Dr Alain Pluen PhD., B.Sc., M.R.S.C.

Senior Lecturer

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ORCID: 0000-0002-5953-8011
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Publications

1 - 10 out of 77Page size: 10
  1. 2021
  2. Published

    Cluster Percolation Causes Shear Thinning Behavior in Concentrated Solutions of Monoclonal Antibodies

    Lanzaro, A., Roche, A., Sibanda, N., Corbett, D., Davis, P., Shah, M., Pathak, J. A., Uddin, S., van der Walle, C. F., Yuan, X-F., Pluen, A. & Curtis, R., 5 Jul 2021, In: Molecular Pharmaceutics. 18, 7, p. 2669-2682 14 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1021/acs.molpharmaceut.1c00198
  3. 2020
  4. E-pub ahead of print

    Micro- and macro-viscosity relations in high concentration antibody solutions

    Shah, M., Corbett, D., Lanzaro, A., Roche, A., Sibanda, N., Davis, P., Uddin, S., van der Walle, C. F., Curtis, R. & Pluen, A., 20 Jun 2020, (E-pub ahead of print) In: European Journal of Pharmaceutics and Biopharmaceutics. 153, p. 211-221 11 p., 10.1016/j.ejpb.2020.06.007.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.ejpb.2020.06.007
  5. Published

    Advancing therapeutic protein discovery and development through comprehensive computational and biophysical characterization

    Gentiluomo, L., Svilenov, H. L., Augustijn, D., El Bialy, I., Greco, M. L., Kulakova, A., Indrakumar, S., Mahapatra, S., Morales, M. M., Pohl, C., Roche, A., Tosstorff, A., Curtis, R., Derrick, J. P., Norgaard, A., Khan, T. A., Peters, G. H. J., Pluen, A., Rinnan, A., Streicher, W. W. & 6 others, van der Walle, C. F., Uddin, S., Winter, G., Roessner, D., Harris, P. & Friess, W., Feb 2020, In: Molecular Pharmaceutics. 17, 2, p. 426-440 15 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1021/acs.molpharmaceut.9b00852 10.1021/acs.molpharmaceut.9b00852
  6. 2019
  7. Published

    Solvation of Pristine Graphene Using Amino Acids: A Molecular Simulation and Experimental Analysis

    Alkathiri, F. A., McCallion, C., Golovanov, A. P., Burthem, J., Pluen, A. & Bryce, R. A., 19 Dec 2019, In: The Journal of Physical Chemistry Part C: Nanomaterials, Interfaces and Hard Matter. 123, 50, p. 30234-30244 10.1021/acs.jpcc.9b06648.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1021/acs.jpcc.9b06648 10.1021/acs.jpcc.9b06648
  8. Published

    Determination of Protein–Protein Interactions in a Mixture of Two Monoclonal Antibodies

    Singh, P., Roche, A., Walle, C. F. V. D., Uddin, S., Du, J., Warwicker, J., Pluen, A. & Curtis, R., 2 Dec 2019, In: Molecular Pharmaceutics. 16, 12, p. 4775-4786 10.1021/acs.jpcc.9b06648.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1021/acs.molpharmaceut.9b00430 10.1021/acs.molpharmaceut.9b00430
  9. Published

    Evaluation of Temporal Aggregation Processes Using Spatial Intensity Distribution Analysis

    Pluen, A., Hamrang, Z., Buzza, K. & Zindy, E., Aug 2019, Methods in molecular biology: Protein self-assembly. mcmanus, J. (ed.). the netherlands: Springer Nature, Vol. 2039. p. 141-155 14 p.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  10. Published

    Dual-action CXCR4-targeting liposomes in leukemia: function blocking and drug delivery

    Mccallion, C., Peters, A., Booth, A., Rees-Unwin, K., Adams, J., Rahi, R., Pluen, A., Hutchinson, C., Webb, S. & Burthem, J., 23 Jul 2019, In: Blood Advances. p. 2069-2081 12 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1182/bloodadvances.2019000098
  11. Published

    Impact of a Heat Shock Protein Impurity on the Immunogenicity of Biotherapeutic Monoclonal Antibodies

    Rane, S., Dearman, R., Kimber, I., Uddin, S., Bishop, S., Shah, M., Podmore, A., Pluen, A. & Derrick, J., Apr 2019, In: Pharmaceutical Research. 36, 4, 51.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1007/s11095-019-2586-7
  12. Published

    Arginine to lysine mutations increase the aggregation stability of a single chain variable fragment through unfolded state interactions

    Austerberry, J., Thistlethwaite, A., Fisher, K., Golovanov, A. P., Pluen, A., Esfandiary, R., van der Walle, C. F., Warwicker, J., Derrick, J. P. & Curtis, R., 2019, In: Biochemistry.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1021/acs.biochem.9b00367
  13. 2018
  14. Published

    Synthesis and biological activity of a CXCR4-targeting bis(cyclam) lipid

    Peters, A., Mccallion, C., Booth, A., Adams, J. A., Rees-Unwin, K., Pluen, A., Burthem, J. & Webb, S., 21 Sep 2018, In: Organic and Biomolecular Chemistry. 16, 35, p. 6479-6490 12 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1039/C8OB01439F
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Research Explorer downloads

399
The effect of charge mutations on the stability and aggregation of a human single chain Fv fragment

Research output: Contribution to journal › Article › peer-review

372
Delivery of therapeutic shRNA and siRNA by Tat fusion peptide targeting bcr-abl fusion gene in Chronic Myeloid Leukemia cells

Research output: Contribution to journal › Article › peer-review

302
Improved Tat-mediated plasmid DNA transfer by fusion to LK15 peptide

Research output: Contribution to journal › Article › peer-review

247
Evaluation of Aggregate and Silicone-oil Counts in Pre-filled Siliconized Syringes: An orthogonal study characterising the entire subvisible size range

Research output: Contribution to journal › Article › peer-review

158
Arginine to lysine mutations increase the aggregation stability of a single chain variable fragment through unfolded state interactions

Research output: Contribution to journal › Article › peer-review