Prof Angeliki Malliri

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Publications

  1. 2019
  2. Accepted/In press

    The interaction between CASK and the tumour suppressor Dlg1 regulates mitotic spindle orientation in mammalian epithelia

    Porter, A., White, G., Mack, N. & Malliri, A., 14 Jun 2019, (Accepted/In press) In : Journal of Cell Science.

    Research output: Contribution to journalArticle

  3. 2018
  4. Published

    Compartmentalisation of RAC1 Signalling

    Boben Payapilly, A. & Malliri, A., Oct 2018, In : Current opinion in cell biology. 54, p. 50-56 6 p.

    Research output: Contribution to journalArticle

  5. Published

    STEF/TIAM2 mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap

    Woroniuk, A., Porter, A., White, G., Newman, D., Diamantopoulou, Z., Waring, T., Rooney, C., Strathdee, D., Marston, D. J., Hahn, K. M., Sansom, O. J., Zech, T. & Malliri, A., 2018, In : Nature Communications.

    Research output: Contribution to journalArticle

  6. 2017
  7. Published

    TIAM1 antagonizes TAZ/YAP both in the destruction complex in the cytoplasm and in the nucleus to inhibit invasion of intestinal epithelial cells

    Diamantopoulou, Z., White, G., Fadlullah Wilmot, M. Z. H., Dreger, M., Pickering, K., Maltas, J., Ashton, G., MacLeod, R., Baillie, G. S., Kouskoff, V., Lacaud, G., Murray, G. I., Sansom, O. J., Hurlstone, A. & Malliri, A., 8 May 2017, In : Cancer Cell. 31, 5, p. 621–634 14 p., e6.

    Research output: Contribution to journalArticle

  8. Published

    HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

    Myant, K. B., Cammareri, P., Hodder, M. C., Wills, J., Von Kriegsheim, A., Győrffy, B., Rashid, M., Polo, S., Maspero, E., Vaughan, L., Gurung, B., Barry, E., Malliri, A., Camargo, F., Adams, D. J., Iavarone, A., Lasorella, A. & Sansom, O. J., Feb 2017, In : EMBO Molecular Medicine . p. 181-197

    Research output: Contribution to journalArticle

  9. 2016
  10. Published

    Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms

    Marei, H. & Malliri, A., 21 Jul 2016, In : Small GTPases.

    Research output: Contribution to journalArticle

  11. Published

    Proteomic Analysis of Rac1 Signalling Regulation by Guanine Nucleotide Exchange Factors

    Marei, H., Carpy, A., Macek, B. & Malliri, A., 6 May 2016, In : Cell Cycle.

    Research output: Contribution to journalArticle

  12. Accepted/In press

    Deregulation of Rho GTPases in cancer

    Porter, A., Papaioannou, A. & Malliri, A., 28 Mar 2016, (Accepted/In press) In : Small GTPases.

    Research output: Contribution to journalArticle

  13. Published

    Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

    Marei, H., Carpy, A., Woroniuk, A., Vennin, C., White, G., Timpson, P., Macek, B. & Malliri, A., 2016, In : Nature Communications.

    Research output: Contribution to journalArticle

  14. Published

    GEFs: Dual regulation of Rac1 signaling

    Hadir Marei1 & Malliri, A., 2016, In : Small GTPases.

    Research output: Contribution to journalArticle

  15. 2015
  16. Published

    HUWE1 ubiquitylates and degrades the Rac activator TIAM1 promoting cell–cell adhesion disassembly, migration and invasion

    Vaughan, L., Tan, C-T., Chapman, A., Nonaka, D., Mack, N., Smith, D., Booton, R., Hurlstone, A. & Malliri, A., 6 Jan 2015, In : Cell Reports. 10, 1

    Research output: Contribution to journalArticle

  17. Published

    Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation

    Whalley, H. J., Porter, A. P., Diamantopoulou, Z., White, G. R. M., Castañeda-Saucedo, E. & Malliri, A., 2015, In : Nature Communications.

    Research output: Contribution to journalArticle

  18. 2013
  19. Published

    Constitutive rac activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression

    Dalton, L. E., Kamarashev, J., Barinaga-Rementeria Ramirez, I., White, G., Malliri, A. & Hurlstone, A., Jun 2013, In : Journal of Investigative Dermatology. 133, 6, p. 1572-1581 9 p.

    Research output: Contribution to journalArticle

  20. Published

    The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation

    Castillo-Lluva, S., Tan, C. T., Daugaard, M., Sorensen, P. H. B. & Malliri, A., 28 Mar 2013, In : Oncogene. 32, 13, p. 1735-1742 7 p.

