: Journal of Pharmaceutical and Biomedical Analysis. 178, 112901.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.jpba.2019.112901
  11. Published

    Proteomic characterisation of drug metabolising enzymes and drug transporters in pig liver

    Elmorsi, Y., Al Feteisi, H., Al-Majdoub, Z., Barber, J., Rostami-Hodjegan, A. & Achour, B., 2020, In: Xenobiotica.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1080/00498254.2020.1763513
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Research Explorer downloads

315
Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes

Research output: Contribution to journal › Article › peer-review

230
In vitro-in vivo extrapolation scaling factors for intestinal P-glycoprotein and breast cancer resistance protein: Part II. The impact of cross-laboratory variations of intestinal transporter relative expression factors on predicted drug disposition

Research output: Contribution to journal › Article › peer-review

160
Application of an LC-MS/MS Method for the Simultaneous Quantification of Human Intestinal Transporter Proteins Absolute Abundance using a QconCAT Technique

Research output: Contribution to journal › Article › peer-review

103
Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

Research output: Contribution to journal › Article › peer-review

94
Identification and Quantification of Blood-Brain Barrier Transporters in Isolated Rat Brain Microvessels

Research output: Contribution to journal › Article › peer-review