Validity of a 2-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritisCitation formats

Standard

Validity of a 2-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis. / Hensor, Elizabeth M A; McKeigue, Paul ; Ling, Stephanie; Colombo, Marco; Barrett, Jennifer H; Nam, Jackie L.; Freeston, Jane; Buch, Maya; Spiliopoulou, Athina; Agakov, Felix; Kelly, Stephen; Verstappen, Suzanne; MacGregor, Alexander J; Viatte, Sebastien; Barton, Anne; Pitzalis, Costantino; Emery, Paul; MATURA Consortium; IACON Consortium; PEAC Consortium; Conaghan, Philip G; Morgan, Ann W.

In: Rheumatology, 2019.

Research output: Contribution to journalArticlepeer-review

Harvard

Hensor, EMA, McKeigue, P, Ling, S, Colombo, M, Barrett, JH, Nam, JL, Freeston, J, Buch, M, Spiliopoulou, A, Agakov, F, Kelly, S, Verstappen, S, MacGregor, AJ, Viatte, S, Barton, A, Pitzalis, C, Emery, P, MATURA Consortium, IACON Consortium, PEAC Consortium, Conaghan, PG & Morgan, AW 2019, 'Validity of a 2-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis', Rheumatology. https://doi.org/10.1093/rheumatology/kez049

APA

Hensor, E. M. A., McKeigue, P., Ling, S., Colombo, M., Barrett, J. H., Nam, J. L., Freeston, J., Buch, M., Spiliopoulou, A., Agakov, F., Kelly, S., Verstappen, S., MacGregor, A. J., Viatte, S., Barton, A., Pitzalis, C., Emery, P., MATURA Consortium, IACON Consortium, ... Morgan, A. W. (2019). Validity of a 2-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis. Rheumatology. https://doi.org/10.1093/rheumatology/kez049

Vancouver

Author

Hensor, Elizabeth M A ; McKeigue, Paul ; Ling, Stephanie ; Colombo, Marco ; Barrett, Jennifer H ; Nam, Jackie L. ; Freeston, Jane ; Buch, Maya ; Spiliopoulou, Athina ; Agakov, Felix ; Kelly, Stephen ; Verstappen, Suzanne ; MacGregor, Alexander J ; Viatte, Sebastien ; Barton, Anne ; Pitzalis, Costantino ; Emery, Paul ; MATURA Consortium ; IACON Consortium ; PEAC Consortium ; Conaghan, Philip G ; Morgan, Ann W. / Validity of a 2-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis. In: Rheumatology. 2019.

Bibtex

@article{29228810492a4bf7a8c3aa829c1ee673,
title = "Validity of a 2-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis",
abstract = "Objectives: Imaging of joint inflammation provides a standard against which to derive an updated disease activity score (DAS) for rheumatoid arthritis (RA). Our objectives were to develop and validate a DAS based on reweighting the DAS28 components to maximize association with ultrasound-assessed synovitis.Methods: Early RA patients from two observational cohorts (n=434 & n=117), and a clinical trial (n=59) were assessed at intervals up to 104 weeks from baseline; all ultrasound scans were within 1 week of clinical exam. There were 899, 163 and 183 visits in each cohort. Associations of combined ultrasound grey scale and power Doppler scores (GSPD) with TJC28 & SJC28, CRP, ESR, general health visual analogue scale were examined in linear mixed model regressions. Cross-validation evaluated model predictive ability; coefficients learned from training data defined a re-weighted DAS28 which was validated against radiographic progression in independent data (3037 observations; 717 patients).Results: Of the conventional DAS28 components only SJC28 and CRP were associated with GSPD in all three development cohorts. A 2-component model including SJC28 and CRP outperformed a 4-component model (R-squared 0.235, 0.392, 0.380 vs. 0.232, 0.380, 0.375 respectively). The re-weighted 2-component DAS28CRP outperformed conventional DAS28 definitions in predicting GSPD (Δtest log-likelihood<-2.6, p<0.01), Larsen score and presence of erosions. Conclusion: A score based on SJC28 and CRP alone demonstrated stronger associations with synovitis and radiographic progression than the original DAS28 and should be considered in research on pathophysiological manifestations of early RA. Implications for clinical management of RA remain to be established. ",
keywords = "Rheumatoid arthritis, DAS28, ultrasonography, synovitis",
author = "Hensor, {Elizabeth M A} and Paul McKeigue and Stephanie Ling and Marco Colombo and Barrett, {Jennifer H} and Nam, {Jackie L.} and Jane Freeston and Maya Buch and Athina Spiliopoulou and Felix Agakov and Stephen Kelly and Suzanne Verstappen and MacGregor, {Alexander J} and Sebastien Viatte and Anne Barton and Costantino Pitzalis and Paul Emery and {MATURA Consortium} and {IACON Consortium} and {PEAC Consortium} and Conaghan, {Philip G} and Morgan, {Ann W}",
year = "2019",
doi = "10.1093/rheumatology/kez049",
language = "English",
journal = "Rheumatology (Print)",
issn = "1462-0324",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Validity of a 2-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis

AU - Hensor, Elizabeth M A

AU - McKeigue, Paul

AU - Ling, Stephanie

AU - Colombo, Marco

AU - Barrett, Jennifer H

AU - Nam, Jackie L.

