Dr Anthony Tighe BSc, PhD

Inhibitors of the Bub1 spindle assembly checkpoint kinase: synthesis of BAY-320 and comparison with 2OH-BNPP1

Amalina, I., Bennett, A., Whalley, H., Perera, D., McGrail, J. C., Tighe, A., Procter, D. J. & Taylor, S. S., 15 Dec 2021, In: Royal Society Open Science. 8, 12, p. 210854

Research output: Contribution to journal › Article › peer-review

TP53 loss initiates chromosomal instability in fallopian tube epithelial cells

Bronder, D., Tighe, A., Wangsa, D., Zong, D., Meyer, T. J., Wardenaar, R., Minshall, P., Hirsch, D., Heselmeyer-Haddad, K., Nelson, L., Spierings, D., Mcgrail, J., Cam, M., Nussenzweig, A., Foijer, F., Riedel, T. & Taylor, S., 30 Nov 2021, In: DMM Disease Models and Mechanisms.

Research output: Contribution to journal › Article › peer-review

Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models

Coulson-Gilmer, C., Morgan, R. D., Nelson, L., Barnes, B. M., Tighe, A., Wardenaar, R., Spierings, D. C. J., Schlecht, H., Burghel, G. J., Foijer, F., Desai, S., McGrail, J. C. & Taylor, S. S., 16 Oct 2021, In: Journal of Experimental and Clinical Cancer Research. 40, 1, 26 p., 323.

Research output: Contribution to journal › Article › peer-review

Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes

Barnes, B., Nelson, L., Tighe, A., Burghel, G., Lin, I-H., Desai, S., Mcgrail, J., Morgan, R. D. & Taylor, S., 1 Sep 2021, In: Genome Medicine. 13, 1, 19 p., 140.

Research output: Contribution to journal › Article › peer-review

A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity

Nelson, L., Tighe, A., Golder, A., Littler, S., Bakker, B., Moralli, D., Baker, S. M., Donaldson, I., Spierings, D. C. J., Wardenaar, R., Neale, B., Burghel, G., Winter-Roach, B., Edmondson, R., Clamp, A., Jayson, G., Desai, S., Green, C. M., Hayes, A., Foijer, F. & 2 others, Morgan, R. & Taylor, S., 13 Feb 2020, In: Nature Communications. 11, 1, 822.

Research output: Contribution to journal › Article › peer-review

DNA replication vulnerabilities render ovarian cancer cells sensitive to poly(ADP-ribose) glycohydrolase inhibitors

Taylor, S., Pillay, N., Tighe, A., Nelson, L., Littler, S., Coulson-Gilmer, C., Bah, N., Golder, A., James, D., Smith, K., Jordan, A., Morgan, R. D., Ogilvie, D. & Jackson, D., 2019, In: Cancer Cell|Cancer Cell. 35, 3, p. 519-533

Research output: Contribution to journal › Article › peer-review

The p38α stress kinase suppresses aneuploidy tolerance by inhibiting Hif-1α

Taylor, S., Simões-Sousa, S., Littler, S., Thompson, S., Minshall, P., Whalley, H., Bakker, B., Belkot, K., Moralli, D., Bronder, D., Tighe, A., Spierings, D., Bah, N., Graham, J., Nelson, L., Green, C., Foijer, F. & Townsend, P., 16 Oct 2018, In: Cell Reports. 25, 3, p. 749-760.e6

Research output: Contribution to journal › Article › peer-review

Inhibition of Bcl-xL sensitizes cells to mitotic blockers but not mitotic drivers

Bennett, A., Sloss, O., Topham, C., Nelson, L., Tighe, A. & Taylor, S., 8 Oct 2016, In: Open Biology.

Research output: Contribution to journal › Article › peer-review

MYC Is a Major Determinant of Mitotic Cell Fate

Topham, C., Tighe, A., Ly, P., Bennett, A., Sloss, O., Nelson, L., Ridgway, R. A., Huels, D., Littler, S., Schandl, C., Sun, Y., Bechi, B., Procter, D. J., Sansom, O. J., Cleveland, D. W. & Taylor, S. S., 13 Jul 2015, In: Cancer Cell. 28, 1, p. 129-140

Research output: Contribution to journal › Article › peer-review