Dr Aleksandra Galetin

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Publications

  1. 2018
  2. Published

    Dabigatran Etexilate and Digoxin: Comparison as Clinical Probe Substrates for Evaluation of P-gp Inhibition

    Chu, X., Galetin, A., Zamek-gliszczynski, M. J., Zhang, L. & Tweedie, D. J., 1 Nov 2018, In : Clinical Pharmacology & Therapeutics. 104, 5, p. 788-792

    Research output: Contribution to journalArticle

  3. Published

    Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium

    Chu, X., Liao, M., Shen, H., Yoshida, K., Zur, A. A., Arya, V., Galetin, A., Giacomini, K. M., Hanna, I., Kusuhara, H., Lai, Y., Rodrigues, D., Sugiyama, Y., Zamek-gliszczynski, M. J. & Zhang, L., Nov 2018, In : Clinical Pharmacology & Therapeutics. 104, 5, p. 836-864

    Research output: Contribution to journalArticle

  4. Published

    Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

    Guo, Y., Chu, X., Parrott, N. J., Brouwer, K. L. R., Hsu, V., Nagar, S., Matsson, P., Sharma, P., Snoeys, J., Sugiyama, Y., Tatosian, D., Unadkat, J. D., Huang, S. & Galetin, A., 22 Oct 2018, In : Clinical Pharmacology & Therapeutics. 104, 5, p. 865-889

    Research output: Contribution to journalArticle

  5. Published

    The International Transporter Consortium: Summarizing Advances in the Role of Transporters in Drug Development

    Giacomini, K. M., Galetin, A. & Huang, S. M., 22 Oct 2018, In : Clinical Pharmacology & Therapeutics. 104, 5, p. 766-771

    Research output: Contribution to journalArticle

  6. Published

    Predicting human clearance of organic anion transporting polypeptide substrates using cynomolgus monkey: In vitro-in vivo scaling of hepatic uptake clearance

    De Bruyn, T., Ufuk, A., Cantrill, C., Kosa, R. E., Bi, Y. A., Niosi, M., Modi, S., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., Galetin, A. & Houston, J. B., Jul 2018, In : Drug Metabolism and Disposition. 46, 7, p. 989-1000 12 p.

    Research output: Contribution to journalArticle

  7. Published

    In vitro–in vivo extrapolation of OATP1B-mediated drug–drug interactions in cynomolgus monkey

    Ufuk, A., Kosa, R. E., Gao, H., Bi, Y. A., Modi, S., Gates, D., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., Houston, J. B. & Galetin, A., 1 Jun 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 688-699 12 p.

    Research output: Contribution to journalArticle

  8. Published

    Noninvasive preclinical and clinical imaging of liver transporter function relevant to drug-induced liver injury

    Kenna, J. G., Waterton, J. C., Baudy, A., Galetin, A., Hines, C. D. G., Hockings, P., Patel, M., Scotcher, D., Sourbron, S., Ziemian, S. & Schuetz, G., 21 Mar 2018, Drug-Induced Liver Toxicity. New York, NY: Humana Press, Inc., p. 627-651 25 p. (Methods in Pharmacology and Toxicology; no. 9781493976768)

    Research output: Chapter in Book/Report/Conference proceedingChapter

  9. Published

    The impact of lysosomal sequestration on desipramine cellular disposition and metabolic drug-drug interactions in rat and human hepatocytes

    Ufuk, A., Matsunaga, N., Hallifax, D. & Galetin, A., Jan 2018, In : Drug Metabolism and Pharmacokinetics.

    Research output: Contribution to journalArticle

  10. Published

    Comprehensive evaluation of the utility of 20 endogenous molecules as biomarkers of OATP1B inhibition compared to rosuvastatin and coproporphyrin I

    Barnett, S., Ogungbenro, K., Menochet, K., Shen, H., Humphreys, G. W. & Galetin, A., 2018, In : Journal of Pharmacology and Experimental Therapeutics. p. jpet.118.253062

    Research output: Contribution to journalArticle

  11. Published

    Gaining mechanistic insight into coproporphyrin I as endogenous biomarker for OATP1B-mediated drug-drug interactions using population pharmacokinetic modelling and simultion

    Barnett, S., Ogungbenro, K., Menochet, K., Shen, H., Humphreys, W. G. & Galetin, A., 2018, In : Clinical Pharmacology & Therapeutics. p. 1-26

    Research output: Contribution to journalArticle

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