Dr Angélica Santiago-Gómez

Research Associate

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Publications

  1. 2019
  2. Published

    Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

    Eyre, R., Alferez-Castro, D., Santiago-Gómez, A., Spence, K., Mcconnell, J., Hart, C., M Simoes, B., Lefley, D., Tulotta, C., Storer, J., Gurney, A., Clarke, N., Brown, M., Howell, S., Sims, A. H., Farnie, G., Ottewell, P. D. & Clarke, R. B., 1 Nov 2019, In : Nature Communications. 10, 1, p. 5016 15 p.

    Research output: Contribution to journalArticle

  3. Published

    PAK4 regulates stemness and progression in endocrine resistant ERpositive metastatic breast cancer

    Santiago-Gómez, A., Kedward, T., M Simoes, B., Dragoni, I., NicAmhlaoibh, R., Trivier, E., Sabin, V., Gee, J. M., Sims, A. H., Howell, S. J. & Clarke, R. B., 28 Aug 2019, In : Cancer Letters. 11 p., 10.1016/j.canlet.2019.05.014.

    Research output: Contribution to journalArticle

  4. 2018
  5. Published

    Ethnicity influences breast cancer stem cells' drug resistance

    Kamal, M., Nafie, E. H. O., Elsers, S., Alanwar, S., Ibrahim, R., Farag, F., Mlees, M., Simões, B. M., Spence, K., Santiago-Gómez, A., Salem, M. L. & Clarke, R. B., Jul 2018, In : Breast Journal. 24, 4, p. 701-703 3 p.

    Research output: Contribution to journalArticle

  6. Published

    Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP

    Piggott, L., Silva, A., Robinson, T., Santiago-Gómez, A., Simões, B. M., Becker, M., Fichtner, I., Andera, L., Young, P., Morris, C., Barrett-Lee, P., Alchami, F., Piva, M., Vivanco, M. DM., Clarke, R. B., Gee, J. & Clarkson, R., 15 May 2018, In : Clinical Cancer Research. 24, 10, p. 2452-2463 12 p.

    Research output: Contribution to journalArticle

  7. 2017
  8. Published

    Targeting IL-1 beta-Wnt signalling to prevent breast cancer colonisation in the bone microenvironment

    Eyre, R., Alferez, D., Santiago-Gomez, A., Spence, K., McConnell, J., Simoes, B., Hart, C., Lefley, D., Tulotta, C., Gurney, A., Howell, S., Brown, M., Sims, A., Farnie, G., Ottewell, P. & Clarke, R., Dec 2017, In : Clinical and Experimental Metastasis. 34, 8, p. 493-493

    Research output: Contribution to journalMeeting Abstract

  9. 2016
  10. Published

    Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis

    Eyre, R., Alférez, D. G., Spence, K., Kamal, M., Shaw, F. L., Simões, B. M., Santiago-Gómez, A., Sarmiento-Castro, A., Bramley, M., Absar, M., Saad, Z., Chatterjee, S., Kirwan, C., Gandhi, A., Armstrong, A. C., Wardley, A. M., O'Brien, C. S., Farnie, G., Howell, S. J. & Clarke, R. B., 28 Sep 2016, In : Journal of Mammary Gland Biology and Neoplasia.

    Research output: Contribution to journalArticle

  11. 2015
  12. Published

    Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.

    M Simoes, B., O'Brien, C., Eyre, R., Silva, A., Yu, L., Sarmiento Castro, A., Alferez-Castro, D., Spence, K., Santiago-Gomez, A., Chemi, F., Acar, A., Gandhi, A., Howell, A., Brennan, K., Rydén, L., Catalano, S., Andó, S., Gee, J., Ucar, A., Sims, A. H. & 5 others, Marangoni, E., Farnie, G., Landberg, G., Howell, S. & Clarke, R. B., 29 Sep 2015, In : Cell Reports. 12, 12, p. 1968-1977 9 p.

    Research output: Contribution to journalArticle

  13. 2014
  14. Published

    P-cadherin intracellular signalling is dependent on α6β4 integrin activation inducing stem cell and invasive properties in human breast cancer cells

    Vieira, AF., Ribeiro, AS., Dionísio, MR., Sousa, B., Nobre, R., Albergaria, A., Santiago-Gomez, A., Schmitt, F., Clarke, RB. & Paredes, J., 1 Feb 2014, In : Oncotarget. 5, 3, p. 679-692 13 p.

    Research output: Contribution to journalArticle

  15. 2013
  16. Published

    4F2hc-silencing impairs tumorigenicity of HeLa cells via modulation of galectin-3 and β-catenin signaling, and MMP-2 expression

    Santiago-Gómez, A., Barrasa, J. I., Olmo, N., Lecona, E., Burghardt, H., Palacín, M., Lizarbe, M. A. & Turnay, J., Sep 2013, In : Biochimica et biophysica acta. 1833, 9, p. 2045-56 12 p.

    Research output: Contribution to journalArticle

  17. 2012
  18. Published

    Resistance to butyrate impairs bile acid-induced apoptosis in human colon adenocarcinoma cells via up-regulation of Bcl-2 and inactivation of Bax

    Barrasa, J. I., Santiago-Gómez, A., Olmo, N., Lizarbe, M. A. & Turnay, J., Dec 2012, In : Biochimica et biophysica acta. 1823, 12, p. 2201-9 9 p.

    Research output: Contribution to journalArticle

  19. Published

    Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells

    Barrasa, J. I., Olmo, N., Santiago-Gómez, A., Lecona, E., Anglard, P., Turnay, J. & Lizarbe, M. A., Feb 2012, In : Biochimica et biophysica acta. 1823, 2, p. 570-81 12 p.

    Research output: Contribution to journalArticle

  20. 2011
  21. Published

    Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells

    Ignacio Barrasa, J., Olmo, N., Pérez-Ramos, P., Santiago-Gómez, A., Lecona, E., Turnay, J. & Antonia Lizarbe, M., Oct 2011, In : Apoptosis. 16, 10, p. 1054-67 14 p.

    Research output: Contribution to journalArticle

  22. Published

    Structural characterization and unfolding mechanism of human 4F2hc ectodomain

    Turnay, J., Fort, J., Olmo, N., Santiago-Gómez, A., Palacín, M. & Lizarbe, M. A. A., May 2011, In : Biochimica et biophysica acta. 1814, 5, p. 536-44 9 p.

    Research output: Contribution to journalArticle

  23. 2008
  24. Published

    Kinetic analysis of butyrate transport in human colon adenocarcinoma cells reveals two different carrier-mediated mechanisms

    Lecona, E., Olmo, N., Turnay, J., Santiago-Gómez, A., López de Silanes, I., Gorospe, M. & Lizarbe, M. A., 1 Jan 2008, In : The Biochemical Journal. 409, 1, p. 311-20 10 p.

    Research output: Contribution to journalArticle

  25. 2007
  26. Published

    Acquisition of resistance to butyrate induces resistance to luminal components and other types of stress in human colon adenocarcinoma cells

    Olmo, N., Turnay, J., Lecona, E., García-Díez, M., Llorente, B., Santiago-Gómez, A. & Lizarbe, M. A., Mar 2007, In : Toxicology in vitro : an international journal published in association with BIBRA. 21, 2, p. 254-61 8 p.

    Research output: Contribution to journalArticle

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Research output: Contribution to journalArticle