Dr Anthony Tighe BSc, PhD

Research Fellow

Full contact details
View graph of relations

Publications

  1. 2021
  2. Published

    Inhibitors of the Bub1 spindle assembly checkpoint kinase: synthesis of BAY-320 and comparison with 2OH-BNPP1

    Amalina, I., Bennett, A., Whalley, H., Perera, D., McGrail, J. C., Tighe, A., Procter, D. J. & Taylor, S. S., 15 Dec 2021, In: Royal Society Open Science. 8, 12, p. 210854

    Research output: Contribution to journalArticlepeer-review

  3. Published

    TP53 loss initiates chromosomal instability in fallopian tube epithelial cells

    Bronder, D., Tighe, A., Wangsa, D., Zong, D., Meyer, T. J., Wardenaar, R., Minshall, P., Hirsch, D., Heselmeyer-Haddad, K., Nelson, L., Spierings, D., Mcgrail, J., Cam, M., Nussenzweig, A., Foijer, F., Riedel, T. & Taylor, S., 30 Nov 2021, In: DMM Disease Models and Mechanisms.

    Research output: Contribution to journalArticlepeer-review

  4. Published

    Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models

    Coulson-Gilmer, C., Morgan, R. D., Nelson, L., Barnes, B. M., Tighe, A., Wardenaar, R., Spierings, D. C. J., Schlecht, H., Burghel, G. J., Foijer, F., Desai, S., McGrail, J. C. & Taylor, S. S., 16 Oct 2021, In: Journal of Experimental and Clinical Cancer Research. 40, 1, 26 p., 323.

    Research output: Contribution to journalArticlepeer-review

  5. Published

    Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes

    Barnes, B., Nelson, L., Tighe, A., Burghel, G., Lin, I-H., Desai, S., Mcgrail, J., Morgan, R. D. & Taylor, S., 1 Sep 2021, In: Genome Medicine. 13, 1, 19 p., 140.

    Research output: Contribution to journalArticlepeer-review

  6. 2020
  7. Published

    A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity

    Nelson, L., Tighe, A., Golder, A., Littler, S., Bakker, B., Moralli, D., Baker, S. M., Donaldson, I., Spierings, D. C. J., Wardenaar, R., Neale, B., Burghel, G., Winter-Roach, B., Edmondson, R., Clamp, A., Jayson, G., Desai, S., Green, C. M., Hayes, A., Foijer, F. & 2 others, Morgan, R. & Taylor, S., 13 Feb 2020, In: Nature Communications. 11, 1, 822.

    Research output: Contribution to journalArticlepeer-review

  8. 2019
  9. Published

    DNA replication vulnerabilities render ovarian cancer cells sensitive to poly(ADP-ribose) glycohydrolase inhibitors

    Taylor, S., Pillay, N., Tighe, A., Nelson, L., Littler, S., Coulson-Gilmer, C., Bah, N., Golder, A., James, D., Smith, K., Jordan, A., Morgan, R. D., Ogilvie, D. & Jackson, D., 2019, In: Cancer Cell|Cancer Cell. 35, 3, p. 519-533

    Research output: Contribution to journalArticlepeer-review

  10. 2018
  11. Published

    The p38α stress kinase suppresses aneuploidy tolerance by inhibiting Hif-1α

    Taylor, S., Simões-Sousa, S., Littler, S., Thompson, S., Minshall, P., Whalley, H., Bakker, B., Belkot, K., Moralli, D., Bronder, D., Tighe, A., Spierings, D., Bah, N., Graham, J., Nelson, L., Green, C., Foijer, F. & Townsend, P., 16 Oct 2018, In: Cell Reports. 25, 3, p. 749-760.e6

    Research output: Contribution to journalArticlepeer-review

  12. 2016
  13. Published

    Inhibition of Bcl-xL sensitizes cells to mitotic blockers but not mitotic drivers

    Bennett, A., Sloss, O., Topham, C., Nelson, L., Tighe, A. & Taylor, S., 8 Oct 2016, In: Open Biology.

    Research output: Contribution to journalArticlepeer-review

  14. 2015
  15. Published

    MYC Is a Major Determinant of Mitotic Cell Fate

    Topham, C., Tighe, A., Ly, P., Bennett, A., Sloss, O., Nelson, L., Ridgway, R. A., Huels, D., Littler, S., Schandl, C., Sun, Y., Bechi, B., Procter, D. J., Sansom, O. J., Cleveland, D. W. & Taylor, S. S., 13 Jul 2015, In: Cancer Cell. 28, 1, p. 129-140

    Research output: Contribution to journalArticlepeer-review