Zinc mediated azide-alkyne ligation to 1,5- and 1,4,5-substituted 1,2,3-triazoles

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Abstract

A mild method for regioselective formation of 1,5-substituted 1,2,3-triazoles is described. The zinc-mediated reaction works at room temperature and is successful across a wide range of azido/alkynyl substrates. Additionally, the triazole 4-position can be further functionalized through the intermediate aryl-zinc to accommodate a diverse three-component coupling strategy. © 2013 American Chemical Society.

Bibliographical metadata

Original languageEnglish
Pages (from-to)4826-4829
Number of pages3
JournalOrganic letters
Volume15
Issue number18
DOIs
StatePublished - 20 Sep 2013