Visible-Light-Mediated Generation of Nitrile Oxides for the Photoredox Synthesis of Isoxazolines and Isoxazoles

Research output: Contribution to journalArticle

  • Authors:
  • Thomas Svejstrup
  • Wojciech Zawodny
  • James J. Douglas
  • Damon Bidgelli
  • Nadeem S Sheikh
  • And 1 others
  • External authors:
  • Daniele Leonori

Abstract

Visible-light photoredox catalysis enables the synthesis of
biologically relevant isoxazolines and isoxazoles from
hydroxyimino acids. The process shows broad functional group
compatibility and mechanisitic and computational studies support
a visible-light-mediated generation of nitrile oxides by two
sequential oxidative single electron transfer processes.

Bibliographical metadata

Original languageEnglish
JournalChemical Communications- Royal Society of Chemistry
Early online date21 Sep 2016
DOIs
StatePublished - 2016