Prof Andrew Munro BSc, PhD

Professor

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Publications

  1. 2020
  2. E-pub ahead of print

    The catalytic mechanism of aromatic nitration by cytochrome P450 TxtE: Involvement of a ferric-peroxynitrite intermediate

    Louka, S., Barry, S. M., Heyes, D. J., Mubarak, M. Q. E., Ali, H. S., Alkhalaf, L., Munro, A. W., Scrutton, N. S., Challis, G. L. & De Visser, S. P., 19 Aug 2020, In : Journal of the American Chemical Society.

    Research output: Contribution to journalArticle

  3. Published

    Characterization of the structure and interactions of P450 BM3 using hybrid mass spectrometry approaches

    Jeffreys, L. N., Pacholarz, K. J., Johannissen, L. O., Girvan, H. M., Barran, P. E., Voice, M. W. & Munro, A. W., 2020, In : Journal of Biological Chemistry. 295, 22, p. 7595-7607

    Research output: Contribution to journalArticle

  4. Published

    Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5

    Wright, W., Chenge, J., Girvan, H., Yang, L., Chai, S., Huber, A., Wu, J., Oladimeji, P., Munro, A. & Chen, T., 2020, In : Journal of Medicinal Chemistry. 19 p.

    Research output: Contribution to journalArticle

  5. 2019
  6. Published

    Design and synthesis of imidazole and triazole pyrazoles as Mycobacterium tuberculosis CYP121A1 inhibitors

    Kishk, S., Mclean, K., Sood, S., Smith, D., Evans, J., Helal, M., Gomaa, M., Salama, I., Mostafa, S., de Carvalho, L. P., Levy, C., Munro, A. & Simons, C., 2019, In : ChemistryOpen. 8, 7, p. 995-1011 17 p., doi: 10.1002/open.201900227.

    Research output: Contribution to journalArticle

  7. Published

    MhuD from Mycobacterium tuberculosis - probing a dual role in heme storage and degradation

    Matthews, S., Pacholarz, K., France, A., Jowitt, T., Hay, S., Barran, P. & Munro, A., 2019, In : ACS Infectious Diseases. 8, 5(11), p. 1855-1866 12 p., doi: 10.1021/acsinfecdis.9b00181.

    Research output: Contribution to journalArticle

  8. Published

    Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs

    Jeffreys, L., Poddar, H., Golovanova, M., Levy, C., Girvan, H., Mclean, K., Voice, M. W., Leys, D. & Munro, A., 2019, In : Nature Scientific Reports. 9, 1, p. 1-12 12 p., 1577.

    Research output: Contribution to journalArticle

  9. Published

    Structure-Activity Relationships of cyclo(l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct

    Rajput, S., McLean, K. J., Poddar, H., Selvam, I. R., Nagalingam, G., Triccas, J. A., Levy, C. W., Munro, A. W. & Hutton, C. A., 2019, In : Journal of Medicinal Chemistry. 62, 21, p. 9792-9805 14 p., doi: 10.1021/acs.jmedchem.9b01199.

    Research output: Contribution to journalArticle

  10. Published

    Synthesis and Biological Evaluation of Novel cYY Analogues targeting Mycobacterium tuberculosis CYP121A1

    Kishk, S., Mclean, K., Sood, S., Helal, M., Gomaa, M., Salama, I., Mostafa, S., de Carvalho, L. P., Munro, A. & Simons, C., 2019, In : Bioorganic & Medicinal Chemistry. 27, 8, p. 1546-1561 16 p., doi: 10.1016/j.bmc.2019.02.051.

    Research output: Contribution to journalArticle

  11. 2018
  12. Published

    Cytochrome P450 1A1 opens up to new substrates

    Munro, A., 14 Dec 2018, In : Journal of Biological Chemistry. 293, 50, p. 19211-19212 2 p., jbc.H118.006715.

    Research output: Contribution to journalArticle

  13. Published

    Structural and Catalytic Properties of the Peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus

    Girvan, H., Poddar, H., Mclean, K., Nelson, D. R., Hollywood, K., Levy, C., Leys, D. & Munro, A., Nov 2018, In : JOURNAL OF INORGANIC BIOCHEMISTRY. 188

    Research output: Contribution to journalArticle

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