Prof Anna Nicolaou BSc PhD CChem FRSC

Professor of Biological Chemistry

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Research interests

My research focuses on Bioactive Lipids and Lipidomics with emphasis on the molecular mechanisms that mediate the role of eicosanoids, endocannabinoids, ceramides and polyunsaturated fatty acids in inflammation, cellular communications and tissue responses. My lab specialises in mass spectrometry-based lipidomics that, when coupled to functional, metabolic, signalling, protein and gene expression and regulation studies, can bring about a greater understanding of the biological role of lipid networks in health and disease. One of my main research questions is to understand the role of eicosanonds and related bioactive lipids in skin inflammation and related disorders. I have used UV-irradiated human skin to follow the formation of lipid mediators during the initiation, maintenance and resolution phase of cutaneous inflammation, and performed nutritional interventions with anti-inflammatory omega-3 polyunsaturated fatty acids to assess the prevalence of novel anti-inflammatory and pro-resolution metabolites. There is also a strong interest in the mechanisms mediating the cross-talk between epidermal and dermal resident cells both in supporting skin homeostasis and in response to inflammation, injury and wound healing. Further to this, and through collaborative studies, I am involved in a range of projects exploring the role of bioactive lipids in the ocular, cardiovascular and reproductive systems, cancer, immunity and neuroinflammation.

 

Methodological knowledge

Lipid biochemistry mass spectrometry-based lipidomics, bioanalytics

Projects

Research and projects