XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer PatientsCitation formats

  • External authors:
  • Petra Seibold
  • Sabine Behrens
  • Peter Schmezer
  • Irmgard Helmbold
  • Gillian Barnett
  • Charlotte Coles
  • John Yarnold
  • Christopher J Talbot
  • Takashi Imai
  • David Azria
  • C Anne Koch
  • Alison M Dunning
  • Neil Burnet
  • Judith M Bliss
  • R Paul Symonds
  • Tim Rattay
  • Tomo Suga
  • Sarah L Kerns
  • Celine Bourgier
  • Katherine A Vallis
  • Marie-Luise Sautter-Bihl
  • Johannes Claßen
  • Juergen Debus
  • Thomas Schnabel
  • Barry S Rosenstein
  • Frederik Wenz
  • Odilia Popanda
  • Jenny Chang-Claude

Standard

XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients. / Seibold, Petra; Behrens, Sabine; Schmezer, Peter; Helmbold, Irmgard; Barnett, Gillian; Coles, Charlotte; Yarnold, John; Talbot, Christopher J; Imai, Takashi; Azria, David; Koch, C Anne; Dunning, Alison M; Burnet, Neil; Bliss, Judith M; Symonds, R Paul; Rattay, Tim; Suga, Tomo; Kerns, Sarah L; Bourgier, Celine; Vallis, Katherine A; Sautter-Bihl, Marie-Luise; Claßen, Johannes; Debus, Juergen; Schnabel, Thomas; Rosenstein, Barry S; Wenz, Frederik; West, Catharine M; Popanda, Odilia; Chang-Claude, Jenny.

In: International Journal of Radiation: Oncology - Biology - Physics, Vol. 92, No. 5, 01.08.2015, p. 1084-1092.

Research output: Contribution to journalArticlepeer-review

Harvard

Seibold, P, Behrens, S, Schmezer, P, Helmbold, I, Barnett, G, Coles, C, Yarnold, J, Talbot, CJ, Imai, T, Azria, D, Koch, CA, Dunning, AM, Burnet, N, Bliss, JM, Symonds, RP, Rattay, T, Suga, T, Kerns, SL, Bourgier, C, Vallis, KA, Sautter-Bihl, M-L, Claßen, J, Debus, J, Schnabel, T, Rosenstein, BS, Wenz, F, West, CM, Popanda, O & Chang-Claude, J 2015, 'XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients', International Journal of Radiation: Oncology - Biology - Physics, vol. 92, no. 5, pp. 1084-1092. https://doi.org/10.1016/j.ijrobp.2015.04.011

APA

Seibold, P., Behrens, S., Schmezer, P., Helmbold, I., Barnett, G., Coles, C., Yarnold, J., Talbot, C. J., Imai, T., Azria, D., Koch, C. A., Dunning, A. M., Burnet, N., Bliss, J. M., Symonds, R. P., Rattay, T., Suga, T., Kerns, S. L., Bourgier, C., ... Chang-Claude, J. (2015). XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients. International Journal of Radiation: Oncology - Biology - Physics, 92(5), 1084-1092. https://doi.org/10.1016/j.ijrobp.2015.04.011

Vancouver

Seibold P, Behrens S, Schmezer P, Helmbold I, Barnett G, Coles C et al. XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients. International Journal of Radiation: Oncology - Biology - Physics. 2015 Aug 1;92(5):1084-1092. https://doi.org/10.1016/j.ijrobp.2015.04.011

Author

Seibold, Petra ; Behrens, Sabine ; Schmezer, Peter ; Helmbold, Irmgard ; Barnett, Gillian ; Coles, Charlotte ; Yarnold, John ; Talbot, Christopher J ; Imai, Takashi ; Azria, David ; Koch, C Anne ; Dunning, Alison M ; Burnet, Neil ; Bliss, Judith M ; Symonds, R Paul ; Rattay, Tim ; Suga, Tomo ; Kerns, Sarah L ; Bourgier, Celine ; Vallis, Katherine A ; Sautter-Bihl, Marie-Luise ; Claßen, Johannes ; Debus, Juergen ; Schnabel, Thomas ; Rosenstein, Barry S ; Wenz, Frederik ; West, Catharine M ; Popanda, Odilia ; Chang-Claude, Jenny. / XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients. In: International Journal of Radiation: Oncology - Biology - Physics. 2015 ; Vol. 92, No. 5. pp. 1084-1092.

