Variability and regulation of O6-alkylguanine-DNA alkyltransferaseCitation formats

  • Authors:
  • Geoffrey P. Margison
  • Andrew C. Povey
  • Bernd Kaina
  • Mauro F. Santibáñez Koref

Standard

Variability and regulation of O6-alkylguanine-DNA alkyltransferase. / Margison, Geoffrey P.; Povey, Andrew C.; Kaina, Bernd; Santibáñez Koref, Mauro F.

In: Carcinogenesis, Vol. 24, No. 4, 01.04.2003, p. 625-635.

Research output: Contribution to journalArticle

Harvard

Margison, GP, Povey, AC, Kaina, B & Santibáñez Koref, MF 2003, 'Variability and regulation of O6-alkylguanine-DNA alkyltransferase', Carcinogenesis, vol. 24, no. 4, pp. 625-635. https://doi.org/10.1093/carcin/bgg005

APA

Margison, G. P., Povey, A. C., Kaina, B., & Santibáñez Koref, M. F. (2003). Variability and regulation of O6-alkylguanine-DNA alkyltransferase. Carcinogenesis, 24(4), 625-635. https://doi.org/10.1093/carcin/bgg005

Vancouver

Margison GP, Povey AC, Kaina B, Santibáñez Koref MF. Variability and regulation of O6-alkylguanine-DNA alkyltransferase. Carcinogenesis. 2003 Apr 1;24(4):625-635. https://doi.org/10.1093/carcin/bgg005

Author

Margison, Geoffrey P. ; Povey, Andrew C. ; Kaina, Bernd ; Santibáñez Koref, Mauro F. / Variability and regulation of O6-alkylguanine-DNA alkyltransferase. In: Carcinogenesis. 2003 ; Vol. 24, No. 4. pp. 625-635.

Bibtex

@article{873a69e4310d44bdb9ed2f32e82c72ec,
title = "Variability and regulation of O6-alkylguanine-DNA alkyltransferase",
abstract = "O6-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.",
keywords = "Alkylating Agents, Alkylation, Amino Acid Sequence, chemistry, Chromatin, Dna, Human, metabolism, Molecular Sequence Data, O(6)-Methylguanine-DNA Methyltransferase, Phosphorylation, physiology, Promoter Regions (Genetics), Research, Role, Sequence Homology,Amino Acid, Support,Non-U.S.Gov't, Transcription Factors, chemistry: Chromatin, metabolism: DNA, Humans, chemistry: O(6)-Methylguanine-DNA Methyltransferase, Research Support, Non-U.S. Gov't, Sequence Homology, Amino Acid, metabolism: Transcription Factors",
author = "Margison, {Geoffrey P.} and Povey, {Andrew C.} and Bernd Kaina and {Santib{\'a}{\~n}ez Koref}, {Mauro F.}",
note = "UI - 22612553DA - 20030502IS - 0143-3334LA - engPT - Journal ArticlePT - ReviewPT - Review, AcademicRN - 0 (Chromatin)RN - 0 (Transcription Factors)RN - 9007-49-2 (DNA)RN - EC 2.1.1.63 (O(6)-Methylguanine-DNA Methyltransferase)SB - IM",
year = "2003",
month = apr
day = "1",
doi = "10.1093/carcin/bgg005",
language = "English",
volume = "24",
pages = "625--635",
journal = "Carcinogenesis",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Variability and regulation of O6-alkylguanine-DNA alkyltransferase

AU - Margison, Geoffrey P.

AU - Povey, Andrew C.

AU - Kaina, Bernd

AU - Santibáñez Koref, Mauro F.

N1 - UI - 22612553DA - 20030502IS - 0143-3334LA - engPT - Journal ArticlePT - ReviewPT - Review, AcademicRN - 0 (Chromatin)RN - 0 (Transcription Factors)RN - 9007-49-2 (DNA)RN - EC 2.1.1.63 (O(6)-Methylguanine-DNA Methyltransferase)SB - IM

PY - 2003/4/1

Y1 - 2003/4/1

N2 - O6-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.

AB - O6-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.

KW - Alkylating Agents

KW - Alkylation

KW - Amino Acid Sequence

KW - chemistry

KW - Chromatin

KW - Dna

KW - Human

KW - metabolism

KW - Molecular Sequence Data

KW - O(6)-Methylguanine-DNA Methyltransferase

KW - Phosphorylation

KW - physiology

KW - Promoter Regions (Genetics)

KW - Research

KW - Role

KW - Sequence Homology,Amino Acid

KW - Support,Non-U.S.Gov't

KW - Transcription Factors

KW - chemistry: Chromatin

KW - metabolism: DNA

KW - Humans

KW - chemistry: O(6)-Methylguanine-DNA Methyltransferase

KW - Research Support, Non-U.S. Gov't

KW - Sequence Homology, Amino Acid

KW - metabolism: Transcription Factors

U2 - 10.1093/carcin/bgg005

DO - 10.1093/carcin/bgg005

M3 - Article

VL - 24

SP - 625

EP - 635

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 4

ER -