Dr Brahim Achour

Research Associate

Affiliations:
ORCID: 0000-0002-2595-5626
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Publications

1 - 10 out of 47Page size: 10
  1. 2019
  2. Published

    The molecular stethoscope: RNA of drug metabolising enzymes in circulating vesicles correlates with their specific protein content in the liver

    Achour, B., Al-Majdoub, Z., Lea, K., Schageman, J. & Rostami-Hodjegan, A., 16 Sep 2019.

    Research output: Contribution to conference › Poster

  3. E-pub ahead of print

    Quantification of Proteins Involved in Drug Metabolism and Disposition in the Human Liver Using Label-Free Global Proteomics

    Couto, N., Al-Majdoub, Z., Achour, B., Wright, P., Rostami-Hodjegan, A. & Barber, J., 4 Jan 2019, In : Molecular Pharmaceutics.

    Research output: Contribution to journal › Article

    DOI: 10.1021/acs.molpharmaceut.8b00941
  4. Published

    Response to “Determining Allele-Specific Protein Expression (ASPE) Using a Novel Quantitative Concatamer Based Proteomics Method”

    Achour, B., Rostami-Hodjegan, A. & Barber, J., 4 Jan 2019, In : J. Proteome Res.. 18, 1, p. 574-574

    Research output: Contribution to journal › Letter

    DOI: 10.1021/acs.jproteome.8b00871
  5. Published

    Proteomic Quantification of Human Blood-Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients

    Al-Majdoub, Z., Al Feteisi, H., Achour, B., Warwood, S., Neuhoff, S., Rostami-Hodjegan, A. & Barber, J., 2019, In : Molecular Pharmaceutics.

    Research output: Contribution to journal › Article

    DOI: 10.1021/acs.molpharmaceut.8b01189
  6. Published

    Quantitative mass spectrometry-based proteomics in the era of model-informed drug development: Applications in translational pharmacology and recommendations for best practice

    Elkhateeb, E., Vasilogianni, A. M., Alrubia, S., Al-Majdoub, Z., Couto, N., Howard, M., Barber, J., Rostami-Hodjegan, A. & Achour, B., 2019, In : Pharmacology and Therapeutics.

    Research output: Contribution to journal › Article

    DOI: 10.1016/j.pharmthera.2019.107397 10.1016/j.pharmthera.2019.107397
  7. Published

    Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

    Prasad, B., Achour, B., Artursson, P., Hop, C., Lai, Y., Smith, P. C., Barber, J., Wiśniewski, J. R., Spellman, D., Uchida, Y., Zientek, M., Unadkat, J. D. & Rostami-Hodjegan, A., 2019, In : Clinical Pharmacology & Therapeutics. 106, 3, p. 525-543 19 p.

    Research output: Contribution to journal › Article

    DOI: 10.1002/cpt.1537
  8. 2018
  9. Published

    GASP and FASP are Complementary for LC-MS/MS Proteomic Analysis of Drug-Metabolizing Enzymes and Transporters in Pig Liver

    Howard, M., Achour, B., Al-Majdoub, Z., Rostami-Hodjegan, A. & Barber, J., 30 Nov 2018, In : Proteomics. 18, 24, 1800200.

    Research output: Contribution to journal › Article

    DOI: 10.1002/pmic.201800200 10.1002/pmic.201800200
  10. Published

    Identification and Quantification of Blood-Brain Barrier Transporters in Isolated Rat Brain Microvessels

    Al Feteisi, H., Al-Majdoub, Z., Achour, B., Couto, N., Rostami-Hodjegan, A. & Barber, J., Sep 2018, In : Journal of neurochemistry. 146, 6, p. 670-685

    Research output: Contribution to journal › Article

    DOI: 10.1111/jnc.14446
  11. Published

    Implications of inter-correlation between hepatic CYP3A4-CYP2C8 enzymes for the evaluation of drug-drug interactions: A case study with repaglinide and gemfibrozil

    Doki, K., Darwich, A., Achour, B., Tornio, A., Backman, J. T. & Rostami-Hochaghan, A., 1 Jul 2018.

    Research output: Contribution to conference › Poster

  12. Published

    Data generated by quantitative LC-MS proteomics are only the start and not the endpoint: Optimization of QconCAT-based measurement of hepatic UDP-glucuronosyltransferase enzymes with reference to catalytic activity

    Achour, B., Dantonio, A. L., Niosi, M., Novak, J. J., Al-Majdoub, Z., Goosen, T. C., Rostami-Hodjegan, A. & Barber, J., 1 Jun 2018, In : Drug Metabolism and Disposition. 46, 6, p. 805-812 8 p.

    Research output: Contribution to journal › Article

    DOI: 10.1124/dmd.117.079475
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Research Explorer downloads

251
Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes

Research output: Contribution to journal › Article

186
In vitro-in vivo extrapolation scaling factors for intestinal P-glycoprotein and breast cancer resistance protein: Part II. The impact of cross-laboratory variations of intestinal transporter relative expression factors on predicted drug disposition

Research output: Contribution to journal › Article

97
Application of an LC-MS/MS Method for the Simultaneous Quantification of Human Intestinal Transporter Proteins Absolute Abundance using a QconCAT Technique

Research output: Contribution to journal › Article

54
Data generated by quantitative LC-MS proteomics are only the start and not the endpoint: Optimization of QconCAT-based measurement of hepatic UDP-glucuronosyltransferase enzymes with reference to catalytic activity

Research output: Contribution to journal › Article

46
Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

Research output: Contribution to journal › Article