Bibtex

@article{45567e1cac1f469e95f3c89046c48797,
title = "XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients",
abstract = "PURPOSE: To identify single-nucleotide polymorphisms (SNPs) in oxidative stress-related genes associated with risk of late toxicities in breast cancer patients receiving radiation therapy.METHODS AND MATERIALS: Using a 2-stage design, 305 SNPs in 59 candidate genes were investigated in the discovery phase in 753 breast cancer patients from 2 prospective cohorts from Germany. The 10 most promising SNPs in 4 genes were evaluated in the replication phase in up to 1883 breast cancer patients from 6 cohorts identified through the Radiogenomics Consortium. Outcomes of interest were late skin toxicity and fibrosis of the breast, as well as an overall toxicity score (Standardized Total Average Toxicity). Multivariable logistic and linear regression models were used to assess associations between SNPs and late toxicity. A meta-analysis approach was used to summarize evidence.RESULTS: The association of a genetic variant in the base excision repair gene XRCC1, rs2682585, with normal tissue late radiation toxicity was replicated in all tested studies. In the combined analysis of discovery and replication cohorts, carrying the rare allele was associated with a significantly lower risk of skin toxicities (multivariate odds ratio 0.77, 95% confidence interval 0.61-0.96, P=.02) and a decrease in Standardized Total Average Toxicity scores (-0.08, 95% confidence interval -0.15 to -0.02, P=.016).CONCLUSIONS: Using a stage design with replication, we identified a variant allele in the base excision repair gene XRCC1 that could be used in combination with additional variants for developing a test to predict late toxicities after radiation therapy in breast cancer patients.",
keywords = "Adult, Aged, Aged, 80 and over, Alleles, Breast, Breast Neoplasms, Cohort Studies, DNA-Binding Proteins, Female, Fibrosis, Genetic Predisposition to Disease, Genome-Wide Association Study, Germany, Humans, Middle Aged, Odds Ratio, Oxidative Stress, Phenotype, Polymorphism, Single Nucleotide, Predictive Value of Tests, Radiation Injuries, Radiation Tolerance, X-ray Repair Cross Complementing Protein 1, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Petra Seibold and Sabine Behrens and Peter Schmezer and Irmgard Helmbold and Gillian Barnett and Charlotte Coles and John Yarnold and Talbot, {Christopher J} and Takashi Imai and David Azria and Koch, {C Anne} and Dunning, {Alison M} and Neil Burnet and Bliss, {Judith M} and Symonds, {R Paul} and Tim Rattay and Tomo Suga and Kerns, {Sarah L} and Celine Bourgier and Vallis, {Katherine A} and Marie-Luise Sautter-Bihl and Johannes Cla{\ss}en and Juergen Debus and Thomas Schnabel and Rosenstein, {Barry S} and Frederik Wenz and West, {Catharine M} and Odilia Popanda and Jenny Chang-Claude",
note = "Copyright {\textcopyright} 2015 Elsevier Inc. All rights reserved.",
year = "2015",
month = aug,
day = "1",
doi = "10.1016/j.ijrobp.2015.04.011",
language = "English",
volume = "92",
pages = "1084--1092",
journal = "International Journal of Radiation: Oncology - Biology - Physics",
issn = "0360-3016",
publisher = "Elsevier BV",
number = "5",

