Dr Aleksandra Galetin

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Publications

  1. 2018
  2. Published

    Noninvasive preclinical and clinical imaging of liver transporter function relevant to drug-induced liver injury

    Kenna, J. G., Waterton, J. C., Baudy, A., Galetin, A., Hines, C. D. G., Hockings, P., Patel, M., Scotcher, D., Sourbron, S., Ziemian, S. & Schuetz, G. 21 Mar 2018 Drug-Induced Liver Toxicity. New York, NY: Humana Press, Inc., p. 627-651 25 p. (Methods in Pharmacology and Toxicology; no. 9781493976768)

    Research output: ResearchChapter

  3. Published
  4. Published

    Gaining mechanistic insight into coproporphyrin I as endogenous biomarker for OATP1B-mediated drug-drug interactions using population pharmacokinetic modelling and simultion

    Barnett, S., Ogungbenro, K., Menochet, K., Shen, H., Humphreys, W. G. & Galetin, A. 2018 In : Clinical Pharmacology & Therapeutics. p. 1-26

    Research output: Research - peer-reviewArticle

  5. 2017
  6. Accepted/In press

    Gaining mechanistic insight into coproporphyrin I as endogenous biomarker for OATP1B mediated drug-drug interactions using population pharmacokinetic modelling and simulation

    Barnett, S., Ogungbenro, K., Ménochet, K., Shen, H., Lai, Y., Humphreys, W. G. & Galetin, A. 5 Dec 2017 (Accepted/In press) In : Clinical Pharmacology & Therapeutics.

    Research output: Research - peer-reviewArticle

  7. Published

    Microsomal and cytosolic scaling factors in dog and human kidney cortex and application for in vitro-in vivo extrapolation of renal metabolic clearance

    Scotcher, D., Billington, S., Brown, J., Jones, C. R., Brown, C. D. A., Rostami-Hochaghan, A. & Galetin, A. May 2017 In : Drug Metabolism and Disposition. 45, 5, p. 556-568 13 p.

    Research output: Research - peer-reviewArticle

  8. Published

    Optimisation of intestinal microsomal preparation in the Rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors

    Hatley, O., Jones, C. R., Galetin, A. & Rostami-Hochaghan, A. 18 Apr 2017 In : Biopharmaceutics & Drug Disposition. 38, 3, p. 187-208 22 p.

    Research output: Research - peer-reviewArticle

  9. Published

    Delineating the role of various factors in renal disposition of digoxin through application of physiologically-based kidney model to renal impairment populations

    Scotcher, D., Jones, C., Galetin, A. & Rostami-Hochaghan, A. Mar 2017 In : Journal of Pharmacology and Experimental Therapeutics. 360, 3, p. 484-495 12 p.

    Research output: Research - peer-reviewArticle

  10. Published

    IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

    Darwich, A. , Aarons, L. , Galetin, A. , Rostami-Hochaghan et al, A. , Margolskee, A. , Pepin, X. , Carlert, S. , Hammarberg, M. , Hilgendorf, C. , Johansson, P. , Karlsson, E. , Murphy, D. , Tannergren, C. , Thorn, H. , Yasin, M. , Mazuir, F. , Nicolas, O. , Ramusovic, S. , Xu, C. , Pathak, S. & 43 others Korjamo, T., Laru, J., Malkki, J., Pappinen, S., Tuunainen, J., Dressman, J., Hansmann, S., Kostewicz, E. S., He, H., Heimbach, T., Wu, F., Hoft, C., Pang, Y., Bolger, M., Huehn, E., Heimbach, T., Wu, F., Hoft, C., Pang, Y., Bolger, M. B., Huehn, E., Lukacova, V., Mullin, J. M., Szeto, K. X., Costales, C., Lin, J., McAllister, M., Modi, S., Rotter, C., Varma, M., Wong, M., Mitra, A., Bevernage, J., Biewenga, J., Peer, A. V., Lloyd, R., Shardlow, C., Langguth, P., Mishenzon, I., Nguyen, M. A., Brown, J., Lennerans, H. & Abrahmsson, B. 1 Jan 2017 In : European Journal of Pharmaceutical Sciences. 96, p. 626-642 17 p.

    Research output: Research - peer-reviewArticle

  11. Published

    Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population

    Tsamandouras, N., Guo, Y., Wendling, T., Hall, S., Galetin, A. & Aarons, L. Jan 2017 In : Pharmacogenetics and Genomics. 27, 1, p. 27-38 12 p.

    Research output: Research - peer-reviewArticle

  12. Published

    Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP

    Tan, M. L., Yoshida, K., Zhao, P., Zhang, L., Nolin, T. D., Piquette-Miller, M., Galetin, A. & Huang, S. M. 2017 In : Clinical Pharmacology and Therapeutics.

    Research output: Research - peer-reviewArticle

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