    Research output: Contribution to journalArticle

  21. Published

    Enhanced detection of ubiquitin isopeptides using reductive methylation

    Chicooree, N., Connolly, Y., Tan, C. T., Malliri, A., Li, Y., Smith, D. L. & Griffiths, J. R., Mar 2013, In : Journal of the American Society for Mass Spectrometry. 24, 3, p. 421-430 9 p.

    Research output: Contribution to journalArticle

  22. Published

    A novel approach to the analysis of SUMOylation with the independent use of trypsin and elastase digestion followed by database searching utilising consecutive residue addition to lysine

    Chicooree, N., Griffiths, J. R., Connolly, Y., Tan, C., Malliri, A., Eyers, C. E. & Smith, D. L., 15 Jan 2013, In : Rapid communications in mass spectrometry : RCM. 27, 1, p. 127-134 7 p.

    Research output: Contribution to journalArticle

  23. Published

    Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes

    Daugaard, M., Nitsch, R., Razaghi, B., McDonald, L., Jarrar, A., Torrino, S., Castillo-Lluva, S., Rotblat, B., Li, L., Malliri, A., Lemichez, E., Mettouchi, A., Berman, J. N., Penninger, J. M. & Sorensen, P. H., 2013, In : Nature Communications. 4, 2180.

    Research output: Contribution to journalArticle

  24. 2012
  25. Published

    β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity

    Mack, N. A., Porter, A. P., Whalley, H. J., Schwarz, J. P., Jones, R. C., Khaja, A. S. S., Bjartell, A., Anderson, K. I. & Malliri, A., Nov 2012, In : Nature Cell Biology. 14, 11, p. 1169-1180 11 p.

    Research output: Contribution to journalArticle

  26. 2011
  27. Published

    The diverse roles of Rac signaling in tumorigenesis

    Mack, N. A., Whalley, H. J., Castillo-Lluva, S. & Malliri, A., 15 May 2011, In : Cell Cycle. 10, 10, p. 1571-1581 10 p.

    Research output: Contribution to journalArticle

  28. Published

    UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer

    Daskalos, A., Oleksiewicz, U., Filia, A., Nikolaidis, G., Xinarianos, G., Gosney, J. R., Malliri, A., Field, J. K. & Liloglou, T., 1 Mar 2011, In : Cancer. 117, 5, p. 1027-1037 10 p.

    Research output: Contribution to journalArticle

  29. 2009
  30. Published

    Src-Induced Disassembly of Adherens Junctions Requires Localized Phosphorylation and Degradation of the Rac Activator Tiam1

    Woodcock, S. A., Rooney, C., Liontos, M., Connolly, Y., Zoumpourlis, V., Whetton, A. D., Gorgoulis, V. G. & Malliri, A., 13 Mar 2009, In : Molecular Cell. 33, 5, p. 639-653 14 p.

    Research output: Contribution to journalArticle

  31. 2006
  32. Published

    The Rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development

    Malliri, A., Rygiel, T. P., Van Der Kammen, R. A., Song, J. Y., Engers, R., Hurlstone, A. F. L., Clevers, H. & Collard, J. G., 6 Jan 2006, In : Journal of Biological Chemistry. 281, 1, p. 543-548 5 p.

    Research output: Contribution to journalArticle

  33. 2004
  34. Published

    The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions

    Malliri, A., Van Es, S., Huveneers, S. & Collard, J. G., 16 Jul 2004, In : Journal of Biological Chemistry. 279, 29, p. 30092-30098 6 p.

    Research output: Contribution to journalArticle

  35. 2002
  36. Published

    Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours

    Malliri, A., Van der Kammen, R. A., Clark, K., Van der Valk, M., Michiels, F. & Collard, J. G., 20 Jun 2002, In : Nature. 417, 6891, p. 867-871 4 p.

    Research output: Contribution to journalArticle

  37. Published

    Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

    Lambert, J. M., Lambert, Q. T., Reuther, G. W., Malliri, A., Siderovski, D. P., Sondek, J., Collard, J. G. & Der, C. J., 2002, In : Nature Cell Biology. 4, 8, p. 621-625 4 p.

    Research output: Contribution to journalArticle

  38. 1998
  39. Published

    The transcription factor AP-1 is required for EGF-induced activation of Rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells

    Malliri, A., Symons, M., Hennigan, R. F., Hurlstone, A. F. L., Lamb, R. F., Wheeler, T. & Ozanne, B. W., 16 Nov 1998, In : Journal of Cell Biology. 143, 4, p. 1087-1099 12 p.