AU - Freeston, Jane

AU - Buch, Maya

AU - Spiliopoulou, Athina

AU - Agakov, Felix

AU - Kelly, Stephen

AU - Verstappen, Suzanne

AU - MacGregor, Alexander J

AU - Viatte, Sebastien

AU - Barton, Anne

AU - Pitzalis, Costantino

AU - Emery, Paul

AU - MATURA Consortium

AU - IACON Consortium

AU - PEAC Consortium

AU - Conaghan, Philip G

AU - Morgan, Ann W

PY - 2019

Y1 - 2019

N2 - Objectives: Imaging of joint inflammation provides a standard against which to derive an updated disease activity score (DAS) for rheumatoid arthritis (RA). Our objectives were to develop and validate a DAS based on reweighting the DAS28 components to maximize association with ultrasound-assessed synovitis.Methods: Early RA patients from two observational cohorts (n=434 & n=117), and a clinical trial (n=59) were assessed at intervals up to 104 weeks from baseline; all ultrasound scans were within 1 week of clinical exam. There were 899, 163 and 183 visits in each cohort. Associations of combined ultrasound grey scale and power Doppler scores (GSPD) with TJC28 & SJC28, CRP, ESR, general health visual analogue scale were examined in linear mixed model regressions. Cross-validation evaluated model predictive ability; coefficients learned from training data defined a re-weighted DAS28 which was validated against radiographic progression in independent data (3037 observations; 717 patients).Results: Of the conventional DAS28 components only SJC28 and CRP were associated with GSPD in all three development cohorts. A 2-component model including SJC28 and CRP outperformed a 4-component model (R-squared 0.235, 0.392, 0.380 vs. 0.232, 0.380, 0.375 respectively). The re-weighted 2-component DAS28CRP outperformed conventional DAS28 definitions in predicting GSPD (Δtest log-likelihood<-2.6, p<0.01), Larsen score and presence of erosions. Conclusion: A score based on SJC28 and CRP alone demonstrated stronger associations with synovitis and radiographic progression than the original DAS28 and should be considered in research on pathophysiological manifestations of early RA. Implications for clinical management of RA remain to be established.

AB - Objectives: Imaging of joint inflammation provides a standard against which to derive an updated disease activity score (DAS) for rheumatoid arthritis (RA). Our objectives were to develop and validate a DAS based on reweighting the DAS28 components to maximize association with ultrasound-assessed synovitis.Methods: Early RA patients from two observational cohorts (n=434 & n=117), and a clinical trial (n=59) were assessed at intervals up to 104 weeks from baseline; all ultrasound scans were within 1 week of clinical exam. There were 899, 163 and 183 visits in each cohort. Associations of combined ultrasound grey scale and power Doppler scores (GSPD) with TJC28 & SJC28, CRP, ESR, general health visual analogue scale were examined in linear mixed model regressions. Cross-validation evaluated model predictive ability; coefficients learned from training data defined a re-weighted DAS28 which was validated against radiographic progression in independent data (3037 observations; 717 patients).Results: Of the conventional DAS28 components only SJC28 and CRP were associated with GSPD in all three development cohorts. A 2-component model including SJC28 and CRP outperformed a 4-component model (R-squared 0.235, 0.392, 0.380 vs. 0.232, 0.380, 0.375 respectively). The re-weighted 2-component DAS28CRP outperformed conventional DAS28 definitions in predicting GSPD (Δtest log-likelihood<-2.6, p<0.01), Larsen score and presence of erosions. Conclusion: A score based on SJC28 and CRP alone demonstrated stronger associations with synovitis and radiographic progression than the original DAS28 and should be considered in research on pathophysiological manifestations of early RA. Implications for clinical management of RA remain to be established.

KW - Rheumatoid arthritis

KW - DAS28

KW - ultrasonography

KW - synovitis

U2 - 10.1093/rheumatology/kez049

DO - 10.1093/rheumatology/kez049

M3 - Article

JO - Rheumatology (Print)

JF - Rheumatology (Print)

SN - 1462-0324

ER -