Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles

Research output: Contribution to journalArticle

  • External authors:
  • Nicoló Scalacci
  • Gary W. Black
  • Giulio Mattedi
  • Nicola L. Brown
  • Daniele Castagnolo

Abstract

A chemoenzymatic cascade process for the sustainable production of pyrroles has been developed. Pyrroles were synthesized by exploiting the previously unexplored aromatizing activity of monoamine oxidase enzymes (MAO-N and 6-HDNO). MAO-N/6-HDNO whole cell biocatalysts are able to convert 3-pyrrolines into pyrroles under mild conditions and in high yields. Moreover, MAO-N can work in combination with the ruthenium Grubbs catalyst, leading to the synthesis of pyrroles from diallylamines/-anilines in a one-pot cascade metathesis-aromatization sequence.

Bibliographical metadata

Original languageEnglish
Pages (from-to)1295-1300
Number of pages6
JournalACS Catalysis
Volume7
Issue number2
Early online date27 Dec 2016
DOIs
Publication statusPublished - 3 Feb 2017