    Research output: Contribution to journalArticle

  40. 1996
  41. Published

    Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia.

    Loughran, O., Malliri, A., Owens, D., Gallimore, P. H., Stanley, M. A., Ozanne, B., Frame, M. C. & Parkinson, E. K., 1 Aug 1996, In : Oncogene. 13, 3

    Research output: Contribution to journalArticle

  42. 1994
  43. Published

    C-jun oncogene expression in nonsmall cell lung-cancer.

    Koutselini, H., Malliri, A., Papadakis, E., Gillespie, D. & Spandidos, D., Mar 1994, In : Oncology Reports. 1, 2

    Research output: Contribution to journalArticle

  44. 1993
  45. Published

    Detection of hepatitis B virus DNA and mutations in K-ras and p53 genes in human hepatocellular carcinomas

    Nikolaidou, A., Liloglou, T., Malliri, A., Ergazaki, M., Tiniakos, G., Tiniakos, D. & Spandidos, D. A., 1993, In : International Journal of Oncology. 3, 4, p. 593-596 3 p.

    Research output: Contribution to journalArticle

  46. Published

    p53 Expression in end stage squamous cell carcinoma of the head and neck prior to chemotherapy treatment: Expression correlates with a very poor clinical outcome

    Field, J. K., Malliri, A., Butt, S. A., Gosney, J. R., Phillips, D., Spandidos, D. A. & Jones, A. S., 1993, In : International Journal of Oncology. 3, 3, p. 431-435 4 p.

    Research output: Contribution to journalArticle

  47. 1992
  48. Published

    Ras and p53 expression in non-small-cell lung-cancer patients - p53 over-expression correlates with a poor prognosis.

    Papadakis, E., Malliri, A., Linardopoulos, S., Karaiossifidi, H., Field, J. & Spandidos, D., Sep 1992, In : International Journal of Oncology. 1, 4

    Research output: Contribution to journalArticle

  49. Published

    Mutations in the p53 gene at codon 249 are rare in squamous-cell carcinoma of the head and neck.

    Field, J., Malliri, A., Jones, A. & Spandidos, D., Aug 1992, In : International Journal of Oncology. 1, 3

    Research output: Contribution to journalArticle

  50. Published

    Expression of ras Rb1 and p53 proteins in human breast cancer

    Spandidos, D. A., Karaiossifidi, H., Malliri, A., Linardopoulos, S., Vassilaros, S., Tsikkinis, A. & Field, J. K., 1992, In : Anticancer Research. 12, 1, p. 81-89 8 p.

    Research output: Contribution to journalArticle

  51. 1991
  52. Published

    Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck

    Field, J. K., Spandidos, D. A., Malliri, A., Gosney, J. R., Yiagnisis, M. & Stell, P. M., 1991, In : British Journal of Cancer. 64, 3, p. 573-577 4 p.

    Research output: Contribution to journalArticle

  53. Published

    Implication of the RAS and MYC oncoproteins in the pathogenesis of Mycosis Fungoides

    Tosca, A., Linardopoulos, S., Malliri, A., Hatziolou, E., Nicolaidou, A. & Spandidos, D. A., 1991, In : Anticancer Research. 11, 4, p. 1433-1438 5 p.

    Research output: Contribution to journalArticle

  54. Published

    p53 expression in cytologic specimens from benign and malignant breast lesions

    Koutselini, H., Malliri, A., Field, J. K. & Spandidos, D. A., 1991, In : Anticancer Research. 11, 4, p. 1415-1419 4 p.

    Research output: Contribution to journalArticle

  55. Published

    Ras p21 expression in brain tumors: Elevated expression in malignant astrocytomas and glioblastomas multiforme

    Arvanitis, D., Malliri, A., Antoniou, D., Linardopoulos, S., Field, J. K. & Spandidos, D. A., 1991, In : In Vivo. 5, 4, p. 317-322 5 p.

    Research output: Contribution to journalArticle

  56. 1990
  57. Published

    Elevated expression of AP-1 activity in human breast tumors as compared to normal adjacent tissue

    Linardopoulos, S., Malliri, A., Pintzas, A., Vassilaros, S., Tsikkinis, A. & Spandidos, D. A., 1990, In : Anticancer Research. 10, 6, p. 1711-1713 2 p.

    Research output: Contribution to journalArticle

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