}

RIS

TY - JOUR

T1 - XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients

AU - Seibold, Petra

AU - Behrens, Sabine

AU - Schmezer, Peter

AU - Helmbold, Irmgard

AU - Barnett, Gillian

AU - Coles, Charlotte

AU - Yarnold, John

AU - Talbot, Christopher J

AU - Imai, Takashi

AU - Azria, David

AU - Koch, C Anne

AU - Dunning, Alison M

AU - Burnet, Neil

AU - Bliss, Judith M

AU - Symonds, R Paul

AU - Rattay, Tim

AU - Suga, Tomo

AU - Kerns, Sarah L

AU - Bourgier, Celine

AU - Vallis, Katherine A

AU - Sautter-Bihl, Marie-Luise

AU - Claßen, Johannes

AU - Debus, Juergen

AU - Schnabel, Thomas

AU - Rosenstein, Barry S

AU - Wenz, Frederik

AU - West, Catharine M

AU - Popanda, Odilia

AU - Chang-Claude, Jenny

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - PURPOSE: To identify single-nucleotide polymorphisms (SNPs) in oxidative stress-related genes associated with risk of late toxicities in breast cancer patients receiving radiation therapy.METHODS AND MATERIALS: Using a 2-stage design, 305 SNPs in 59 candidate genes were investigated in the discovery phase in 753 breast cancer patients from 2 prospective cohorts from Germany. The 10 most promising SNPs in 4 genes were evaluated in the replication phase in up to 1883 breast cancer patients from 6 cohorts identified through the Radiogenomics Consortium. Outcomes of interest were late skin toxicity and fibrosis of the breast, as well as an overall toxicity score (Standardized Total Average Toxicity). Multivariable logistic and linear regression models were used to assess associations between SNPs and late toxicity. A meta-analysis approach was used to summarize evidence.RESULTS: The association of a genetic variant in the base excision repair gene XRCC1, rs2682585, with normal tissue late radiation toxicity was replicated in all tested studies. In the combined analysis of discovery and replication cohorts, carrying the rare allele was associated with a significantly lower risk of skin toxicities (multivariate odds ratio 0.77, 95% confidence interval 0.61-0.96, P=.02) and a decrease in Standardized Total Average Toxicity scores (-0.08, 95% confidence interval -0.15 to -0.02, P=.016).CONCLUSIONS: Using a stage design with replication, we identified a variant allele in the base excision repair gene XRCC1 that could be used in combination with additional variants for developing a test to predict late toxicities after radiation therapy in breast cancer patients.

AB - PURPOSE: To identify single-nucleotide polymorphisms (SNPs) in oxidative stress-related genes associated with risk of late toxicities in breast cancer patients receiving radiation therapy.METHODS AND MATERIALS: Using a 2-stage design, 305 SNPs in 59 candidate genes were investigated in the discovery phase in 753 breast cancer patients from 2 prospective cohorts from Germany. The 10 most promising SNPs in 4 genes were evaluated in the replication phase in up to 1883 breast cancer patients from 6 cohorts identified through the Radiogenomics Consortium. Outcomes of interest were late skin toxicity and fibrosis of the breast, as well as an overall toxicity score (Standardized Total Average Toxicity). Multivariable logistic and linear regression models were used to assess associations between SNPs and late toxicity. A meta-analysis approach was used to summarize evidence.RESULTS: The association of a genetic variant in the base excision repair gene XRCC1, rs2682585, with normal tissue late radiation toxicity was replicated in all tested studies. In the combined analysis of discovery and replication cohorts, carrying the rare allele was associated with a significantly lower risk of skin toxicities (multivariate odds ratio 0.77, 95% confidence interval 0.61-0.96, P=.02) and a decrease in Standardized Total Average Toxicity scores (-0.08, 95% confidence interval -0.15 to -0.02, P=.016).CONCLUSIONS: Using a stage design with replication, we identified a variant allele in the base excision repair gene XRCC1 that could be used in combination with additional variants for developing a test to predict late toxicities after radiation therapy in breast cancer patients.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Alleles

KW - Breast

KW - Breast Neoplasms

KW - Cohort Studies

KW - DNA-Binding Proteins

KW - Female

KW - Fibrosis

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Germany

KW - Humans

KW - Middle Aged

KW - Odds Ratio

KW - Oxidative Stress

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Predictive Value of Tests

KW - Radiation Injuries

KW - Radiation Tolerance

KW - X-ray Repair Cross Complementing Protein 1

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.ijrobp.2015.04.011

DO - 10.1016/j.ijrobp.2015.04.011

M3 - Article

C2 - 26072091

VL - 92

SP - 1084

EP - 1092

JO - International Journal of Radiation: Oncology - Biology - Physics

JF - International Journal of Radiation: Oncology - Biology - Physics

SN - 0360-3016

IS - 5

ER -